Hydralazine Dilates Large Epicardial Coronary Arteries in Conscious Dogs Through an Endothelium-Independent Mechanism
SUMMARYIn chronically instrumented conscious dogs, hydralazine (30–300 μg/kg) and nitroglycerin (NTG 0.03–10 μg/kg) dose-dependently dilated large epicardial coronary arteries. Simultaneously, hydralazine also dose-dependently dilated small coronary arteries, whereas a similar effect was observed on...
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Veröffentlicht in: | Journal of cardiovascular pharmacology 1994-02, Vol.23 (2), p.315-318 |
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creator | la Rochelle, C Drieu Dubois-Randé, J L Hittinger, L Richard, V Berdeaux, A Giudicelli, J F |
description | SUMMARYIn chronically instrumented conscious dogs, hydralazine (30–300 μg/kg) and nitroglycerin (NTG 0.03–10 μg/kg) dose-dependently dilated large epicardial coronary arteries. Simultaneously, hydralazine also dose-dependently dilated small coronary arteries, whereas a similar effect was observed only after NTG ≥0.3 μg/kg. When large coronary arteries were deendothelialized by a balloon angioplasty catheter, dilation of large coronary arteries in response to acetylcholine (ACh 0.3 μg/kg) and to reactive hyperemia was reduced by 87 and 95%, respectively. In contrast, vasodilation of large coronary arteries induced by hydralazine and NTG was only minimally and similarly affected (-19% for both drugs). These findings demonstrate that in vivo hydralazine-induced dilation of large coronary arteries is endothelium independent. |
doi_str_mv | 10.1097/00005344-199402000-00020 |
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Simultaneously, hydralazine also dose-dependently dilated small coronary arteries, whereas a similar effect was observed only after NTG ≥0.3 μg/kg. When large coronary arteries were deendothelialized by a balloon angioplasty catheter, dilation of large coronary arteries in response to acetylcholine (ACh 0.3 μg/kg) and to reactive hyperemia was reduced by 87 and 95%, respectively. In contrast, vasodilation of large coronary arteries induced by hydralazine and NTG was only minimally and similarly affected (-19% for both drugs). These findings demonstrate that in vivo hydralazine-induced dilation of large coronary arteries is endothelium independent.</description><identifier>ISSN: 0160-2446</identifier><identifier>EISSN: 1533-4023</identifier><identifier>DOI: 10.1097/00005344-199402000-00020</identifier><identifier>PMID: 7511763</identifier><identifier>CODEN: JCPCDT</identifier><language>eng</language><publisher>Philadelphia, PA: Lippincott-Raven Publishers</publisher><subject>Angioplasty, Balloon ; Animals ; Antianginal agents. Coronary vasodilator agents ; Biological and medical sciences ; Cardiovascular system ; Coronary Circulation - drug effects ; Coronary Vessels - anatomy & histology ; Coronary Vessels - drug effects ; Dogs ; Dose-Response Relationship, Drug ; Endothelium, Vascular - physiology ; Hydralazine - pharmacology ; Medical sciences ; Nitroglycerin - pharmacology ; Pharmacology. Drug treatments ; Vasodilator Agents - pharmacology</subject><ispartof>Journal of cardiovascular pharmacology, 1994-02, Vol.23 (2), p.315-318</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3660-2d131033df53bcea0492b83346a0ea0e57a2cbb62e8822aebd151c97386dc9bd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf><![CDATA[$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&PDF=y&D=ovft&AN=00005344-199402000-00020$$EPDF$$P50$$Gwolterskluwer$$H]]></linktopdf><linktohtml>$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00005344-199402000-00020$$EHTML$$P50$$Gwolterskluwer$$H</linktohtml><link.rule.ids>315,781,785,4610,27929,27930,64671,65466</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3903254$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7511763$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>la Rochelle, C Drieu</creatorcontrib><creatorcontrib>Dubois-Randé, J L</creatorcontrib><creatorcontrib>Hittinger, L</creatorcontrib><creatorcontrib>Richard, V</creatorcontrib><creatorcontrib>Berdeaux, A</creatorcontrib><creatorcontrib>Giudicelli, J F</creatorcontrib><title>Hydralazine Dilates Large Epicardial Coronary Arteries in Conscious Dogs Through an Endothelium-Independent Mechanism</title><title>Journal of cardiovascular pharmacology</title><addtitle>J Cardiovasc Pharmacol</addtitle><description>SUMMARYIn chronically instrumented conscious dogs, hydralazine (30–300 μg/kg) and nitroglycerin (NTG 0.03–10 μg/kg) dose-dependently dilated large epicardial coronary arteries. Simultaneously, hydralazine also dose-dependently dilated small coronary arteries, whereas a similar effect was observed only after NTG ≥0.3 μg/kg. When large coronary arteries were deendothelialized by a balloon angioplasty catheter, dilation of large coronary arteries in response to acetylcholine (ACh 0.3 μg/kg) and to reactive hyperemia was reduced by 87 and 95%, respectively. In contrast, vasodilation of large coronary arteries induced by hydralazine and NTG was only minimally and similarly affected (-19% for both drugs). These findings demonstrate that in vivo hydralazine-induced dilation of large coronary arteries is endothelium independent.</description><subject>Angioplasty, Balloon</subject><subject>Animals</subject><subject>Antianginal agents. Coronary vasodilator agents</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular system</subject><subject>Coronary Circulation - drug effects</subject><subject>Coronary Vessels - anatomy & histology</subject><subject>Coronary Vessels - drug effects</subject><subject>Dogs</subject><subject>Dose-Response Relationship, Drug</subject><subject>Endothelium, Vascular - physiology</subject><subject>Hydralazine - pharmacology</subject><subject>Medical sciences</subject><subject>Nitroglycerin - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Vasodilator Agents - pharmacology</subject><issn>0160-2446</issn><issn>1533-4023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kVFvFCEQx4nR1LP6EUx4ML5tBYZldx-b62mbnPGlPhMW5m5Rlj1hN0399KW9894kGcjM_IYZ_hBCObvirGu-sLJqkLLiXSeZKF5VTLBXZMVrgKrE4DVZMa5YJaRUb8m7nH8xxmXdqAty0dScNwpWZLl9dMkE89dHpDc-mBkz3Zq0R7o5eGuS8ybQ9ZSmaNIjvU4zJl8QH0swZuunJdObaZ_p_ZCmZT9QE-kmumkeMPhlrO6iwwOWLc70O9rBRJ_H9-TNzoSMH07nJfn5dXO_vq22P77dra-3lQX1PLnjwBmA29XQWzRMdqJvAaQyrHhYN0bYvlcC21YIg73jNbddA61ytusdXJLPx3sPafqzYJ716LPFEEzEMrhulOQgAArYHkGbppwT7vQh-bG8WHOmnxXX_xTXZ8X1i-Kl9OOpx9KP6M6FJ4lL_tMpb7I1YZdMtD6fMegYiFoWTB6xhykUjfPvsDxg0gOaMA_6f_8NT6xTmSs</recordid><startdate>199402</startdate><enddate>199402</enddate><creator>la Rochelle, C Drieu</creator><creator>Dubois-Randé, J L</creator><creator>Hittinger, L</creator><creator>Richard, V</creator><creator>Berdeaux, A</creator><creator>Giudicelli, J F</creator><general>Lippincott-Raven Publishers</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199402</creationdate><title>Hydralazine Dilates Large Epicardial Coronary Arteries in Conscious Dogs Through an Endothelium-Independent Mechanism</title><author>la Rochelle, C Drieu ; Dubois-Randé, J L ; Hittinger, L ; Richard, V ; Berdeaux, A ; Giudicelli, J F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3660-2d131033df53bcea0492b83346a0ea0e57a2cbb62e8822aebd151c97386dc9bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Angioplasty, Balloon</topic><topic>Animals</topic><topic>Antianginal agents. Coronary vasodilator agents</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular system</topic><topic>Coronary Circulation - drug effects</topic><topic>Coronary Vessels - anatomy & histology</topic><topic>Coronary Vessels - drug effects</topic><topic>Dogs</topic><topic>Dose-Response Relationship, Drug</topic><topic>Endothelium, Vascular - physiology</topic><topic>Hydralazine - pharmacology</topic><topic>Medical sciences</topic><topic>Nitroglycerin - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Vasodilator Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>la Rochelle, C Drieu</creatorcontrib><creatorcontrib>Dubois-Randé, J L</creatorcontrib><creatorcontrib>Hittinger, L</creatorcontrib><creatorcontrib>Richard, V</creatorcontrib><creatorcontrib>Berdeaux, A</creatorcontrib><creatorcontrib>Giudicelli, J F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiovascular pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>la Rochelle, C Drieu</au><au>Dubois-Randé, J L</au><au>Hittinger, L</au><au>Richard, V</au><au>Berdeaux, A</au><au>Giudicelli, J F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hydralazine Dilates Large Epicardial Coronary Arteries in Conscious Dogs Through an Endothelium-Independent Mechanism</atitle><jtitle>Journal of cardiovascular pharmacology</jtitle><addtitle>J Cardiovasc Pharmacol</addtitle><date>1994-02</date><risdate>1994</risdate><volume>23</volume><issue>2</issue><spage>315</spage><epage>318</epage><pages>315-318</pages><issn>0160-2446</issn><eissn>1533-4023</eissn><coden>JCPCDT</coden><abstract>SUMMARYIn chronically instrumented conscious dogs, hydralazine (30–300 μg/kg) and nitroglycerin (NTG 0.03–10 μg/kg) dose-dependently dilated large epicardial coronary arteries. Simultaneously, hydralazine also dose-dependently dilated small coronary arteries, whereas a similar effect was observed only after NTG ≥0.3 μg/kg. When large coronary arteries were deendothelialized by a balloon angioplasty catheter, dilation of large coronary arteries in response to acetylcholine (ACh 0.3 μg/kg) and to reactive hyperemia was reduced by 87 and 95%, respectively. In contrast, vasodilation of large coronary arteries induced by hydralazine and NTG was only minimally and similarly affected (-19% for both drugs). These findings demonstrate that in vivo hydralazine-induced dilation of large coronary arteries is endothelium independent.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>7511763</pmid><doi>10.1097/00005344-199402000-00020</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; Journals@Ovid LWW Legacy Archive; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
subjects | Angioplasty, Balloon Animals Antianginal agents. Coronary vasodilator agents Biological and medical sciences Cardiovascular system Coronary Circulation - drug effects Coronary Vessels - anatomy & histology Coronary Vessels - drug effects Dogs Dose-Response Relationship, Drug Endothelium, Vascular - physiology Hydralazine - pharmacology Medical sciences Nitroglycerin - pharmacology Pharmacology. Drug treatments Vasodilator Agents - pharmacology |
title | Hydralazine Dilates Large Epicardial Coronary Arteries in Conscious Dogs Through an Endothelium-Independent Mechanism |
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