Antagonism of substance P and related peptides by RP 67580 and CP-96,345 at tachykinin NK1 receptor sites, in the rat urinary bladder

Tonic contraction of rat urinary bladder was elicited in vitro and in vivo by substance P, two selective NK1 receptor agonists, septide ([pGlu6,Pro9]substance P-(6-11)) and [Sar9,Met(O2)11]substance P, and an NK2 agonist, [Lys5,MeLeu9,Nle10]neurokinin A-(4-10), but not by senktide (succinyl[Asp6,MeP...

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Veröffentlicht in:	European journal of pharmacology 1994-01, Vol.251 (1), p.9-14
Hauptverfasser:	MONTIER, F, CARRUETTE, A, MOUSSAOUI, S, BOCCIO, D, GARRET, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biphenyl Compounds - pharmacology Blood Proteins - metabolism Female Fundamental and applied biological sciences. Psychology Hypnotics and Sedatives - pharmacology In Vitro Techniques Indoles - pharmacology Isoindoles Male Muscle Contraction - drug effects Muscle, Smooth - drug effects Rats Rats, Sprague-Dawley Receptors, Neurokinin-1 - drug effects Substance P - analogs & derivatives Substance P - antagonists & inhibitors Substance P - pharmacology Urinary Bladder - drug effects Vertebrates: urinary system
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