Antinociceptive effect of lipopolysaccharide from Pantoea agglomerans on streptozotocin-induced diabetic mice
The antinociceptive effect of lipopolysaccharide from Pantoea agglomerans (LPSp) in streptozotocin-induced diabetic mice was examined. Although subcutaneous (s.c.) administration of LPSp produced a dose-dependent inhibition of the tail-flick response in both non-diabetic and diabetic mice, the antin...
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| Veröffentlicht in: | European journal of pharmacology 1994-01, Vol.251 (1), p.95-98 |
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| container_title | European journal of pharmacology |
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| creator | Kamei, Junzo Iwamoto, Yuriko Suzuki, Tsutomu Misawa, Miwa Kasuya, Yutaka Nagase, Hiroshi Okutomi, Takafumi Soma, Gen-Ichiro Mizuno, Den'ichi |
| description | The antinociceptive effect of lipopolysaccharide from
Pantoea agglomerans (LPSp) in streptozotocin-induced diabetic mice was examined. Although subcutaneous (s.c.) administration of LPSp produced a dose-dependent inhibition of the tail-flick response in both non-diabetic and diabetic mice, the antinociceptive response was greater in diabetic mice than in non-diabetic mice. The antinociceptive effects of LPSp in both diabetic and non-diabetic mice were significantly antagonized by s.c. administration of naltrindole, a selective δ-opioid receptor antagonist or nor-binaltorphimine, a selective κ-opioid receptor antagonist, but not by β-funaltrexamine, a selective μ-opioid receptor antagonist. These results suggest that LPSp produces a marked antinociceptive effect in diabetic mice through the activation of δ- and κ-opioid receptors. |
| doi_str_mv | 10.1016/0014-2999(94)90448-0 |
| format | Article |
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Pantoea agglomerans (LPSp) in streptozotocin-induced diabetic mice was examined. Although subcutaneous (s.c.) administration of LPSp produced a dose-dependent inhibition of the tail-flick response in both non-diabetic and diabetic mice, the antinociceptive response was greater in diabetic mice than in non-diabetic mice. The antinociceptive effects of LPSp in both diabetic and non-diabetic mice were significantly antagonized by s.c. administration of naltrindole, a selective δ-opioid receptor antagonist or nor-binaltorphimine, a selective κ-opioid receptor antagonist, but not by β-funaltrexamine, a selective μ-opioid receptor antagonist. These results suggest that LPSp produces a marked antinociceptive effect in diabetic mice through the activation of δ- and κ-opioid receptors.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(94)90448-0</identifier><identifier>PMID: 8137875</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analgesics ; Analgesics - antagonists & inhibitors ; Analgesics - pharmacology ; Animals ; Antinociception ; Biological and medical sciences ; Diabetes ; Diabetes Mellitus, Experimental - psychology ; Dose-Response Relationship, Drug ; Enterobacter ; Injections, Subcutaneous ; Lipopolysaccharide, Pantoea agglomerans ; Lipopolysaccharides - pharmacology ; Male ; Medical sciences ; Mice ; Mice, Inbred ICR ; Naltrexone - analogs & derivatives ; Naltrexone - pharmacology ; Naltrindole ; Narcotic Antagonists - pharmacology ; Neuropharmacology ; Nor-binaltorphimine ; Opioid receptor ; Pain Measurement - drug effects ; Pharmacology. Drug treatments ; β-Funaltrexamine</subject><ispartof>European journal of pharmacology, 1994-01, Vol.251 (1), p.95-98</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-cb49eadf5f99fa809c3134930886b8cbfd7f464e8f0b9817115a82ca1b8c9c343</citedby><cites>FETCH-LOGICAL-c448t-cb49eadf5f99fa809c3134930886b8cbfd7f464e8f0b9817115a82ca1b8c9c343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-2999(94)90448-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3918911$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8137875$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kamei, Junzo</creatorcontrib><creatorcontrib>Iwamoto, Yuriko</creatorcontrib><creatorcontrib>Suzuki, Tsutomu</creatorcontrib><creatorcontrib>Misawa, Miwa</creatorcontrib><creatorcontrib>Kasuya, Yutaka</creatorcontrib><creatorcontrib>Nagase, Hiroshi</creatorcontrib><creatorcontrib>Okutomi, Takafumi</creatorcontrib><creatorcontrib>Soma, Gen-Ichiro</creatorcontrib><creatorcontrib>Mizuno, Den'ichi</creatorcontrib><title>Antinociceptive effect of lipopolysaccharide from Pantoea agglomerans on streptozotocin-induced diabetic mice</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>The antinociceptive effect of lipopolysaccharide from
Pantoea agglomerans (LPSp) in streptozotocin-induced diabetic mice was examined. Although subcutaneous (s.c.) administration of LPSp produced a dose-dependent inhibition of the tail-flick response in both non-diabetic and diabetic mice, the antinociceptive response was greater in diabetic mice than in non-diabetic mice. The antinociceptive effects of LPSp in both diabetic and non-diabetic mice were significantly antagonized by s.c. administration of naltrindole, a selective δ-opioid receptor antagonist or nor-binaltorphimine, a selective κ-opioid receptor antagonist, but not by β-funaltrexamine, a selective μ-opioid receptor antagonist. These results suggest that LPSp produces a marked antinociceptive effect in diabetic mice through the activation of δ- and κ-opioid receptors.</description><subject>Analgesics</subject><subject>Analgesics - antagonists & inhibitors</subject><subject>Analgesics - pharmacology</subject><subject>Animals</subject><subject>Antinociception</subject><subject>Biological and medical sciences</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Experimental - psychology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Enterobacter</subject><subject>Injections, Subcutaneous</subject><subject>Lipopolysaccharide, Pantoea agglomerans</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Naltrexone - analogs & derivatives</subject><subject>Naltrexone - pharmacology</subject><subject>Naltrindole</subject><subject>Narcotic Antagonists - pharmacology</subject><subject>Neuropharmacology</subject><subject>Nor-binaltorphimine</subject><subject>Opioid receptor</subject><subject>Pain Measurement - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>β-Funaltrexamine</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi0EKtvCPwDJB4TKIcWTOInnglRV5UOqVA5wthxnXIySONjeSuXX18uu9gicfJhnXs_Mw9grEBcgoHsvBMiqRsRzlO9QSKkq8YRtQPVYiR7qp2xzRJ6z05R-CiFarNsTdqKg6VXfbth8uWS_BOstrdnfEyfnyGYeHJ_8GtYwPSRj7Q8T_UjcxTDzr2bJgQw3d3dTmCmaJfGw8JRjiQi_Qy5pS-WXcWtp5KM3A2Vv-Vy-eMGeOTMlenl4z9j3j9ffrj5XN7efvlxd3lS2bJErO0gkM7rWITqjBNoGGomNUKoblB3c2DvZSVJODKigB2iNqq2BUiysbM7Y233uGsOvLaWsZ58sTZNZKGyT7jsJUAv8JwgdNnXdtP8BKiXL8AWUe9DGkFIkp9foZxMfNAi986Z3UvROikap_3jTorS9PuRvh5nGY9NBVKm_OdRNsmZy5erWpyPWICgEKNiHPUbluveeok7W01JE-Fi06jH4v8_xCPBKtd0</recordid><startdate>19940104</startdate><enddate>19940104</enddate><creator>Kamei, Junzo</creator><creator>Iwamoto, Yuriko</creator><creator>Suzuki, Tsutomu</creator><creator>Misawa, Miwa</creator><creator>Kasuya, Yutaka</creator><creator>Nagase, Hiroshi</creator><creator>Okutomi, Takafumi</creator><creator>Soma, Gen-Ichiro</creator><creator>Mizuno, Den'ichi</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19940104</creationdate><title>Antinociceptive effect of lipopolysaccharide from Pantoea agglomerans on streptozotocin-induced diabetic mice</title><author>Kamei, Junzo ; Iwamoto, Yuriko ; Suzuki, Tsutomu ; Misawa, Miwa ; Kasuya, Yutaka ; Nagase, Hiroshi ; Okutomi, Takafumi ; Soma, Gen-Ichiro ; Mizuno, Den'ichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-cb49eadf5f99fa809c3134930886b8cbfd7f464e8f0b9817115a82ca1b8c9c343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Analgesics</topic><topic>Analgesics - antagonists & inhibitors</topic><topic>Analgesics - pharmacology</topic><topic>Animals</topic><topic>Antinociception</topic><topic>Biological and medical sciences</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Experimental - psychology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Enterobacter</topic><topic>Injections, Subcutaneous</topic><topic>Lipopolysaccharide, Pantoea agglomerans</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Naltrexone - analogs & derivatives</topic><topic>Naltrexone - pharmacology</topic><topic>Naltrindole</topic><topic>Narcotic Antagonists - pharmacology</topic><topic>Neuropharmacology</topic><topic>Nor-binaltorphimine</topic><topic>Opioid receptor</topic><topic>Pain Measurement - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>β-Funaltrexamine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kamei, Junzo</creatorcontrib><creatorcontrib>Iwamoto, Yuriko</creatorcontrib><creatorcontrib>Suzuki, Tsutomu</creatorcontrib><creatorcontrib>Misawa, Miwa</creatorcontrib><creatorcontrib>Kasuya, Yutaka</creatorcontrib><creatorcontrib>Nagase, Hiroshi</creatorcontrib><creatorcontrib>Okutomi, Takafumi</creatorcontrib><creatorcontrib>Soma, Gen-Ichiro</creatorcontrib><creatorcontrib>Mizuno, Den'ichi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kamei, Junzo</au><au>Iwamoto, Yuriko</au><au>Suzuki, Tsutomu</au><au>Misawa, Miwa</au><au>Kasuya, Yutaka</au><au>Nagase, Hiroshi</au><au>Okutomi, Takafumi</au><au>Soma, Gen-Ichiro</au><au>Mizuno, Den'ichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antinociceptive effect of lipopolysaccharide from Pantoea agglomerans on streptozotocin-induced diabetic mice</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1994-01-04</date><risdate>1994</risdate><volume>251</volume><issue>1</issue><spage>95</spage><epage>98</epage><pages>95-98</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>The antinociceptive effect of lipopolysaccharide from
Pantoea agglomerans (LPSp) in streptozotocin-induced diabetic mice was examined. Although subcutaneous (s.c.) administration of LPSp produced a dose-dependent inhibition of the tail-flick response in both non-diabetic and diabetic mice, the antinociceptive response was greater in diabetic mice than in non-diabetic mice. The antinociceptive effects of LPSp in both diabetic and non-diabetic mice were significantly antagonized by s.c. administration of naltrindole, a selective δ-opioid receptor antagonist or nor-binaltorphimine, a selective κ-opioid receptor antagonist, but not by β-funaltrexamine, a selective μ-opioid receptor antagonist. These results suggest that LPSp produces a marked antinociceptive effect in diabetic mice through the activation of δ- and κ-opioid receptors.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>8137875</pmid><doi>10.1016/0014-2999(94)90448-0</doi><tpages>4</tpages></addata></record> |
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| ispartof | European journal of pharmacology, 1994-01, Vol.251 (1), p.95-98 |
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| subjects | Analgesics Analgesics - antagonists & inhibitors Analgesics - pharmacology Animals Antinociception Biological and medical sciences Diabetes Diabetes Mellitus, Experimental - psychology Dose-Response Relationship, Drug Enterobacter Injections, Subcutaneous Lipopolysaccharide, Pantoea agglomerans Lipopolysaccharides - pharmacology Male Medical sciences Mice Mice, Inbred ICR Naltrexone - analogs & derivatives Naltrexone - pharmacology Naltrindole Narcotic Antagonists - pharmacology Neuropharmacology Nor-binaltorphimine Opioid receptor Pain Measurement - drug effects Pharmacology. Drug treatments β-Funaltrexamine |
| title | Antinociceptive effect of lipopolysaccharide from Pantoea agglomerans on streptozotocin-induced diabetic mice |
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