Epristeride is a selective and specific uncompetitive inhibitor of human steroid 5α-reductase isoform 2

Specificity of an enzyme inhibitor can have profound implications upon the compound's therapeutic potential, utility and safety profile. As potent inhibitors of human steroid 5α-reductase (SR) the 3-androstene-3-carboxylic acids, or steroidal acrylates, may be useful in treatment of diseases su...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 1994-02, Vol.48 (2), p.197-206
Hauptverfasser:	Levy, Mark A., Brandt, Martin, Sheedy, Kristina M., Dinh, Jeffrey T., Holt, Dennis A., Garrison, Linda M., Bergsma, Derk J., Metcalf, Brian W.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism 5-alpha Reductase Inhibitors Androstadienes - metabolism Androstadienes - pharmacology Animals Biological and medical sciences Hormones. Endocrine system Humans Isoenzymes - antagonists & inhibitors Liver - enzymology Male Medical sciences NADP - metabolism Pharmacology. Drug treatments Rats Recombinant Proteins - antagonists & inhibitors
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