Acidic fibroblast growth factor : evaluation of topical formulations in a diabetic mouse wound healing model

The efficacy of topical formulations of acidic fibroblast growth factor (aFGF) in healing of full-thickness wounds has been studied in a diabetic db+/db+ mouse model. The effect of several formulation variables, dose, and application frequency was examined. It was found that wound healing in diabeti...

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Veröffentlicht in:	Pharmaceutical research 1994, Vol.11 (1), p.65-71
Hauptverfasser:	MATUSZEWSKA, B, KEOGAN, M, FISHER, D. M, SOPER, K. A, CHAO-MIN HOE, HUBER, A. C, BONDI, J. V
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Animals Biological and medical sciences Blood Glucose - metabolism Cellulose - analogs & derivatives Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism Excipients Female Fibroblast Growth Factor 1 - administration & dosage Fibroblast Growth Factor 1 - pharmacokinetics Heparin - chemistry Medical sciences Mice Mice, Inbred C57BL Pharmacology. Drug treatments Recombinant Proteins - administration & dosage Recombinant Proteins - pharmacokinetics Skin, nail, hair, dermoskeleton Wound Healing - drug effects
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