Serum and peritoneal fluid CA-125 levels in patients with endometriosis
To evaluate CA-125 in peritoneal fluid (PF) as an indicator of endometriosis. CA-125 levels in paired serum and PF were determined by the one-step immunoradiometric assay. For peritoneal samples, high dilution of the sample (1:100) was used to avoid false low results, caused by the “hook effect” phe...
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| Veröffentlicht in: | Fertility and sterility 1994-03, Vol.61 (3), p.438-442 |
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| container_title | Fertility and sterility |
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| creator | Barbati, Antonella Cosmi, Ermelando Vinicio Spaziani, Rita Ventura, Rocco Montanino, Gennaro |
| description | To evaluate CA-125 in peritoneal fluid (PF) as an indicator of endometriosis.
CA-125 levels in paired serum and PF were determined by the one-step immunoradiometric assay. For peritoneal samples, high dilution of the sample (1:100) was used to avoid false low results, caused by the “hook effect” phenomenon.
Forty-one women with and without endometriosis, undergoing laparoscopy or laparotomy during the follicular phase of the menstrual cycle, were selected.
2nd Institute of Obstetrics and Gynecology, University of Rome “La Sapienza,” Rome, Italy.
Peritoneal fluid CA-125 levels obtained using diluted samples were significantly higher than those found using undiluted ones.
CA-125 levels in PF were approximately 100 times higher than those found in paired serum, ranging from 970 to 10,636 U/mL. In patients with endometriosis, CA-125 levels in PF were significantly elevated when compared with the control group. In serum, CA-125 levels increased only in advanced stages of endometriosis.
The sensitivity of the CA-125 test for endometriosis in PF is greater than in serum. Therefore, the measurement of CA-125 levels in PF could be useful in the detection of early stage endometriosis, which tends to be overlooked by the CA-125 serum test. |
| doi_str_mv | 10.1016/S0015-0282(16)56572-8 |
| format | Article |
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CA-125 levels in paired serum and PF were determined by the one-step immunoradiometric assay. For peritoneal samples, high dilution of the sample (1:100) was used to avoid false low results, caused by the “hook effect” phenomenon.
Forty-one women with and without endometriosis, undergoing laparoscopy or laparotomy during the follicular phase of the menstrual cycle, were selected.
2nd Institute of Obstetrics and Gynecology, University of Rome “La Sapienza,” Rome, Italy.
Peritoneal fluid CA-125 levels obtained using diluted samples were significantly higher than those found using undiluted ones.
CA-125 levels in PF were approximately 100 times higher than those found in paired serum, ranging from 970 to 10,636 U/mL. In patients with endometriosis, CA-125 levels in PF were significantly elevated when compared with the control group. In serum, CA-125 levels increased only in advanced stages of endometriosis.
The sensitivity of the CA-125 test for endometriosis in PF is greater than in serum. Therefore, the measurement of CA-125 levels in PF could be useful in the detection of early stage endometriosis, which tends to be overlooked by the CA-125 serum test.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(16)56572-8</identifier><identifier>PMID: 8137963</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Antigens, Tumor-Associated, Carbohydrate - blood ; Antigens, Tumor-Associated, Carbohydrate - metabolism ; Ascitic Fluid - metabolism ; Biological and medical sciences ; CA-125 ; endometriosis ; Endometriosis - metabolism ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; hook effect ; Humans ; Immunoradiometric Assay ; Medical sciences ; Middle Aged ; Non tumoral diseases ; peritoneal fluid ; Reference Values</subject><ispartof>Fertility and sterility, 1994-03, Vol.61 (3), p.438-442</ispartof><rights>1994 American Society for Reproductive Medicine</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-aec8e418d45dbc0b67306d9615d84bbee36185b24023afbf4e2bcb9c783ae0683</citedby><cites>FETCH-LOGICAL-c436t-aec8e418d45dbc0b67306d9615d84bbee36185b24023afbf4e2bcb9c783ae0683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0015-0282(16)56572-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3981622$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8137963$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barbati, Antonella</creatorcontrib><creatorcontrib>Cosmi, Ermelando Vinicio</creatorcontrib><creatorcontrib>Spaziani, Rita</creatorcontrib><creatorcontrib>Ventura, Rocco</creatorcontrib><creatorcontrib>Montanino, Gennaro</creatorcontrib><title>Serum and peritoneal fluid CA-125 levels in patients with endometriosis</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>To evaluate CA-125 in peritoneal fluid (PF) as an indicator of endometriosis.
CA-125 levels in paired serum and PF were determined by the one-step immunoradiometric assay. For peritoneal samples, high dilution of the sample (1:100) was used to avoid false low results, caused by the “hook effect” phenomenon.
Forty-one women with and without endometriosis, undergoing laparoscopy or laparotomy during the follicular phase of the menstrual cycle, were selected.
2nd Institute of Obstetrics and Gynecology, University of Rome “La Sapienza,” Rome, Italy.
Peritoneal fluid CA-125 levels obtained using diluted samples were significantly higher than those found using undiluted ones.
CA-125 levels in PF were approximately 100 times higher than those found in paired serum, ranging from 970 to 10,636 U/mL. In patients with endometriosis, CA-125 levels in PF were significantly elevated when compared with the control group. In serum, CA-125 levels increased only in advanced stages of endometriosis.
The sensitivity of the CA-125 test for endometriosis in PF is greater than in serum. Therefore, the measurement of CA-125 levels in PF could be useful in the detection of early stage endometriosis, which tends to be overlooked by the CA-125 serum test.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Antigens, Tumor-Associated, Carbohydrate - blood</subject><subject>Antigens, Tumor-Associated, Carbohydrate - metabolism</subject><subject>Ascitic Fluid - metabolism</subject><subject>Biological and medical sciences</subject><subject>CA-125</subject><subject>endometriosis</subject><subject>Endometriosis - metabolism</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>hook effect</subject><subject>Humans</subject><subject>Immunoradiometric Assay</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Non tumoral diseases</subject><subject>peritoneal fluid</subject><subject>Reference Values</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKAzEUhoMotVYfoZCFiC5Gc5lk0pWU4g0KLtR1yOUMRuZSkxnFt3dqh25dHX7Ody58CM0puaaEypsXQqjICFPsksorIUXBMnWAplQImQ2RH6LpHjlGJyl9EEIkLdgETRTlxULyKXp4gdjX2DQebyCGrm3AVLis-uDxaplRJnAFX1AlHBq8MV2Apkv4O3TvGBrf1tDF0KaQTtFRaaoEZ2Odobf7u9fVY7Z-fnhaLdeZy7nsMgNOQU6Vz4W3jlhZcCL9QlLhVW4tAJdUCctywrgpbZkDs84uXKG4ASIVn6GL3d5NbD97SJ2uQ3JQVaaBtk-6kDklRMgBFDvQxTalCKXexFCb-KMp0VuB-k-g3trRQ_oTqLcH5uOB3tbg91OjsaF_PvZNcqYqo2lcSHuMLxSVjA3Y7Q4b1MFXgKiTG9w58CGC67Rvwz-P_AJSqIv5</recordid><startdate>19940301</startdate><enddate>19940301</enddate><creator>Barbati, Antonella</creator><creator>Cosmi, Ermelando Vinicio</creator><creator>Spaziani, Rita</creator><creator>Ventura, Rocco</creator><creator>Montanino, Gennaro</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940301</creationdate><title>Serum and peritoneal fluid CA-125 levels in patients with endometriosis</title><author>Barbati, Antonella ; Cosmi, Ermelando Vinicio ; Spaziani, Rita ; Ventura, Rocco ; Montanino, Gennaro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-aec8e418d45dbc0b67306d9615d84bbee36185b24023afbf4e2bcb9c783ae0683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Antigens, Tumor-Associated, Carbohydrate - blood</topic><topic>Antigens, Tumor-Associated, Carbohydrate - metabolism</topic><topic>Ascitic Fluid - metabolism</topic><topic>Biological and medical sciences</topic><topic>CA-125</topic><topic>endometriosis</topic><topic>Endometriosis - metabolism</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>hook effect</topic><topic>Humans</topic><topic>Immunoradiometric Assay</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Non tumoral diseases</topic><topic>peritoneal fluid</topic><topic>Reference Values</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barbati, Antonella</creatorcontrib><creatorcontrib>Cosmi, Ermelando Vinicio</creatorcontrib><creatorcontrib>Spaziani, Rita</creatorcontrib><creatorcontrib>Ventura, Rocco</creatorcontrib><creatorcontrib>Montanino, Gennaro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barbati, Antonella</au><au>Cosmi, Ermelando Vinicio</au><au>Spaziani, Rita</au><au>Ventura, Rocco</au><au>Montanino, Gennaro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum and peritoneal fluid CA-125 levels in patients with endometriosis</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>1994-03-01</date><risdate>1994</risdate><volume>61</volume><issue>3</issue><spage>438</spage><epage>442</epage><pages>438-442</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>To evaluate CA-125 in peritoneal fluid (PF) as an indicator of endometriosis.
CA-125 levels in paired serum and PF were determined by the one-step immunoradiometric assay. For peritoneal samples, high dilution of the sample (1:100) was used to avoid false low results, caused by the “hook effect” phenomenon.
Forty-one women with and without endometriosis, undergoing laparoscopy or laparotomy during the follicular phase of the menstrual cycle, were selected.
2nd Institute of Obstetrics and Gynecology, University of Rome “La Sapienza,” Rome, Italy.
Peritoneal fluid CA-125 levels obtained using diluted samples were significantly higher than those found using undiluted ones.
CA-125 levels in PF were approximately 100 times higher than those found in paired serum, ranging from 970 to 10,636 U/mL. In patients with endometriosis, CA-125 levels in PF were significantly elevated when compared with the control group. In serum, CA-125 levels increased only in advanced stages of endometriosis.
The sensitivity of the CA-125 test for endometriosis in PF is greater than in serum. Therefore, the measurement of CA-125 levels in PF could be useful in the detection of early stage endometriosis, which tends to be overlooked by the CA-125 serum test.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8137963</pmid><doi>10.1016/S0015-0282(16)56572-8</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Antigens, Tumor-Associated, Carbohydrate - blood Antigens, Tumor-Associated, Carbohydrate - metabolism Ascitic Fluid - metabolism Biological and medical sciences CA-125 endometriosis Endometriosis - metabolism Female Female genital diseases Gynecology. Andrology. Obstetrics hook effect Humans Immunoradiometric Assay Medical sciences Middle Aged Non tumoral diseases peritoneal fluid Reference Values |
| title | Serum and peritoneal fluid CA-125 levels in patients with endometriosis |
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