High Frequency of B Cells Capable of Producing Anti-Thyrotropin Receptor Antibodies in Patients with Graves' Disease

Hyperthyroidism in Graves' disease (GD) is mediated by antibodies to the thyrotropin receptor (TSHr). Patients that go into remission show a decline in antibody titer. However, upon cessation of treatment with anti-thyroid drugs a significant proportion of patients relapse and TSHr antibodies (...

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Veröffentlicht in:	Clinical immunology and immunopathology 1994-04, Vol.71 (1), p.69-74
Hauptverfasser:	Fan, Ji-Lao, Desai, Rajesh K., Dallas, John S., Wagle, Neelam M., Seetharamaiah, Gattadahalli S., Prabhakar, Bellur S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antibody Formation Autoantibodies - immunology B-Lymphocytes - immunology B-Lymphocytes - metabolism Biological and medical sciences Cells, Cultured Child Endocrinopathies Female Graves Disease - immunology Humans Lymphocyte Activation Male Medical sciences Middle Aged Non tumoral diseases. Target tissue resistance. Benign neoplasms Receptors, Thyrotropin - immunology Thyroid. Thyroid axis (diseases)
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