Influence of Ca and Mg on the uptake and deposition of Pb and Cd in mice
The influence of high but not extreme concentrations of Ca and Mg (25 μmol/ml) on the apparent absorption and retention of 203Pb and 115mCd from water was investigated in mice. Ca reduced the absorption of Pb from an intubated solution by 62% and the absorption of Cd by 22%, but these effects were n...
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| Veröffentlicht in: | Toxicology and applied pharmacology 1985-06, Vol.79 (1), p.1-10 |
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| creator | Van Barneveld, Abraham A. Van den Hamer, Cornelis J.A. |
| description | The influence of high but not extreme concentrations of Ca and Mg (25 μmol/ml) on the apparent absorption and retention of
203Pb and
115mCd from water was investigated in mice. Ca reduced the absorption of Pb from an intubated solution by 62% and the absorption of Cd by 22%, but these effects were not significant. Mg showed no effect on Pb and Cd absorption. The retention of ip-injected Pb and Cd was not influenced by addition of Ca or Mg to the drinking water. Feeding of a Ca-deprived diet for 2 weeks prior to dosage stimulated the absorption of Pb from water by more than 100% (
p < 0.01) and the absorption of Cd from water by 17% (
p < 0.05). Feeding of a Ca-supplemented diet did not influence the absorption of Pb or Cd, but fecal Cd excretion seemed to be reduced. Feeding of Mg-deprived or Mg-supplemented diets did not show any effect on Pb and Cd metabolism. These results give supporting evidence that in soft water regions the uptake of Pb from the drinking water could be increased because of the absence of Ca in the drinking water, particularly when dietary Ca intake is low. This relationship between drinking water hardness and absorption of Pb could be important in view of general public health. |
| doi_str_mv | 10.1016/0041-008X(85)90363-1 |
| format | Article |
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203Pb and
115mCd from water was investigated in mice. Ca reduced the absorption of Pb from an intubated solution by 62% and the absorption of Cd by 22%, but these effects were not significant. Mg showed no effect on Pb and Cd absorption. The retention of ip-injected Pb and Cd was not influenced by addition of Ca or Mg to the drinking water. Feeding of a Ca-deprived diet for 2 weeks prior to dosage stimulated the absorption of Pb from water by more than 100% (
p < 0.01) and the absorption of Cd from water by 17% (
p < 0.05). Feeding of a Ca-supplemented diet did not influence the absorption of Pb or Cd, but fecal Cd excretion seemed to be reduced. Feeding of Mg-deprived or Mg-supplemented diets did not show any effect on Pb and Cd metabolism. These results give supporting evidence that in soft water regions the uptake of Pb from the drinking water could be increased because of the absence of Ca in the drinking water, particularly when dietary Ca intake is low. This relationship between drinking water hardness and absorption of Pb could be important in view of general public health.</description><identifier>ISSN: 0041-008X</identifier><identifier>EISSN: 1096-0333</identifier><identifier>DOI: 10.1016/0041-008X(85)90363-1</identifier><identifier>PMID: 4049398</identifier><identifier>CODEN: TXAPA9</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Bone and Bones - metabolism ; Cadmium - metabolism ; Calcium - pharmacology ; Chemical and industrial products toxicology. Toxic occupational diseases ; Diet ; Female ; Injections, Intraperitoneal ; Intestinal Absorption - drug effects ; Intubation, Gastrointestinal ; Kidney - metabolism ; Lead - metabolism ; Liver - metabolism ; Magnesium - pharmacology ; Medical sciences ; Metals and various inorganic compounds ; Mice ; Toxicology</subject><ispartof>Toxicology and applied pharmacology, 1985-06, Vol.79 (1), p.1-10</ispartof><rights>1985</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-2a775e02c1ffb76a330f714657b9897692c84f9070ca3ff70f7d4cefa716f21f3</citedby><cites>FETCH-LOGICAL-c386t-2a775e02c1ffb76a330f714657b9897692c84f9070ca3ff70f7d4cefa716f21f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0041-008X(85)90363-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9235632$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4049398$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Van Barneveld, Abraham A.</creatorcontrib><creatorcontrib>Van den Hamer, Cornelis J.A.</creatorcontrib><title>Influence of Ca and Mg on the uptake and deposition of Pb and Cd in mice</title><title>Toxicology and applied pharmacology</title><addtitle>Toxicol Appl Pharmacol</addtitle><description>The influence of high but not extreme concentrations of Ca and Mg (25 μmol/ml) on the apparent absorption and retention of
203Pb and
115mCd from water was investigated in mice. Ca reduced the absorption of Pb from an intubated solution by 62% and the absorption of Cd by 22%, but these effects were not significant. Mg showed no effect on Pb and Cd absorption. The retention of ip-injected Pb and Cd was not influenced by addition of Ca or Mg to the drinking water. Feeding of a Ca-deprived diet for 2 weeks prior to dosage stimulated the absorption of Pb from water by more than 100% (
p < 0.01) and the absorption of Cd from water by 17% (
p < 0.05). Feeding of a Ca-supplemented diet did not influence the absorption of Pb or Cd, but fecal Cd excretion seemed to be reduced. Feeding of Mg-deprived or Mg-supplemented diets did not show any effect on Pb and Cd metabolism. These results give supporting evidence that in soft water regions the uptake of Pb from the drinking water could be increased because of the absence of Ca in the drinking water, particularly when dietary Ca intake is low. This relationship between drinking water hardness and absorption of Pb could be important in view of general public health.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bone and Bones - metabolism</subject><subject>Cadmium - metabolism</subject><subject>Calcium - pharmacology</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Diet</subject><subject>Female</subject><subject>Injections, Intraperitoneal</subject><subject>Intestinal Absorption - drug effects</subject><subject>Intubation, Gastrointestinal</subject><subject>Kidney - metabolism</subject><subject>Lead - metabolism</subject><subject>Liver - metabolism</subject><subject>Magnesium - pharmacology</subject><subject>Medical sciences</subject><subject>Metals and various inorganic compounds</subject><subject>Mice</subject><subject>Toxicology</subject><issn>0041-008X</issn><issn>1096-0333</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKxDAUhoMoOl7eQCELEV1UT5o0aTaCDN5A0YWCu5BJTzTaacemFXx7Mxdm6erA-b9z4SPkkME5AyYvAATLAMq307I408Alz9gGGTHQMgPO-SYZrZEdshvjJwBoIdg22RYgNNfliNzdN74esHFIW0_Hltqmoo_vtG1o_4F0mPX2CxfNCmdtDH1ISSKfJ4vmuKKhodPgcJ9seVtHPFjVPfJ6c_0yvssenm7vx1cPmeOl7LPcKlUg5I55P1HScg5eMSELNdGlVlLnrhRegwJnufcqpZVw6K1i0ufM8z1ystw769rvAWNvpiE6rGvbYDtEo6QAyXORQLEEXdfG2KE3sy5MbfdrGJi5QDO3Y-Z2TFmYhUDD0tjRav8wmWK1HloZS_nxKrfR2dp3tnEhrjGd8yKdT9jlEsPk4idgZ6ILc81V6ND1pmrD_3_8AdQJiaI</recordid><startdate>19850615</startdate><enddate>19850615</enddate><creator>Van Barneveld, Abraham A.</creator><creator>Van den Hamer, Cornelis J.A.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19850615</creationdate><title>Influence of Ca and Mg on the uptake and deposition of Pb and Cd in mice</title><author>Van Barneveld, Abraham A. ; Van den Hamer, Cornelis J.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-2a775e02c1ffb76a330f714657b9897692c84f9070ca3ff70f7d4cefa716f21f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bone and Bones - metabolism</topic><topic>Cadmium - metabolism</topic><topic>Calcium - pharmacology</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Diet</topic><topic>Female</topic><topic>Injections, Intraperitoneal</topic><topic>Intestinal Absorption - drug effects</topic><topic>Intubation, Gastrointestinal</topic><topic>Kidney - metabolism</topic><topic>Lead - metabolism</topic><topic>Liver - metabolism</topic><topic>Magnesium - pharmacology</topic><topic>Medical sciences</topic><topic>Metals and various inorganic compounds</topic><topic>Mice</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van Barneveld, Abraham A.</creatorcontrib><creatorcontrib>Van den Hamer, Cornelis J.A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Toxicology and applied pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van Barneveld, Abraham A.</au><au>Van den Hamer, Cornelis J.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Ca and Mg on the uptake and deposition of Pb and Cd in mice</atitle><jtitle>Toxicology and applied pharmacology</jtitle><addtitle>Toxicol Appl Pharmacol</addtitle><date>1985-06-15</date><risdate>1985</risdate><volume>79</volume><issue>1</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>0041-008X</issn><eissn>1096-0333</eissn><coden>TXAPA9</coden><abstract>The influence of high but not extreme concentrations of Ca and Mg (25 μmol/ml) on the apparent absorption and retention of
203Pb and
115mCd from water was investigated in mice. Ca reduced the absorption of Pb from an intubated solution by 62% and the absorption of Cd by 22%, but these effects were not significant. Mg showed no effect on Pb and Cd absorption. The retention of ip-injected Pb and Cd was not influenced by addition of Ca or Mg to the drinking water. Feeding of a Ca-deprived diet for 2 weeks prior to dosage stimulated the absorption of Pb from water by more than 100% (
p < 0.01) and the absorption of Cd from water by 17% (
p < 0.05). Feeding of a Ca-supplemented diet did not influence the absorption of Pb or Cd, but fecal Cd excretion seemed to be reduced. Feeding of Mg-deprived or Mg-supplemented diets did not show any effect on Pb and Cd metabolism. These results give supporting evidence that in soft water regions the uptake of Pb from the drinking water could be increased because of the absence of Ca in the drinking water, particularly when dietary Ca intake is low. This relationship between drinking water hardness and absorption of Pb could be important in view of general public health.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>4049398</pmid><doi>10.1016/0041-008X(85)90363-1</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0041-008X |
| ispartof | Toxicology and applied pharmacology, 1985-06, Vol.79 (1), p.1-10 |
| issn | 0041-008X 1096-0333 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76406324 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Biological and medical sciences Bone and Bones - metabolism Cadmium - metabolism Calcium - pharmacology Chemical and industrial products toxicology. Toxic occupational diseases Diet Female Injections, Intraperitoneal Intestinal Absorption - drug effects Intubation, Gastrointestinal Kidney - metabolism Lead - metabolism Liver - metabolism Magnesium - pharmacology Medical sciences Metals and various inorganic compounds Mice Toxicology |
| title | Influence of Ca and Mg on the uptake and deposition of Pb and Cd in mice |
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