Expression and Insulin-like Growth Factor-Dependent Proteolysis of Insulin-like Growth Factor-Binding Protein-4 Are Regulated by Cell Confluence in Vascular Smooth Muscle Cells

Insulin-like growth factor (IGF)-I is markedly induced after balloon injury in the rat aorta, where it may serve to mediate vascular repair. Because the bioavailability of IGF-I is modulated by IGF-binding proteins (IGFBPs), we examined the regulation of IGFBPs by IGFs in primary cultures of rat aor...

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Veröffentlicht in:	Circulation research 1994-04, Vol.74 (4), p.576-585
Hauptverfasser:	Kamyar, A, Pirola, C J, Wang, H.-M, Sharifi, B, Mohan, S, Forrester, J S, Fagin, J A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood vessels and receptors Carrier Proteins - genetics Carrier Proteins - metabolism Cells, Cultured Edetic Acid - pharmacology Endopeptidases - physiology Fundamental and applied biological sciences. Psychology Gene Expression Insulin-Like Growth Factor Binding Protein 4 Insulin-Like Growth Factor I - pharmacology Male Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Rats Rats, Sprague-Dawley Vertebrates: cardiovascular system
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