Developmental expression in the rat cerebellum of SC1, a putative brain extracellular matrix glycoprotein related to SPARC
In the nervous system, extracellular matrix (ECM) molecules have been shown to have effects on cell migration, process outgrowth and the survival of neurons. Recently we have described the molecular cloning of SC1, a putative brain extracellular matrix glycoprotein, showing partial similarity to the...
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| Veröffentlicht in: | Brain research 1994-01, Vol.633 (1), p.197-205 |
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| creator | Mendis, Duane B. Shahin, Susan Gurd, James W. Brown, Ian R. |
| description | In the nervous system, extracellular matrix (ECM) molecules have been shown to have effects on cell migration, process outgrowth and the survival of neurons. Recently we have described the molecular cloning of SC1, a putative brain extracellular matrix glycoprotein, showing partial similarity to the ECM glycoprotein SPARC/osteonectin. We have now examined the expression of SC1 during the development of the rat cerebellum at both the protein and mRNA levels. Our results indicate that SC1 is both temporally and spatially regulated during this process. Bergmann glial cells express SC1 mRNA and the resultant protein is deposited along the length of their radial fibres during the process of granule cell migration in the developing cerebellum. SC1 mRNA and protein is also found in the adult cerebellum, concentrated in the Bergmann glial cells and their radial processes, indicating that this putative ECM molecule continues to play roles in the central nervous system after migration and proliferative events have ceased. |
| doi_str_mv | 10.1016/0006-8993(94)91540-7 |
| format | Article |
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Recently we have described the molecular cloning of SC1, a putative brain extracellular matrix glycoprotein, showing partial similarity to the ECM glycoprotein SPARC/osteonectin. We have now examined the expression of SC1 during the development of the rat cerebellum at both the protein and mRNA levels. Our results indicate that SC1 is both temporally and spatially regulated during this process. Bergmann glial cells express SC1 mRNA and the resultant protein is deposited along the length of their radial fibres during the process of granule cell migration in the developing cerebellum. SC1 mRNA and protein is also found in the adult cerebellum, concentrated in the Bergmann glial cells and their radial processes, indicating that this putative ECM molecule continues to play roles in the central nervous system after migration and proliferative events have ceased.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(94)91540-7</identifier><identifier>PMID: 8137157</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Activated-Leukocyte Cell Adhesion Molecule ; Animals ; Bergmann glia ; Biochemistry and metabolism ; Biological and medical sciences ; Cell migration ; Cell Movement ; Central nervous system ; Cerebellum - cytology ; Cerebellum - growth & development ; Cerebellum - metabolism ; Extracellular Matrix Proteins - biosynthesis ; Female ; Fundamental and applied biological sciences. Psychology ; Glycoproteins - biosynthesis ; Immunohistochemistry ; In Situ Hybridization ; Nerve Tissue Proteins - biosynthesis ; Neuroglia - metabolism ; Neurons - physiology ; Pregnancy ; Rats ; Rats, Wistar ; RNA, Messenger - biosynthesis ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 1994-01, Vol.633 (1), p.197-205</ispartof><rights>1994 Elsevier Science B.V. All rights reserved</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-99bc6dbb2fb3f85e43279dab0399eaa26435c2ba4f30c2eef7612855c221e0a63</citedby><cites>FETCH-LOGICAL-c417t-99bc6dbb2fb3f85e43279dab0399eaa26435c2ba4f30c2eef7612855c221e0a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(94)91540-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3863241$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8137157$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mendis, Duane B.</creatorcontrib><creatorcontrib>Shahin, Susan</creatorcontrib><creatorcontrib>Gurd, James W.</creatorcontrib><creatorcontrib>Brown, Ian R.</creatorcontrib><title>Developmental expression in the rat cerebellum of SC1, a putative brain extracellular matrix glycoprotein related to SPARC</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>In the nervous system, extracellular matrix (ECM) molecules have been shown to have effects on cell migration, process outgrowth and the survival of neurons. Recently we have described the molecular cloning of SC1, a putative brain extracellular matrix glycoprotein, showing partial similarity to the ECM glycoprotein SPARC/osteonectin. We have now examined the expression of SC1 during the development of the rat cerebellum at both the protein and mRNA levels. Our results indicate that SC1 is both temporally and spatially regulated during this process. Bergmann glial cells express SC1 mRNA and the resultant protein is deposited along the length of their radial fibres during the process of granule cell migration in the developing cerebellum. SC1 mRNA and protein is also found in the adult cerebellum, concentrated in the Bergmann glial cells and their radial processes, indicating that this putative ECM molecule continues to play roles in the central nervous system after migration and proliferative events have ceased.</description><subject>Activated-Leukocyte Cell Adhesion Molecule</subject><subject>Animals</subject><subject>Bergmann glia</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Cell migration</subject><subject>Cell Movement</subject><subject>Central nervous system</subject><subject>Cerebellum - cytology</subject><subject>Cerebellum - growth & development</subject><subject>Cerebellum - metabolism</subject><subject>Extracellular Matrix Proteins - biosynthesis</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glycoproteins - biosynthesis</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization</subject><subject>Nerve Tissue Proteins - biosynthesis</subject><subject>Neuroglia - metabolism</subject><subject>Neurons - physiology</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVuLFDEQhYMo67j6DxTyIKJga67dnRdhmV0vsKC4-hyq09Ua6dsm6WHWX2_aGeZRn4qq-qo4nEPIU87ecMbLt4yxsqiNkS-NemW4Vqyo7pENrytRlEKx-2RzQh6SRzH-yq2Uhp2Rs5rLiutqQ35f4g77aR5wTNBT3M8BY_TTSP1I00-kARJ1GLDBvl8GOnX0ZstfU6DzkiD5HdImQGZxnwK4Feoh0AFS8Hv6o79z0xymhJkI2EPClqaJ3ny5-Lp9TB500Ed8cqzn5Pv7q2_bj8X15w-fthfXhVO8SoUxjSvbphFdI7tao5KiMi00TBqDAKJUUjvRgOokcwKxq0ouap1ngiODUp6TF4e_WcjtgjHZwcdVKYw4LdFWpWJaa_lfkJfaaKHrDKoD6MIUY8DOzsEPEO4sZ3bNxq7G29V4a5T9m42t8tmz4_-lGbA9HR3DyPvnxz1EB30XYHQ-njBZl1IonrF3BwyzaTuPwUbncXTY-oAu2Xby_9bxB4Bhq7o</recordid><startdate>19940107</startdate><enddate>19940107</enddate><creator>Mendis, Duane B.</creator><creator>Shahin, Susan</creator><creator>Gurd, James W.</creator><creator>Brown, Ian R.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19940107</creationdate><title>Developmental expression in the rat cerebellum of SC1, a putative brain extracellular matrix glycoprotein related to SPARC</title><author>Mendis, Duane B. ; Shahin, Susan ; Gurd, James W. ; Brown, Ian R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-99bc6dbb2fb3f85e43279dab0399eaa26435c2ba4f30c2eef7612855c221e0a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Activated-Leukocyte Cell Adhesion Molecule</topic><topic>Animals</topic><topic>Bergmann glia</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Cell migration</topic><topic>Cell Movement</topic><topic>Central nervous system</topic><topic>Cerebellum - cytology</topic><topic>Cerebellum - growth & development</topic><topic>Cerebellum - metabolism</topic><topic>Extracellular Matrix Proteins - biosynthesis</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glycoproteins - biosynthesis</topic><topic>Immunohistochemistry</topic><topic>In Situ Hybridization</topic><topic>Nerve Tissue Proteins - biosynthesis</topic><topic>Neuroglia - metabolism</topic><topic>Neurons - physiology</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mendis, Duane B.</creatorcontrib><creatorcontrib>Shahin, Susan</creatorcontrib><creatorcontrib>Gurd, James W.</creatorcontrib><creatorcontrib>Brown, Ian R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mendis, Duane B.</au><au>Shahin, Susan</au><au>Gurd, James W.</au><au>Brown, Ian R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Developmental expression in the rat cerebellum of SC1, a putative brain extracellular matrix glycoprotein related to SPARC</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1994-01-07</date><risdate>1994</risdate><volume>633</volume><issue>1</issue><spage>197</spage><epage>205</epage><pages>197-205</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>In the nervous system, extracellular matrix (ECM) molecules have been shown to have effects on cell migration, process outgrowth and the survival of neurons. Recently we have described the molecular cloning of SC1, a putative brain extracellular matrix glycoprotein, showing partial similarity to the ECM glycoprotein SPARC/osteonectin. We have now examined the expression of SC1 during the development of the rat cerebellum at both the protein and mRNA levels. Our results indicate that SC1 is both temporally and spatially regulated during this process. Bergmann glial cells express SC1 mRNA and the resultant protein is deposited along the length of their radial fibres during the process of granule cell migration in the developing cerebellum. SC1 mRNA and protein is also found in the adult cerebellum, concentrated in the Bergmann glial cells and their radial processes, indicating that this putative ECM molecule continues to play roles in the central nervous system after migration and proliferative events have ceased.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>8137157</pmid><doi>10.1016/0006-8993(94)91540-7</doi><tpages>9</tpages></addata></record> |
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| subjects | Activated-Leukocyte Cell Adhesion Molecule Animals Bergmann glia Biochemistry and metabolism Biological and medical sciences Cell migration Cell Movement Central nervous system Cerebellum - cytology Cerebellum - growth & development Cerebellum - metabolism Extracellular Matrix Proteins - biosynthesis Female Fundamental and applied biological sciences. Psychology Glycoproteins - biosynthesis Immunohistochemistry In Situ Hybridization Nerve Tissue Proteins - biosynthesis Neuroglia - metabolism Neurons - physiology Pregnancy Rats Rats, Wistar RNA, Messenger - biosynthesis Vertebrates: nervous system and sense organs |
| title | Developmental expression in the rat cerebellum of SC1, a putative brain extracellular matrix glycoprotein related to SPARC |
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