Spontaneous and aggregated IgG induced rheumatoid factor producing cells in rheumatoid arthritis
Seropositive rheumatoid arthritis (RA) patients were found to have high numbers of spontaneously occurring cells making rheumatoid factor (RF) reactive with human IgG as measured by a RF plaque forming cell (RF-PFC) assay. There was a significant positive correlation between the number of RF-PFC and...
Gespeichert in:
| Veröffentlicht in: | Rheumatology international 1985-01, Vol.5 (4), p.155-161 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 161 |
|---|---|
| container_issue | 4 |
| container_start_page | 155 |
| container_title | Rheumatology international |
| container_volume | 5 |
| creator | Pisko, E J Turner, R A Panetti, M Foster, S L Heise, E |
| description | Seropositive rheumatoid arthritis (RA) patients were found to have high numbers of spontaneously occurring cells making rheumatoid factor (RF) reactive with human IgG as measured by a RF plaque forming cell (RF-PFC) assay. There was a significant positive correlation between the number of RF-PFC and both disease activity measured by the sedimentation rate and RF titer measured by the RA latex test. Aggregated IgG and pokeweed mitogen were equally effective stimulators of RF-PFC in cultures of RA peripheral blood mononuclear leukocytes. The rheumatoid ratio of helper (T4): suppressor (T8) T lymphocytes was also significantly increased over the ratio of normal controls, but this ratio did not correlate with the number of RF-PFC. Aggregated IgG or immune complexes may be responsible for stimulating RA RF-PFC in vivo. |
| doi_str_mv | 10.1007/BF00541516 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76405249</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>76405249</sourcerecordid><originalsourceid>FETCH-LOGICAL-c282t-f963a834b8ae62aae0d3b4395e0329443806303dae03176e29a59453fbc2f9d33</originalsourceid><addsrcrecordid>eNpNkDtPwzAUhS0EKqWwsCN5YkAKXD_ixCNUtFSqxABIbMGJndSoSYrtDPx7XDUClvvQ-XR17kHoksAtAcjuHhYAKScpEUdoSjjLEiLg_RhNgWQ0yWM5RWfef0LchYAJmlDJSCb5FH287PouqM70g8eq01g1jTONCkbjVbPEttNDFWe3MUOrQm81rlUVeod3ro-S7Rpcme3WR_I_pFzYOBusP0cntdp6czH2GXpbPL7On5L183I1v18nFc1pSGopmMoZL3NlBFXKgGYlZzI1wKjknOUgGDAdhehcGCpVKnnK6rKitdSMzdD14W709TUYH4rW-r2zw29FJjiklMsI3hzAyvXeO1MXO2db5b4LAsU-zuIvzghfjVeHsjX6Fx3zYz_xDm_2</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76405249</pqid></control><display><type>article</type><title>Spontaneous and aggregated IgG induced rheumatoid factor producing cells in rheumatoid arthritis</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Pisko, E J ; Turner, R A ; Panetti, M ; Foster, S L ; Heise, E</creator><creatorcontrib>Pisko, E J ; Turner, R A ; Panetti, M ; Foster, S L ; Heise, E</creatorcontrib><description>Seropositive rheumatoid arthritis (RA) patients were found to have high numbers of spontaneously occurring cells making rheumatoid factor (RF) reactive with human IgG as measured by a RF plaque forming cell (RF-PFC) assay. There was a significant positive correlation between the number of RF-PFC and both disease activity measured by the sedimentation rate and RF titer measured by the RA latex test. Aggregated IgG and pokeweed mitogen were equally effective stimulators of RF-PFC in cultures of RA peripheral blood mononuclear leukocytes. The rheumatoid ratio of helper (T4): suppressor (T8) T lymphocytes was also significantly increased over the ratio of normal controls, but this ratio did not correlate with the number of RF-PFC. Aggregated IgG or immune complexes may be responsible for stimulating RA RF-PFC in vivo.</description><identifier>ISSN: 0172-8172</identifier><identifier>EISSN: 1437-160X</identifier><identifier>DOI: 10.1007/BF00541516</identifier><identifier>PMID: 2931794</identifier><language>eng</language><publisher>Germany</publisher><subject>Adult ; Antibody-Producing Cells - immunology ; Antigens, Differentiation, T-Lymphocyte ; Antigens, Surface - analysis ; Arthritis, Rheumatoid - immunology ; Humans ; Immunoglobulin G - immunology ; Leukocyte Count ; Macromolecular Substances ; Pokeweed Mitogens ; Rheumatoid Factor - biosynthesis ; T-Lymphocytes - classification ; T-Lymphocytes - immunology ; T-Lymphocytes, Helper-Inducer - immunology ; T-Lymphocytes, Regulatory - immunology</subject><ispartof>Rheumatology international, 1985-01, Vol.5 (4), p.155-161</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c282t-f963a834b8ae62aae0d3b4395e0329443806303dae03176e29a59453fbc2f9d33</citedby><cites>FETCH-LOGICAL-c282t-f963a834b8ae62aae0d3b4395e0329443806303dae03176e29a59453fbc2f9d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2931794$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pisko, E J</creatorcontrib><creatorcontrib>Turner, R A</creatorcontrib><creatorcontrib>Panetti, M</creatorcontrib><creatorcontrib>Foster, S L</creatorcontrib><creatorcontrib>Heise, E</creatorcontrib><title>Spontaneous and aggregated IgG induced rheumatoid factor producing cells in rheumatoid arthritis</title><title>Rheumatology international</title><addtitle>Rheumatol Int</addtitle><description>Seropositive rheumatoid arthritis (RA) patients were found to have high numbers of spontaneously occurring cells making rheumatoid factor (RF) reactive with human IgG as measured by a RF plaque forming cell (RF-PFC) assay. There was a significant positive correlation between the number of RF-PFC and both disease activity measured by the sedimentation rate and RF titer measured by the RA latex test. Aggregated IgG and pokeweed mitogen were equally effective stimulators of RF-PFC in cultures of RA peripheral blood mononuclear leukocytes. The rheumatoid ratio of helper (T4): suppressor (T8) T lymphocytes was also significantly increased over the ratio of normal controls, but this ratio did not correlate with the number of RF-PFC. Aggregated IgG or immune complexes may be responsible for stimulating RA RF-PFC in vivo.</description><subject>Adult</subject><subject>Antibody-Producing Cells - immunology</subject><subject>Antigens, Differentiation, T-Lymphocyte</subject><subject>Antigens, Surface - analysis</subject><subject>Arthritis, Rheumatoid - immunology</subject><subject>Humans</subject><subject>Immunoglobulin G - immunology</subject><subject>Leukocyte Count</subject><subject>Macromolecular Substances</subject><subject>Pokeweed Mitogens</subject><subject>Rheumatoid Factor - biosynthesis</subject><subject>T-Lymphocytes - classification</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes, Helper-Inducer - immunology</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><issn>0172-8172</issn><issn>1437-160X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkDtPwzAUhS0EKqWwsCN5YkAKXD_ixCNUtFSqxABIbMGJndSoSYrtDPx7XDUClvvQ-XR17kHoksAtAcjuHhYAKScpEUdoSjjLEiLg_RhNgWQ0yWM5RWfef0LchYAJmlDJSCb5FH287PouqM70g8eq01g1jTONCkbjVbPEttNDFWe3MUOrQm81rlUVeod3ro-S7Rpcme3WR_I_pFzYOBusP0cntdp6czH2GXpbPL7On5L183I1v18nFc1pSGopmMoZL3NlBFXKgGYlZzI1wKjknOUgGDAdhehcGCpVKnnK6rKitdSMzdD14W709TUYH4rW-r2zw29FJjiklMsI3hzAyvXeO1MXO2db5b4LAsU-zuIvzghfjVeHsjX6Fx3zYz_xDm_2</recordid><startdate>19850101</startdate><enddate>19850101</enddate><creator>Pisko, E J</creator><creator>Turner, R A</creator><creator>Panetti, M</creator><creator>Foster, S L</creator><creator>Heise, E</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19850101</creationdate><title>Spontaneous and aggregated IgG induced rheumatoid factor producing cells in rheumatoid arthritis</title><author>Pisko, E J ; Turner, R A ; Panetti, M ; Foster, S L ; Heise, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c282t-f963a834b8ae62aae0d3b4395e0329443806303dae03176e29a59453fbc2f9d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adult</topic><topic>Antibody-Producing Cells - immunology</topic><topic>Antigens, Differentiation, T-Lymphocyte</topic><topic>Antigens, Surface - analysis</topic><topic>Arthritis, Rheumatoid - immunology</topic><topic>Humans</topic><topic>Immunoglobulin G - immunology</topic><topic>Leukocyte Count</topic><topic>Macromolecular Substances</topic><topic>Pokeweed Mitogens</topic><topic>Rheumatoid Factor - biosynthesis</topic><topic>T-Lymphocytes - classification</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes, Helper-Inducer - immunology</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pisko, E J</creatorcontrib><creatorcontrib>Turner, R A</creatorcontrib><creatorcontrib>Panetti, M</creatorcontrib><creatorcontrib>Foster, S L</creatorcontrib><creatorcontrib>Heise, E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Rheumatology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pisko, E J</au><au>Turner, R A</au><au>Panetti, M</au><au>Foster, S L</au><au>Heise, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spontaneous and aggregated IgG induced rheumatoid factor producing cells in rheumatoid arthritis</atitle><jtitle>Rheumatology international</jtitle><addtitle>Rheumatol Int</addtitle><date>1985-01-01</date><risdate>1985</risdate><volume>5</volume><issue>4</issue><spage>155</spage><epage>161</epage><pages>155-161</pages><issn>0172-8172</issn><eissn>1437-160X</eissn><abstract>Seropositive rheumatoid arthritis (RA) patients were found to have high numbers of spontaneously occurring cells making rheumatoid factor (RF) reactive with human IgG as measured by a RF plaque forming cell (RF-PFC) assay. There was a significant positive correlation between the number of RF-PFC and both disease activity measured by the sedimentation rate and RF titer measured by the RA latex test. Aggregated IgG and pokeweed mitogen were equally effective stimulators of RF-PFC in cultures of RA peripheral blood mononuclear leukocytes. The rheumatoid ratio of helper (T4): suppressor (T8) T lymphocytes was also significantly increased over the ratio of normal controls, but this ratio did not correlate with the number of RF-PFC. Aggregated IgG or immune complexes may be responsible for stimulating RA RF-PFC in vivo.</abstract><cop>Germany</cop><pmid>2931794</pmid><doi>10.1007/BF00541516</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0172-8172 |
| ispartof | Rheumatology international, 1985-01, Vol.5 (4), p.155-161 |
| issn | 0172-8172 1437-160X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76405249 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Antibody-Producing Cells - immunology Antigens, Differentiation, T-Lymphocyte Antigens, Surface - analysis Arthritis, Rheumatoid - immunology Humans Immunoglobulin G - immunology Leukocyte Count Macromolecular Substances Pokeweed Mitogens Rheumatoid Factor - biosynthesis T-Lymphocytes - classification T-Lymphocytes - immunology T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Regulatory - immunology |
| title | Spontaneous and aggregated IgG induced rheumatoid factor producing cells in rheumatoid arthritis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T15%3A52%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Spontaneous%20and%20aggregated%20IgG%20induced%20rheumatoid%20factor%20producing%20cells%20in%20rheumatoid%20arthritis&rft.jtitle=Rheumatology%20international&rft.au=Pisko,%20E%20J&rft.date=1985-01-01&rft.volume=5&rft.issue=4&rft.spage=155&rft.epage=161&rft.pages=155-161&rft.issn=0172-8172&rft.eissn=1437-160X&rft_id=info:doi/10.1007/BF00541516&rft_dat=%3Cproquest_cross%3E76405249%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76405249&rft_id=info:pmid/2931794&rfr_iscdi=true |