Somatostatin and intestinal calcium transport in the rat
In intact rats we studied the influence of low doses of intravenously (i.v.) administered somatostatin (SRIF) on the net absorption and the bidirectional fluxes (lumen-to-plasma, LP; plasma-to-lumen, PL) of calcium in the duodenum, jejunum, ileum and caecum. In the duodenum SRIF inhibited the LP-flu...
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| Veröffentlicht in: | Regulatory peptides 1985-08, Vol.11 (4), p.299-308 |
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| creator | Rümenapf, G. Hessdörfer, E. Schwille, P.O. |
| description | In intact rats we studied the influence of low doses of intravenously (i.v.) administered somatostatin (SRIF) on the net absorption and the bidirectional fluxes (lumen-to-plasma, LP; plasma-to-lumen, PL) of calcium in the duodenum, jejunum, ileum and caecum. In the duodenum SRIF inhibited the LP-flux and the net absorption of Ca significantly at infusion rates of 0.75 and 1.0 μg SRIF·kg
−1·h
−1. The PL-flux was not altered by any of the SRIF doses administered. In the other gut segments studied (jejunum, ileum, caecum) neither the net absorption nor the bidirectional Ca fluxes were changed by i.v. SRIF. It is concluded that (1) SRIF in the plasma levels achieved in this study has an influence on the duodenal calcium absorption (CaA) of the rat; (2) questions regarding the mechanisms of this action as well as the physiological significance of our findings are as yet unresolved. |
| doi_str_mv | 10.1016/0167-0115(85)90202-2 |
| format | Article |
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−1·h
−1. The PL-flux was not altered by any of the SRIF doses administered. In the other gut segments studied (jejunum, ileum, caecum) neither the net absorption nor the bidirectional Ca fluxes were changed by i.v. SRIF. It is concluded that (1) SRIF in the plasma levels achieved in this study has an influence on the duodenal calcium absorption (CaA) of the rat; (2) questions regarding the mechanisms of this action as well as the physiological significance of our findings are as yet unresolved.</description><identifier>ISSN: 0167-0115</identifier><identifier>EISSN: 1873-1686</identifier><identifier>DOI: 10.1016/0167-0115(85)90202-2</identifier><identifier>PMID: 2864719</identifier><identifier>CODEN: REPPDY</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Calcium - metabolism ; Cecum - drug effects ; Cecum - metabolism ; Duodenum - metabolism ; Fundamental and applied biological sciences. Psychology ; Gastrointestinal hormones ; Ileum - metabolism ; Intestinal Absorption - drug effects ; intestinal calcium absorption ; Intestine, Small - drug effects ; Intestine, Small - metabolism ; Jejunum - metabolism ; Kinetics ; Male ; Organ Specificity ; rat ; Rats ; Rats, Inbred Strains ; somatostatin ; Somatostatin - pharmacology ; Vertebrates: digestive system</subject><ispartof>Regulatory peptides, 1985-08, Vol.11 (4), p.299-308</ispartof><rights>1985</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-98aa7296e354190135c99d1e84ef8ebaa8b7bfbb36f3dca3b1fa8cc84a8a601a3</citedby><cites>FETCH-LOGICAL-c386t-98aa7296e354190135c99d1e84ef8ebaa8b7bfbb36f3dca3b1fa8cc84a8a601a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0167011585902022$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8621939$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2864719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rümenapf, G.</creatorcontrib><creatorcontrib>Hessdörfer, E.</creatorcontrib><creatorcontrib>Schwille, P.O.</creatorcontrib><title>Somatostatin and intestinal calcium transport in the rat</title><title>Regulatory peptides</title><addtitle>Regul Pept</addtitle><description>In intact rats we studied the influence of low doses of intravenously (i.v.) administered somatostatin (SRIF) on the net absorption and the bidirectional fluxes (lumen-to-plasma, LP; plasma-to-lumen, PL) of calcium in the duodenum, jejunum, ileum and caecum. In the duodenum SRIF inhibited the LP-flux and the net absorption of Ca significantly at infusion rates of 0.75 and 1.0 μg SRIF·kg
−1·h
−1. The PL-flux was not altered by any of the SRIF doses administered. In the other gut segments studied (jejunum, ileum, caecum) neither the net absorption nor the bidirectional Ca fluxes were changed by i.v. SRIF. It is concluded that (1) SRIF in the plasma levels achieved in this study has an influence on the duodenal calcium absorption (CaA) of the rat; (2) questions regarding the mechanisms of this action as well as the physiological significance of our findings are as yet unresolved.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calcium - metabolism</subject><subject>Cecum - drug effects</subject><subject>Cecum - metabolism</subject><subject>Duodenum - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastrointestinal hormones</subject><subject>Ileum - metabolism</subject><subject>Intestinal Absorption - drug effects</subject><subject>intestinal calcium absorption</subject><subject>Intestine, Small - drug effects</subject><subject>Intestine, Small - metabolism</subject><subject>Jejunum - metabolism</subject><subject>Kinetics</subject><subject>Male</subject><subject>Organ Specificity</subject><subject>rat</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>somatostatin</subject><subject>Somatostatin - pharmacology</subject><subject>Vertebrates: digestive system</subject><issn>0167-0115</issn><issn>1873-1686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo67r6DxR6ENFDNWnaJL0IsvgFCx7Uc5imU4z0Y01SwX9v6i579DAMw_vMMDyEnDJ6zSgTN7FkShkrLlVxVdKMZmm2R-ZMSZ4yocQ-me-QQ3Lk_SelrJCSz8gsUyKXrJwT9Tp0EAYfINg-gb5ObB_QxwHaxEBr7NglwUHv14MLMUzCByYOwjE5aKD1eLLtC_L-cP-2fEpXL4_Py7tVargSIS0VgMxKgbzIWUkZL0xZ1gxVjo3CCkBVsmqqiouG1wZ4xRpQxqgcFAjKgC_Ixebu2g1fY_xMd9YbbFvocRi9liKneVHICOYb0LjBe4eNXjvbgfvRjOpJmJ5s6MmGVoX-E6azuHa2vT9WHda7pa2hmJ9vc_DRRxNVGOt3mBJZhCbsdoNhdPFt0WlvLPYGa-vQBF0P9v8_fgEM3Ybg</recordid><startdate>198508</startdate><enddate>198508</enddate><creator>Rümenapf, G.</creator><creator>Hessdörfer, E.</creator><creator>Schwille, P.O.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198508</creationdate><title>Somatostatin and intestinal calcium transport in the rat</title><author>Rümenapf, G. ; Hessdörfer, E. ; Schwille, P.O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-98aa7296e354190135c99d1e84ef8ebaa8b7bfbb36f3dca3b1fa8cc84a8a601a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Calcium - metabolism</topic><topic>Cecum - drug effects</topic><topic>Cecum - metabolism</topic><topic>Duodenum - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastrointestinal hormones</topic><topic>Ileum - metabolism</topic><topic>Intestinal Absorption - drug effects</topic><topic>intestinal calcium absorption</topic><topic>Intestine, Small - drug effects</topic><topic>Intestine, Small - metabolism</topic><topic>Jejunum - metabolism</topic><topic>Kinetics</topic><topic>Male</topic><topic>Organ Specificity</topic><topic>rat</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>somatostatin</topic><topic>Somatostatin - pharmacology</topic><topic>Vertebrates: digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rümenapf, G.</creatorcontrib><creatorcontrib>Hessdörfer, E.</creatorcontrib><creatorcontrib>Schwille, P.O.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Regulatory peptides</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rümenapf, G.</au><au>Hessdörfer, E.</au><au>Schwille, P.O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Somatostatin and intestinal calcium transport in the rat</atitle><jtitle>Regulatory peptides</jtitle><addtitle>Regul Pept</addtitle><date>1985-08</date><risdate>1985</risdate><volume>11</volume><issue>4</issue><spage>299</spage><epage>308</epage><pages>299-308</pages><issn>0167-0115</issn><eissn>1873-1686</eissn><coden>REPPDY</coden><abstract>In intact rats we studied the influence of low doses of intravenously (i.v.) administered somatostatin (SRIF) on the net absorption and the bidirectional fluxes (lumen-to-plasma, LP; plasma-to-lumen, PL) of calcium in the duodenum, jejunum, ileum and caecum. In the duodenum SRIF inhibited the LP-flux and the net absorption of Ca significantly at infusion rates of 0.75 and 1.0 μg SRIF·kg
−1·h
−1. The PL-flux was not altered by any of the SRIF doses administered. In the other gut segments studied (jejunum, ileum, caecum) neither the net absorption nor the bidirectional Ca fluxes were changed by i.v. SRIF. It is concluded that (1) SRIF in the plasma levels achieved in this study has an influence on the duodenal calcium absorption (CaA) of the rat; (2) questions regarding the mechanisms of this action as well as the physiological significance of our findings are as yet unresolved.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2864719</pmid><doi>10.1016/0167-0115(85)90202-2</doi><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 0167-0115 |
| ispartof | Regulatory peptides, 1985-08, Vol.11 (4), p.299-308 |
| issn | 0167-0115 1873-1686 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Biological and medical sciences Calcium - metabolism Cecum - drug effects Cecum - metabolism Duodenum - metabolism Fundamental and applied biological sciences. Psychology Gastrointestinal hormones Ileum - metabolism Intestinal Absorption - drug effects intestinal calcium absorption Intestine, Small - drug effects Intestine, Small - metabolism Jejunum - metabolism Kinetics Male Organ Specificity rat Rats Rats, Inbred Strains somatostatin Somatostatin - pharmacology Vertebrates: digestive system |
| title | Somatostatin and intestinal calcium transport in the rat |
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