The Effect of Isoflurane or Spinal Anesthesia on Indocyanine Green Disappearance Rate in the Elderly
This study was designed to measure the disappearance rate of indocyanine green (ICG) as an indicator of hepatic blood flow in elderly patients undergoing internal fixation of fractured neck of femur. All patients were aged 60–90 yr and were randomized to receive either spinal (n = 10) or isoflurane...
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| Veröffentlicht in: | Anesthesia and analgesia 1994-04, Vol.78 (4), p.706-709 |
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| container_title | Anesthesia and analgesia |
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| creator | Darling, John R. Murray, James M. Hainsworth, A. Moira Trinick, Thomas R. |
| description | This study was designed to measure the disappearance rate of indocyanine green (ICG) as an indicator of hepatic blood flow in elderly patients undergoing internal fixation of fractured neck of femur. All patients were aged 60–90 yr and were randomized to receive either spinal (n = 10) or isoflurane (n = 10) anesthesia. In both groups systolic arterial blood pressure was maintained within 15% of resting levels by administration of fluids intravenously without vasoactive drugs. Patients were excluded if they required vasopressors to maintain arterial blood pressure. ICG disappearance rate was calculated using a single bolus technique before induction of anesthesia, and at 30, 60, and 120 min after induction of anesthesia. Sixteen patients completed the study. There were no statistically significant changes in ICG disappearance rate in either group at any time during the study, indicating that hepatic blood flow is not significantly altered by either spinal or isoflurane anesthesia provided that arterial blood pressure is maintained. |
| doi_str_mv | 10.1213/00000539-199404000-00016 |
| format | Article |
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There were no statistically significant changes in ICG disappearance rate in either group at any time during the study, indicating that hepatic blood flow is not significantly altered by either spinal or isoflurane anesthesia provided that arterial blood pressure is maintained.</description><identifier>ISSN: 0003-2999</identifier><identifier>EISSN: 1526-7598</identifier><identifier>DOI: 10.1213/00000539-199404000-00016</identifier><identifier>PMID: 8135390</identifier><identifier>CODEN: AACRAT</identifier><language>eng</language><publisher>Hagerstown, MD: International Anesthesia Research Society</publisher><subject>Aged ; Aged, 80 and over ; Anesthesia ; Anesthesia, Inhalation ; Anesthesia, Spinal ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Femoral Neck Fractures - surgery ; General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation ; Humans ; Indocyanine Green ; Isoflurane ; Liver Circulation - physiology ; Medical sciences ; Middle Aged</subject><ispartof>Anesthesia and analgesia, 1994-04, Vol.78 (4), p.706-709</ispartof><rights>1994 International Anesthesia Research Society</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3846-b3e279ed1c74b2c5f5536a954d3b8cee82aaff283078a1a1bd2cca67397aad873</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00000539-199404000-00016$$EHTML$$P50$$Gwolterskluwer$$H</linktohtml><link.rule.ids>314,776,780,4595,27901,27902,65206</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4226243$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8135390$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Darling, John R.</creatorcontrib><creatorcontrib>Murray, James M.</creatorcontrib><creatorcontrib>Hainsworth, A. Moira</creatorcontrib><creatorcontrib>Trinick, Thomas R.</creatorcontrib><title>The Effect of Isoflurane or Spinal Anesthesia on Indocyanine Green Disappearance Rate in the Elderly</title><title>Anesthesia and analgesia</title><addtitle>Anesth Analg</addtitle><description>This study was designed to measure the disappearance rate of indocyanine green (ICG) as an indicator of hepatic blood flow in elderly patients undergoing internal fixation of fractured neck of femur. All patients were aged 60–90 yr and were randomized to receive either spinal (n = 10) or isoflurane (n = 10) anesthesia. In both groups systolic arterial blood pressure was maintained within 15% of resting levels by administration of fluids intravenously without vasoactive drugs. Patients were excluded if they required vasopressors to maintain arterial blood pressure. ICG disappearance rate was calculated using a single bolus technique before induction of anesthesia, and at 30, 60, and 120 min after induction of anesthesia. Sixteen patients completed the study. There were no statistically significant changes in ICG disappearance rate in either group at any time during the study, indicating that hepatic blood flow is not significantly altered by either spinal or isoflurane anesthesia provided that arterial blood pressure is maintained.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anesthesia</subject><subject>Anesthesia, Inhalation</subject><subject>Anesthesia, Spinal</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Femoral Neck Fractures - surgery</subject><subject>General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation</subject><subject>Humans</subject><subject>Indocyanine Green</subject><subject>Isoflurane</subject><subject>Liver Circulation - physiology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><issn>0003-2999</issn><issn>1526-7598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kd9v2yAQgNG0Kku7_QmTeJj25taAf8BjlKVtpEiVuu4ZnfGheCPGA1tV_vviJsvbkBCC--44PgihLL9lnIm7fB6lUBlTqsiLtMnSZNUHsmQlr7K6VPIjWaYzkXGl1CdyHePvGclltSALyUTKzpekfdkj3ViLZqTe0m301k0BeqQ-0J9D14Ojqx7juMfYAfU93fatN0fou8Q8BMSe_ugiDANCSjNIn2FE2vV0nAu7FoM7fiZXFlzEL-f1hvy637ysH7Pd08N2vdplRsiiyhqBvFbYMlMXDTelLUtRgSqLVjTSIEoOYC2XIq8lMGBNy42BqhaqBmhlLW7I91PdIfi_U2paH7po0Ln0Hj9FXVezK14kUJ5AE3yMAa0eQneAcNQs17Ng_U-wvgjW74JT6tfzHVNzwPaSeDaa4t_OcYgGnJ2ldPGCFZxXqYGEFSfs1bsRQ_zjplcMeo_gxr3-3_eKN_YOkmE</recordid><startdate>199404</startdate><enddate>199404</enddate><creator>Darling, John R.</creator><creator>Murray, James M.</creator><creator>Hainsworth, A. 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Moira ; Trinick, Thomas R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3846-b3e279ed1c74b2c5f5536a954d3b8cee82aaff283078a1a1bd2cca67397aad873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anesthesia</topic><topic>Anesthesia, Inhalation</topic><topic>Anesthesia, Spinal</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Femoral Neck Fractures - surgery</topic><topic>General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation</topic><topic>Humans</topic><topic>Indocyanine Green</topic><topic>Isoflurane</topic><topic>Liver Circulation - physiology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Darling, John R.</creatorcontrib><creatorcontrib>Murray, James M.</creatorcontrib><creatorcontrib>Hainsworth, A. 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Moira</au><au>Trinick, Thomas R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Isoflurane or Spinal Anesthesia on Indocyanine Green Disappearance Rate in the Elderly</atitle><jtitle>Anesthesia and analgesia</jtitle><addtitle>Anesth Analg</addtitle><date>1994-04</date><risdate>1994</risdate><volume>78</volume><issue>4</issue><spage>706</spage><epage>709</epage><pages>706-709</pages><issn>0003-2999</issn><eissn>1526-7598</eissn><coden>AACRAT</coden><abstract>This study was designed to measure the disappearance rate of indocyanine green (ICG) as an indicator of hepatic blood flow in elderly patients undergoing internal fixation of fractured neck of femur. All patients were aged 60–90 yr and were randomized to receive either spinal (n = 10) or isoflurane (n = 10) anesthesia. In both groups systolic arterial blood pressure was maintained within 15% of resting levels by administration of fluids intravenously without vasoactive drugs. Patients were excluded if they required vasopressors to maintain arterial blood pressure. ICG disappearance rate was calculated using a single bolus technique before induction of anesthesia, and at 30, 60, and 120 min after induction of anesthesia. Sixteen patients completed the study. There were no statistically significant changes in ICG disappearance rate in either group at any time during the study, indicating that hepatic blood flow is not significantly altered by either spinal or isoflurane anesthesia provided that arterial blood pressure is maintained.</abstract><cop>Hagerstown, MD</cop><pub>International Anesthesia Research Society</pub><pmid>8135390</pmid><doi>10.1213/00000539-199404000-00016</doi><tpages>4</tpages></addata></record> |
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| ispartof | Anesthesia and analgesia, 1994-04, Vol.78 (4), p.706-709 |
| issn | 0003-2999 1526-7598 |
| language | eng |
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| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Aged Aged, 80 and over Anesthesia Anesthesia, Inhalation Anesthesia, Spinal Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Femoral Neck Fractures - surgery General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation Humans Indocyanine Green Isoflurane Liver Circulation - physiology Medical sciences Middle Aged |
| title | The Effect of Isoflurane or Spinal Anesthesia on Indocyanine Green Disappearance Rate in the Elderly |
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