Transdermal fentanyl as treatment for chronic low back pain
Management of chronic low back pain often includes oral opioid use. The effectiveness of therapy is dependent upon compliance, which in turn is dependent upon response, side effects, access, and convenience. Our hypothesis was that a transdermal fentanyl system would provide more effective pain mana...
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| Veröffentlicht in: | Journal of pain and symptom management 1997-10, Vol.14 (4), p.218-224 |
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| container_issue | 4 |
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| container_title | Journal of pain and symptom management |
| container_volume | 14 |
| creator | Simpson, Richard K. Edmondson, Everton A. Constant, Charles F. Collier, Connie |
| description | Management of chronic low back pain often includes oral opioid use. The effectiveness of therapy is dependent upon compliance, which in turn is dependent upon response, side effects, access, and convenience. Our hypothesis was that a transdermal fentanyl system would provide more effective pain management than oral opioids. Fifty patients with chronic low back pain were examined. After titration to levels corresponding to current oral opioid use, each patient was maintained on transdermal fentanyl for one monht. Oral opioid therapy was then resumed. Their experience was assessed with the visual analogue scale for pain intensity, a numerical pain score, the Oswestry disability questionnaire, the pain disability index, and the Verran Snyder-Halpern sleep scale. Significant improvement in pain relief and disability was found with transdermal fentanyl compared with oral opioids. Mild opioid side effects were common, but easily controlled. Use of transdermal fentanyl is an effective alternative to oral opioids for managing chronic low back pain. |
| doi_str_mv | 10.1016/S0885-3924(97)00183-8 |
| format | Article |
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The effectiveness of therapy is dependent upon compliance, which in turn is dependent upon response, side effects, access, and convenience. Our hypothesis was that a transdermal fentanyl system would provide more effective pain management than oral opioids. Fifty patients with chronic low back pain were examined. After titration to levels corresponding to current oral opioid use, each patient was maintained on transdermal fentanyl for one monht. Oral opioid therapy was then resumed. Their experience was assessed with the visual analogue scale for pain intensity, a numerical pain score, the Oswestry disability questionnaire, the pain disability index, and the Verran Snyder-Halpern sleep scale. Significant improvement in pain relief and disability was found with transdermal fentanyl compared with oral opioids. Mild opioid side effects were common, but easily controlled. 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The effectiveness of therapy is dependent upon compliance, which in turn is dependent upon response, side effects, access, and convenience. Our hypothesis was that a transdermal fentanyl system would provide more effective pain management than oral opioids. Fifty patients with chronic low back pain were examined. After titration to levels corresponding to current oral opioid use, each patient was maintained on transdermal fentanyl for one monht. Oral opioid therapy was then resumed. Their experience was assessed with the visual analogue scale for pain intensity, a numerical pain score, the Oswestry disability questionnaire, the pain disability index, and the Verran Snyder-Halpern sleep scale. Significant improvement in pain relief and disability was found with transdermal fentanyl compared with oral opioids. Mild opioid side effects were common, but easily controlled. Use of transdermal fentanyl is an effective alternative to oral opioids for managing chronic low back pain.</description><subject>Administration, Cutaneous</subject><subject>Adult</subject><subject>Aged</subject><subject>Analgesics</subject><subject>Analgesics, Opioid - adverse effects</subject><subject>Analgesics, Opioid - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>chronic low back pain</subject><subject>Female</subject><subject>Fentanyl - adverse effects</subject><subject>Fentanyl - therapeutic use</subject><subject>Humans</subject><subject>Low Back Pain - drug therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neuropharmacology</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Transcutaneous fentanyl patch</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Simpson, Richard K.</creatorcontrib><creatorcontrib>Edmondson, Everton A.</creatorcontrib><creatorcontrib>Constant, Charles F.</creatorcontrib><creatorcontrib>Collier, Connie</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><jtitle>Journal of pain and symptom management</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Simpson, Richard K.</au><au>Edmondson, Everton A.</au><au>Constant, Charles F.</au><au>Collier, Connie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transdermal fentanyl as treatment for chronic low back pain</atitle><jtitle>Journal of pain and symptom management</jtitle><addtitle>J Pain Symptom Manage</addtitle><date>1997-10-01</date><risdate>1997</risdate><volume>14</volume><issue>4</issue><spage>218</spage><epage>224</epage><pages>218-224</pages><issn>0885-3924</issn><eissn>1873-6513</eissn><abstract>Management of chronic low back pain often includes oral opioid use. The effectiveness of therapy is dependent upon compliance, which in turn is dependent upon response, side effects, access, and convenience. Our hypothesis was that a transdermal fentanyl system would provide more effective pain management than oral opioids. Fifty patients with chronic low back pain were examined. After titration to levels corresponding to current oral opioid use, each patient was maintained on transdermal fentanyl for one monht. Oral opioid therapy was then resumed. Their experience was assessed with the visual analogue scale for pain intensity, a numerical pain score, the Oswestry disability questionnaire, the pain disability index, and the Verran Snyder-Halpern sleep scale. Significant improvement in pain relief and disability was found with transdermal fentanyl compared with oral opioids. Mild opioid side effects were common, but easily controlled. 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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Administration, Cutaneous Adult Aged Analgesics Analgesics, Opioid - adverse effects Analgesics, Opioid - therapeutic use Biological and medical sciences Chronic Disease chronic low back pain Female Fentanyl - adverse effects Fentanyl - therapeutic use Humans Low Back Pain - drug therapy Male Medical sciences Middle Aged Neuropharmacology Pharmacology. Drug treatments Transcutaneous fentanyl patch |
| title | Transdermal fentanyl as treatment for chronic low back pain |
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