Little or No Expression of the Cholecystokinin-A Receptor Gene in the Pancreas of Diabetic Rats (Otsuka Long-Evans Tokushima Fatty=OLETF Rats)
Expression of the CCK-A receptor gene in the pancreas and pancreatic exocrine function was examined in diabetic model rats (OLETF) at 5 wks of age. Little or no CCK-A receptor was detected in the pancreas of OLETF rats. Pancreatic exocrine function in response to exogenous CCK and to bile-pancreatic...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1994-03, Vol.199 (2), p.482-488 |
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| creator | Funakoshi, A. Miyasaka, K. Jimi, A. Kawanai, T. Takata, Y. Kono, A. |
| description | Expression of the CCK-A receptor gene in the pancreas and pancreatic exocrine function was examined in diabetic model rats (OLETF) at 5 wks of age. Little or no CCK-A receptor was detected in the pancreas of OLETF rats. Pancreatic exocrine function in response to exogenous CCK and to bile-pancreatic juice diversion (endogenous CCK) was impaired in conscious OLETF rats. The pancreatic insulin and protein contents of OLETF (Otsuka Long-Evans Tokushima Fatty) and control LETO (Long-Evans Tokushima Otsuka) rats were not significantly different. No histological abnormalities or expression of pancreatitis associated protein (PAP) mRNA was detected in the pancreas in either group. These results suggest that OLETF rats are a new experimental model for congenital deficiency of CCK-A receptor in the pancreas. |
| doi_str_mv | 10.1006/bbrc.1994.1254 |
| format | Article |
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Little or no CCK-A receptor was detected in the pancreas of OLETF rats. Pancreatic exocrine function in response to exogenous CCK and to bile-pancreatic juice diversion (endogenous CCK) was impaired in conscious OLETF rats. The pancreatic insulin and protein contents of OLETF (Otsuka Long-Evans Tokushima Fatty) and control LETO (Long-Evans Tokushima Otsuka) rats were not significantly different. No histological abnormalities or expression of pancreatitis associated protein (PAP) mRNA was detected in the pancreas in either group. These results suggest that OLETF rats are a new experimental model for congenital deficiency of CCK-A receptor in the pancreas.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1006/bbrc.1994.1254</identifier><identifier>PMID: 8135789</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Antigens, Neoplasm ; Base Sequence ; Biomarkers, Tumor ; Blotting, Northern ; Cholecystokinin - physiology ; Cytoplasmic Granules - pathology ; Cytoplasmic Granules - ultrastructure ; DIABETE ; DIABETES ; Diabetes Mellitus, Type 2 - genetics ; Diabetes Mellitus, Type 2 - metabolism ; Diabetes Mellitus, Type 2 - physiopathology ; EXPRESION GENICA ; EXPRESSION DES GENES ; GENE ; Gene Expression ; GENES ; HORMONAS GASTROINTESTINALES ; HORMONE GASTROINTESTINALE ; Lectins, C-Type ; Male ; Microscopy, Electron ; MODELE ; MODELOS ; Molecular Sequence Data ; Oligonucleotide Probes ; PANCREAS ; Pancreas - metabolism ; Pancreas - pathology ; Pancreas - ultrastructure ; Pancreatic Juice - secretion ; Pancreatitis-Associated Proteins ; Protein Biosynthesis ; RAT ; RATA ; Rats ; Rats, Mutant Strains ; RECEPTEUR D'HORMONE ; Receptor, Cholecystokinin A ; RECEPTORES DE HORMONAS ; Receptors, Cholecystokinin - biosynthesis ; RNA, Messenger - analysis ; RNA, Messenger - biosynthesis ; Sincalide - pharmacology</subject><ispartof>Biochemical and biophysical research communications, 1994-03, Vol.199 (2), p.482-488</ispartof><rights>1994 Academic Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-ed77dd141fbd5335b864848df9357af69aba397bf45f4825b505f1f1d8a80a9d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/bbrc.1994.1254$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8135789$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Funakoshi, A.</creatorcontrib><creatorcontrib>Miyasaka, K.</creatorcontrib><creatorcontrib>Jimi, A.</creatorcontrib><creatorcontrib>Kawanai, T.</creatorcontrib><creatorcontrib>Takata, Y.</creatorcontrib><creatorcontrib>Kono, A.</creatorcontrib><title>Little or No Expression of the Cholecystokinin-A Receptor Gene in the Pancreas of Diabetic Rats (Otsuka Long-Evans Tokushima Fatty=OLETF Rats)</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Expression of the CCK-A receptor gene in the pancreas and pancreatic exocrine function was examined in diabetic model rats (OLETF) at 5 wks of age. Little or no CCK-A receptor was detected in the pancreas of OLETF rats. Pancreatic exocrine function in response to exogenous CCK and to bile-pancreatic juice diversion (endogenous CCK) was impaired in conscious OLETF rats. The pancreatic insulin and protein contents of OLETF (Otsuka Long-Evans Tokushima Fatty) and control LETO (Long-Evans Tokushima Otsuka) rats were not significantly different. No histological abnormalities or expression of pancreatitis associated protein (PAP) mRNA was detected in the pancreas in either group. These results suggest that OLETF rats are a new experimental model for congenital deficiency of CCK-A receptor in the pancreas.</description><subject>Animals</subject><subject>Antigens, Neoplasm</subject><subject>Base Sequence</subject><subject>Biomarkers, Tumor</subject><subject>Blotting, Northern</subject><subject>Cholecystokinin - physiology</subject><subject>Cytoplasmic Granules - pathology</subject><subject>Cytoplasmic Granules - ultrastructure</subject><subject>DIABETE</subject><subject>DIABETES</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>EXPRESION GENICA</subject><subject>EXPRESSION DES GENES</subject><subject>GENE</subject><subject>Gene Expression</subject><subject>GENES</subject><subject>HORMONAS GASTROINTESTINALES</subject><subject>HORMONE GASTROINTESTINALE</subject><subject>Lectins, C-Type</subject><subject>Male</subject><subject>Microscopy, Electron</subject><subject>MODELE</subject><subject>MODELOS</subject><subject>Molecular Sequence Data</subject><subject>Oligonucleotide Probes</subject><subject>PANCREAS</subject><subject>Pancreas - metabolism</subject><subject>Pancreas - pathology</subject><subject>Pancreas - ultrastructure</subject><subject>Pancreatic Juice - secretion</subject><subject>Pancreatitis-Associated Proteins</subject><subject>Protein Biosynthesis</subject><subject>RAT</subject><subject>RATA</subject><subject>Rats</subject><subject>Rats, Mutant Strains</subject><subject>RECEPTEUR D'HORMONE</subject><subject>Receptor, Cholecystokinin A</subject><subject>RECEPTORES DE HORMONAS</subject><subject>Receptors, Cholecystokinin - biosynthesis</subject><subject>RNA, Messenger - analysis</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Sincalide - pharmacology</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcGO0zAQhiMEWsrClQMSkk8IDil2Yif2gcOqtAtSRNHSlbhZjjPemqZ2sZ0VfQmemWRbcUOc5vB_M6OZL8teEjwnGFfv2zboORGCzknB6KNsRrDAeUEwfZzN8EjkhSDfn2bPYvyBMSG0EhfZBSclq7mYZb8bm1IPyAf0xaPlr0OAGK13yBuUtoAWW9-DPsbkd9ZZl1-hG9BwSCN_DQ6QdQ_YV-V0ABWnto9WtZCsRjcqRfR2neKwU6jx7i5f3isX0cbvhri1e4VWKqXjh3Wz3Kwe6HfPsydG9RFenOtldrtabhaf8mZ9_Xlx1eS65CLl0NV11xFKTNuxsmQtryinvDNiPEuZSqhWlaJuDWWG8oK1DDNDDOm44liJrrzM3pzmHoL_OUBMcm-jhr5XDvwQZV1RXBSs-C9IKl6KoqhGcH4CdfAxBjDyEMYTw1ESLCdTcjIlJ1NyMjU2vD5PHto9dH_xs5oxf3XKjfJS3QUb5e03QVlBBR5DfgphfNK9hSCjtuA0dDaATrLz9l97_wA9N6qt</recordid><startdate>19940315</startdate><enddate>19940315</enddate><creator>Funakoshi, A.</creator><creator>Miyasaka, K.</creator><creator>Jimi, A.</creator><creator>Kawanai, T.</creator><creator>Takata, Y.</creator><creator>Kono, A.</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>19940315</creationdate><title>Little or No Expression of the Cholecystokinin-A Receptor Gene in the Pancreas of Diabetic Rats (Otsuka Long-Evans Tokushima Fatty=OLETF Rats)</title><author>Funakoshi, A. ; Miyasaka, K. ; Jimi, A. ; Kawanai, T. ; Takata, Y. ; Kono, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-ed77dd141fbd5335b864848df9357af69aba397bf45f4825b505f1f1d8a80a9d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Antigens, Neoplasm</topic><topic>Base Sequence</topic><topic>Biomarkers, Tumor</topic><topic>Blotting, Northern</topic><topic>Cholecystokinin - physiology</topic><topic>Cytoplasmic Granules - pathology</topic><topic>Cytoplasmic Granules - ultrastructure</topic><topic>DIABETE</topic><topic>DIABETES</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>EXPRESION GENICA</topic><topic>EXPRESSION DES GENES</topic><topic>GENE</topic><topic>Gene Expression</topic><topic>GENES</topic><topic>HORMONAS GASTROINTESTINALES</topic><topic>HORMONE GASTROINTESTINALE</topic><topic>Lectins, C-Type</topic><topic>Male</topic><topic>Microscopy, Electron</topic><topic>MODELE</topic><topic>MODELOS</topic><topic>Molecular Sequence Data</topic><topic>Oligonucleotide Probes</topic><topic>PANCREAS</topic><topic>Pancreas - metabolism</topic><topic>Pancreas - pathology</topic><topic>Pancreas - ultrastructure</topic><topic>Pancreatic Juice - secretion</topic><topic>Pancreatitis-Associated Proteins</topic><topic>Protein Biosynthesis</topic><topic>RAT</topic><topic>RATA</topic><topic>Rats</topic><topic>Rats, Mutant Strains</topic><topic>RECEPTEUR D'HORMONE</topic><topic>Receptor, Cholecystokinin A</topic><topic>RECEPTORES DE HORMONAS</topic><topic>Receptors, Cholecystokinin - biosynthesis</topic><topic>RNA, Messenger - analysis</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Sincalide - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Funakoshi, A.</creatorcontrib><creatorcontrib>Miyasaka, K.</creatorcontrib><creatorcontrib>Jimi, A.</creatorcontrib><creatorcontrib>Kawanai, T.</creatorcontrib><creatorcontrib>Takata, Y.</creatorcontrib><creatorcontrib>Kono, A.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Funakoshi, A.</au><au>Miyasaka, K.</au><au>Jimi, A.</au><au>Kawanai, T.</au><au>Takata, Y.</au><au>Kono, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Little or No Expression of the Cholecystokinin-A Receptor Gene in the Pancreas of Diabetic Rats (Otsuka Long-Evans Tokushima Fatty=OLETF Rats)</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1994-03-15</date><risdate>1994</risdate><volume>199</volume><issue>2</issue><spage>482</spage><epage>488</epage><pages>482-488</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Expression of the CCK-A receptor gene in the pancreas and pancreatic exocrine function was examined in diabetic model rats (OLETF) at 5 wks of age. Little or no CCK-A receptor was detected in the pancreas of OLETF rats. Pancreatic exocrine function in response to exogenous CCK and to bile-pancreatic juice diversion (endogenous CCK) was impaired in conscious OLETF rats. The pancreatic insulin and protein contents of OLETF (Otsuka Long-Evans Tokushima Fatty) and control LETO (Long-Evans Tokushima Otsuka) rats were not significantly different. No histological abnormalities or expression of pancreatitis associated protein (PAP) mRNA was detected in the pancreas in either group. These results suggest that OLETF rats are a new experimental model for congenital deficiency of CCK-A receptor in the pancreas.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>8135789</pmid><doi>10.1006/bbrc.1994.1254</doi><tpages>7</tpages></addata></record> |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Animals Antigens, Neoplasm Base Sequence Biomarkers, Tumor Blotting, Northern Cholecystokinin - physiology Cytoplasmic Granules - pathology Cytoplasmic Granules - ultrastructure DIABETE DIABETES Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - physiopathology EXPRESION GENICA EXPRESSION DES GENES GENE Gene Expression GENES HORMONAS GASTROINTESTINALES HORMONE GASTROINTESTINALE Lectins, C-Type Male Microscopy, Electron MODELE MODELOS Molecular Sequence Data Oligonucleotide Probes PANCREAS Pancreas - metabolism Pancreas - pathology Pancreas - ultrastructure Pancreatic Juice - secretion Pancreatitis-Associated Proteins Protein Biosynthesis RAT RATA Rats Rats, Mutant Strains RECEPTEUR D'HORMONE Receptor, Cholecystokinin A RECEPTORES DE HORMONAS Receptors, Cholecystokinin - biosynthesis RNA, Messenger - analysis RNA, Messenger - biosynthesis Sincalide - pharmacology |
| title | Little or No Expression of the Cholecystokinin-A Receptor Gene in the Pancreas of Diabetic Rats (Otsuka Long-Evans Tokushima Fatty=OLETF Rats) |
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