SERUM LEVELS AND SPUTUM LEVELS OF CEFMENOXIME ON RESPIRATORY TRACT INFECTIONS
In 11 patients with respiratory tract infections, the concentrations of cefmenoxime (CMX) in serum and sputum after 1 hour intravenous administration of 2 g of CMX were investigated. The peak serum level of CMX was 102.2±11.4 μg/ml after 1 hour drip infusion, then declined and was 3.5±10.55 μg/ml af...
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| Veröffentlicht in: | Japanese journal of antibiotics 1985/06/25, Vol.38(6), pp.1638-1642 |
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| container_issue | 6 |
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| container_title | Japanese journal of antibiotics |
| container_volume | 38 |
| creator | ISHIKAWA, JUJIRO NAKATANI, SHIGERU NINOMARU, SHINYA SASAKI, TAKAO KOSHOBU, TOMOAKI MATSUMOTO, YUKIO |
| description | In 11 patients with respiratory tract infections, the concentrations of cefmenoxime (CMX) in serum and sputum after 1 hour intravenous administration of 2 g of CMX were investigated. The peak serum level of CMX was 102.2±11.4 μg/ml after 1 hour drip infusion, then declined and was 3.5±10.55 μg/ml after 5 hours. Sputum level of CMX was lower than serum level but it was able to cover enough for MIC of Haemophilus influenzae, Klebsiella pneumoniae, Escherichia coli, Streptococcus pneumoniae and the peak sputum level of CMX was 0.77±0.17 μg/g after from 2 hours to 4 hours. Among the 11 patients with respiratory tract infections, 2 patients showed excellent, 6 patients good, 3 patients poor results (isolated organisms of sputum were normal flora) and no side effects observed. |
| doi_str_mv | 10.11553/antibiotics1968b.38.1638 |
| format | Article |
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The peak serum level of CMX was 102.2±11.4 μg/ml after 1 hour drip infusion, then declined and was 3.5±10.55 μg/ml after 5 hours. Sputum level of CMX was lower than serum level but it was able to cover enough for MIC of Haemophilus influenzae, Klebsiella pneumoniae, Escherichia coli, Streptococcus pneumoniae and the peak sputum level of CMX was 0.77±0.17 μg/g after from 2 hours to 4 hours. 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J. Antibiotics</addtitle><description>In 11 patients with respiratory tract infections, the concentrations of cefmenoxime (CMX) in serum and sputum after 1 hour intravenous administration of 2 g of CMX were investigated. The peak serum level of CMX was 102.2±11.4 μg/ml after 1 hour drip infusion, then declined and was 3.5±10.55 μg/ml after 5 hours. Sputum level of CMX was lower than serum level but it was able to cover enough for MIC of Haemophilus influenzae, Klebsiella pneumoniae, Escherichia coli, Streptococcus pneumoniae and the peak sputum level of CMX was 0.77±0.17 μg/g after from 2 hours to 4 hours. Among the 11 patients with respiratory tract infections, 2 patients showed excellent, 6 patients good, 3 patients poor results (isolated organisms of sputum were normal flora) and no side effects observed.</description><subject>Adult</subject><subject>Aged</subject><subject>Cefmenoxime</subject><subject>Cefotaxime - analogs & derivatives</subject><subject>Cefotaxime - blood</subject><subject>Cefotaxime - metabolism</subject><subject>Cefotaxime - therapeutic use</subject><subject>Drug Evaluation</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Respiratory Tract Infections - drug therapy</subject><subject>Respiratory Tract Infections - metabolism</subject><subject>Sputum - analysis</subject><issn>0368-2781</issn><issn>2186-5477</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE1Pg0AQhjdGU5van2CyXrxR94Nddo8EFyVSaIAaPZGFLoqhHwI9-O-laVMTLzPJPO-8mXkBuMNohjFj9EFv-rqot31ddlhyUcyomGFOxQUYEyy4xWzHuQRjRLmwiCPwNZh2XV0gih1BBosRGFHBiRB4DOapSpZzGKpXFabQjR5hulhmf5PYh57y5yqK34K5gnEEE5UugsTN4uQdZonrZTCIfOVlQRylN-Cq0k1npqc-AUtfZd6zFcZPgeeG1hceDrCk5qRCSBJO6UpSRKi2GSOGcVFRrm1JGEF2WQotkSgdZmhFTLlyCl1QgZGkE3B_9N212--96fp8XXelaRq9Mdt9lzvcRkhINghvT8J9sTarfNfWa93-5Kf_B_5y5F9drz_Mmet2SLcx-f-oh8WcH8oh77Oq_NRtbjb0F1zndIM</recordid><startdate>198506</startdate><enddate>198506</enddate><creator>ISHIKAWA, JUJIRO</creator><creator>NAKATANI, SHIGERU</creator><creator>NINOMARU, SHINYA</creator><creator>SASAKI, TAKAO</creator><creator>KOSHOBU, TOMOAKI</creator><creator>MATSUMOTO, YUKIO</creator><general>Japan Antibiotics Research Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198506</creationdate><title>SERUM LEVELS AND SPUTUM LEVELS OF CEFMENOXIME ON RESPIRATORY TRACT INFECTIONS</title><author>ISHIKAWA, JUJIRO ; NAKATANI, SHIGERU ; NINOMARU, SHINYA ; SASAKI, TAKAO ; KOSHOBU, TOMOAKI ; MATSUMOTO, YUKIO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j1211-9a62f0092633d93023a4552e568f36a4925204cc8a908c75e3f2ecd7bab381093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1985</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Cefmenoxime</topic><topic>Cefotaxime - analogs & derivatives</topic><topic>Cefotaxime - blood</topic><topic>Cefotaxime - metabolism</topic><topic>Cefotaxime - therapeutic use</topic><topic>Drug Evaluation</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Respiratory Tract Infections - drug therapy</topic><topic>Respiratory Tract Infections - metabolism</topic><topic>Sputum - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ISHIKAWA, JUJIRO</creatorcontrib><creatorcontrib>NAKATANI, SHIGERU</creatorcontrib><creatorcontrib>NINOMARU, SHINYA</creatorcontrib><creatorcontrib>SASAKI, TAKAO</creatorcontrib><creatorcontrib>KOSHOBU, TOMOAKI</creatorcontrib><creatorcontrib>MATSUMOTO, YUKIO</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ISHIKAWA, JUJIRO</au><au>NAKATANI, SHIGERU</au><au>NINOMARU, SHINYA</au><au>SASAKI, TAKAO</au><au>KOSHOBU, TOMOAKI</au><au>MATSUMOTO, YUKIO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SERUM LEVELS AND SPUTUM LEVELS OF CEFMENOXIME ON RESPIRATORY TRACT INFECTIONS</atitle><jtitle>Japanese journal of antibiotics</jtitle><addtitle>Jpn. J. Antibiotics</addtitle><date>1985-06</date><risdate>1985</risdate><volume>38</volume><issue>6</issue><spage>1638</spage><epage>1642</epage><pages>1638-1642</pages><issn>0368-2781</issn><eissn>2186-5477</eissn><abstract>In 11 patients with respiratory tract infections, the concentrations of cefmenoxime (CMX) in serum and sputum after 1 hour intravenous administration of 2 g of CMX were investigated. The peak serum level of CMX was 102.2±11.4 μg/ml after 1 hour drip infusion, then declined and was 3.5±10.55 μg/ml after 5 hours. Sputum level of CMX was lower than serum level but it was able to cover enough for MIC of Haemophilus influenzae, Klebsiella pneumoniae, Escherichia coli, Streptococcus pneumoniae and the peak sputum level of CMX was 0.77±0.17 μg/g after from 2 hours to 4 hours. Among the 11 patients with respiratory tract infections, 2 patients showed excellent, 6 patients good, 3 patients poor results (isolated organisms of sputum were normal flora) and no side effects observed.</abstract><cop>Japan</cop><pub>Japan Antibiotics Research Association</pub><pmid>3862881</pmid><doi>10.11553/antibiotics1968b.38.1638</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0368-2781 |
| ispartof | The Japanese Journal of Antibiotics, 1985/06/25, Vol.38(6), pp.1638-1642 |
| issn | 0368-2781 2186-5477 |
| language | jpn |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Cefmenoxime Cefotaxime - analogs & derivatives Cefotaxime - blood Cefotaxime - metabolism Cefotaxime - therapeutic use Drug Evaluation Female Humans Male Middle Aged Respiratory Tract Infections - drug therapy Respiratory Tract Infections - metabolism Sputum - analysis |
| title | SERUM LEVELS AND SPUTUM LEVELS OF CEFMENOXIME ON RESPIRATORY TRACT INFECTIONS |
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