The crystal structure of human CskSH3: structural diversity near the RT-Src and n-Src loop

SH3 domains are modules occurring in diverse proteins, ranging from cytoskeletal proteins to signaling proteins, such as tyrosine kinases. The crystal structure of the SH3 domain of Csk (c-Src specific tyrosine kinase) has been refined at a resolution of 2.5 Å, with an R-factor of 22.4%. The structu...

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Veröffentlicht in:	FEBS letters 1994-03, Vol.341 (1), p.79-85
Hauptverfasser:	Borchert, T.V., Mathieu, M., Zeelen, J.Ph, Courtneidge, S.A., Wierenga, R.K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analytical, structural and metabolic biochemistry Averaging Biological and medical sciences Cloning, Molecular Conserved Sequence Crystal structure Crystalline structure Crystallography, X-Ray Csk DTT, 1,4-dithiothreitol EDTA, ethylenediaminetetraacetic acid Enzymes and enzyme inhibitors Escherichia coli Fundamental and applied biological sciences. Psychology Fyn Humans Molecular biophysics Molecular Sequence Data Protein Folding Protein Structure, Secondary Protein-Tyrosine Kinases - chemistry Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins - chemistry Proto-Oncogene Proteins c-fyn Proto-Oncogene Proteins pp60(c-src) Src src-Family Kinases Structure in molecular biology TEA, triethanolamine Transferases Tyrosine kinase
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