Methodological considerations in measurement of the P300 component of the auditory oddball ERP in schizophrenia
Twenty-three schizophrenic patients and 26 age-matched control subjects were studied using the P300 recorded during the auditory oddball task, with counting. Our aim was to assess the most suitable method of measurement and analysis of P300 amplitude and latency for use in clinical studies of schizo...
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Veröffentlicht in: | Electroencephalography and clinical neurophysiology 1994-02, Vol.90 (2), p.123-134 |
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container_title | Electroencephalography and clinical neurophysiology |
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creator | Glabus, M.F. Blackwood, D.H.R. Ebmeier, K.P. Souza, V. Walker, M.T. Sharp, C.W. Dunan, J.T. Muir, W. |
description | Twenty-three schizophrenic patients and 26 age-matched control subjects were studied using the P300 recorded during the auditory oddball task, with counting. Our aim was to assess the most suitable method of measurement and analysis of P300 amplitude and latency for use in clinical studies of schizophrenia. The effect of high-pass filtering, peak definition method and recording electrode site were all investigated. We have developed a technique, based on a least-mean-squares approximation to data, which seems particularly well suited to dealing with multi-peak P300 complexes. We have also investigated the spectral composition of the P300 and have found some evidence to support a proposed 2-frequency model of the P300 complex. |
doi_str_mv | 10.1016/0013-4694(94)90004-3 |
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subjects | Acoustic Stimulation Analysis of Variance Brain - physiopathology Electroencephalography - methods Event-related potentials Evoked Potentials, Auditory - physiology High-pass filter Humans P300 Reaction Time - physiology Schizophrenia Schizophrenia - physiopathology Spectral analysis |
title | Methodological considerations in measurement of the P300 component of the auditory oddball ERP in schizophrenia |
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