Cytotoxic T Lymphocytes Directed against MAIDS-Associated Tumors and Cells from Mice Infected by the LP-BM5 MAIDS Defective Retrovirus
The LP-BM5 retrovirus, a complex containing ecotropic helper, recombinant MCF, and defective retroviruses, causes an immunodeficiency-termed mouse AIDS (MAIDS). Many disease features of MAIDS resemble those of AIDS, including terminal B cell lymphomas. Previously we generated from MAIDS-susceptible...
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| Veröffentlicht in: | Virology (New York, N.Y.) N.Y.), 1994-04, Vol.200 (1), p.292-296 |
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| creator | Green, William R. Crassi, Karen M. Schwarz, David A. Green, Kathy A. |
| description | The LP-BM5 retrovirus, a complex containing ecotropic helper, recombinant MCF, and defective retroviruses, causes an immunodeficiency-termed mouse AIDS (MAIDS). Many disease features of MAIDS resemble those of AIDS, including terminal B cell lymphomas. Previously we generated from MAIDS-susceptible C57BL/6 mice cytolytic T lymphocytes (CTL) specific for MAIDS-associated B cell lymphomas. Data of the present study (1) exclude MCF and establish a role for defective virus in generating C57BL/6 CTL to MAIDS-associated tumors by experiments involving in vitro stimulation with cells from LP-BM5, ecotropic, or ecotropic-rescued defective virus-infected mice and (2) confirm that such CTL are specific for tumors of MAIDS origin. Several approaches testing for direct involvement of defective virus or its gag-encoded polyprotein, however, did not provide evidence that MAIDS tumor-specific CTL were directed to structural virion proteins, suggesting the possibility that such CTL are specific for nonvirion antigens whose expression depends on the action of the defective genome in the MAIDS disease process. |
| doi_str_mv | 10.1006/viro.1994.1189 |
| format | Article |
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Many disease features of MAIDS resemble those of AIDS, including terminal B cell lymphomas. Previously we generated from MAIDS-susceptible C57BL/6 mice cytolytic T lymphocytes (CTL) specific for MAIDS-associated B cell lymphomas. Data of the present study (1) exclude MCF and establish a role for defective virus in generating C57BL/6 CTL to MAIDS-associated tumors by experiments involving in vitro stimulation with cells from LP-BM5, ecotropic, or ecotropic-rescued defective virus-infected mice and (2) confirm that such CTL are specific for tumors of MAIDS origin. Several approaches testing for direct involvement of defective virus or its gag-encoded polyprotein, however, did not provide evidence that MAIDS tumor-specific CTL were directed to structural virion proteins, suggesting the possibility that such CTL are specific for nonvirion antigens whose expression depends on the action of the defective genome in the MAIDS disease process.</description><identifier>ISSN: 0042-6822</identifier><identifier>EISSN: 1096-0341</identifier><identifier>DOI: 10.1006/viro.1994.1189</identifier><identifier>PMID: 8128630</identifier><identifier>CODEN: VIRLAX</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>AIDS/HIV ; Animals ; Biological and medical sciences ; Defective Viruses ; Fundamental and applied biological sciences. Psychology ; Gene Products, gag - immunology ; Leukemia Virus, Murine ; Lymphoma, B-Cell - complications ; Lymphoma, B-Cell - immunology ; Male ; Mice ; Mice, Inbred C57BL ; Microbiology ; Murine Acquired Immunodeficiency Syndrome - complications ; Murine Acquired Immunodeficiency Syndrome - immunology ; murine leukemia virus ; Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains ; T-Lymphocytes, Cytotoxic - immunology ; Virology</subject><ispartof>Virology (New York, N.Y.), 1994-04, Vol.200 (1), p.292-296</ispartof><rights>1994 Academic Press</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-d05f64860b5c970593df501ab4bad6a1291dc0b48a189ca7f11a1dc630699b8e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/viro.1994.1189$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4057904$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8128630$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Green, William R.</creatorcontrib><creatorcontrib>Crassi, Karen M.</creatorcontrib><creatorcontrib>Schwarz, David A.</creatorcontrib><creatorcontrib>Green, Kathy A.</creatorcontrib><title>Cytotoxic T Lymphocytes Directed against MAIDS-Associated Tumors and Cells from Mice Infected by the LP-BM5 MAIDS Defective Retrovirus</title><title>Virology (New York, N.Y.)</title><addtitle>Virology</addtitle><description>The LP-BM5 retrovirus, a complex containing ecotropic helper, recombinant MCF, and defective retroviruses, causes an immunodeficiency-termed mouse AIDS (MAIDS). Many disease features of MAIDS resemble those of AIDS, including terminal B cell lymphomas. Previously we generated from MAIDS-susceptible C57BL/6 mice cytolytic T lymphocytes (CTL) specific for MAIDS-associated B cell lymphomas. Data of the present study (1) exclude MCF and establish a role for defective virus in generating C57BL/6 CTL to MAIDS-associated tumors by experiments involving in vitro stimulation with cells from LP-BM5, ecotropic, or ecotropic-rescued defective virus-infected mice and (2) confirm that such CTL are specific for tumors of MAIDS origin. Several approaches testing for direct involvement of defective virus or its gag-encoded polyprotein, however, did not provide evidence that MAIDS tumor-specific CTL were directed to structural virion proteins, suggesting the possibility that such CTL are specific for nonvirion antigens whose expression depends on the action of the defective genome in the MAIDS disease process.</description><subject>AIDS/HIV</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Defective Viruses</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Products, gag - immunology</subject><subject>Leukemia Virus, Murine</subject><subject>Lymphoma, B-Cell - complications</subject><subject>Lymphoma, B-Cell - immunology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Microbiology</subject><subject>Murine Acquired Immunodeficiency Syndrome - complications</subject><subject>Murine Acquired Immunodeficiency Syndrome - immunology</subject><subject>murine leukemia virus</subject><subject>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><subject>Virology</subject><issn>0042-6822</issn><issn>1096-0341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU-P0zAQxS0EWsrClRuSD2hv6dqJ49jH0vKnUqtFUM6W40xYoyYutlORL8DnXodUe1txssbvN08z8xB6S8mSEsJvz9a7JZWSLSkV8hlaUCJ5RgpGn6MFISzPuMjzl-hVCL9IqquKXKErQXPBC7JAf9djdNH9sQYf8G7sTvfOjBEC3lgPJkKD9U9t-xDxfrXdfM9WIThj9SQchs75gHXf4DUcjwG33nV4bw3gbd_OzfWI4z3g3dfsw76cLfAGJtGeAX-D6F1aYAiv0YtWHwO8ubzX6Menj4f1l2x393m7Xu0ywwoZs4aULWeCk7o0siKlLJq2JFTXrNYN1zSXtDGkZkKnWxhdtZTq9JM25VLWAoprdDP7nrz7PUCIqrPBpOl1D24IquKFLGmV_xekXMiKFjKByxk03oXgoVUnbzvtR0WJmhJSU0JqSkhNCaWGdxfnoe6gecQvkST9_UXXwehj63VvbHjEGCkrSVjCxIxBOtfZglfBWOgNNP-CU42zT03wAMV4rB0</recordid><startdate>19940401</startdate><enddate>19940401</enddate><creator>Green, William R.</creator><creator>Crassi, Karen M.</creator><creator>Schwarz, David A.</creator><creator>Green, Kathy A.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19940401</creationdate><title>Cytotoxic T Lymphocytes Directed against MAIDS-Associated Tumors and Cells from Mice Infected by the LP-BM5 MAIDS Defective Retrovirus</title><author>Green, William R. ; Crassi, Karen M. ; Schwarz, David A. ; Green, Kathy A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-d05f64860b5c970593df501ab4bad6a1291dc0b48a189ca7f11a1dc630699b8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>AIDS/HIV</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Defective Viruses</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Products, gag - immunology</topic><topic>Leukemia Virus, Murine</topic><topic>Lymphoma, B-Cell - complications</topic><topic>Lymphoma, B-Cell - immunology</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Microbiology</topic><topic>Murine Acquired Immunodeficiency Syndrome - complications</topic><topic>Murine Acquired Immunodeficiency Syndrome - immunology</topic><topic>murine leukemia virus</topic><topic>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</topic><topic>T-Lymphocytes, Cytotoxic - immunology</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Green, William R.</creatorcontrib><creatorcontrib>Crassi, Karen M.</creatorcontrib><creatorcontrib>Schwarz, David A.</creatorcontrib><creatorcontrib>Green, Kathy A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Virology (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Green, William R.</au><au>Crassi, Karen M.</au><au>Schwarz, David A.</au><au>Green, Kathy A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytotoxic T Lymphocytes Directed against MAIDS-Associated Tumors and Cells from Mice Infected by the LP-BM5 MAIDS Defective Retrovirus</atitle><jtitle>Virology (New York, N.Y.)</jtitle><addtitle>Virology</addtitle><date>1994-04-01</date><risdate>1994</risdate><volume>200</volume><issue>1</issue><spage>292</spage><epage>296</epage><pages>292-296</pages><issn>0042-6822</issn><eissn>1096-0341</eissn><coden>VIRLAX</coden><abstract>The LP-BM5 retrovirus, a complex containing ecotropic helper, recombinant MCF, and defective retroviruses, causes an immunodeficiency-termed mouse AIDS (MAIDS). Many disease features of MAIDS resemble those of AIDS, including terminal B cell lymphomas. Previously we generated from MAIDS-susceptible C57BL/6 mice cytolytic T lymphocytes (CTL) specific for MAIDS-associated B cell lymphomas. Data of the present study (1) exclude MCF and establish a role for defective virus in generating C57BL/6 CTL to MAIDS-associated tumors by experiments involving in vitro stimulation with cells from LP-BM5, ecotropic, or ecotropic-rescued defective virus-infected mice and (2) confirm that such CTL are specific for tumors of MAIDS origin. Several approaches testing for direct involvement of defective virus or its gag-encoded polyprotein, however, did not provide evidence that MAIDS tumor-specific CTL were directed to structural virion proteins, suggesting the possibility that such CTL are specific for nonvirion antigens whose expression depends on the action of the defective genome in the MAIDS disease process.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>8128630</pmid><doi>10.1006/viro.1994.1189</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Access via ScienceDirect (Elsevier) |
| subjects | AIDS/HIV Animals Biological and medical sciences Defective Viruses Fundamental and applied biological sciences. Psychology Gene Products, gag - immunology Leukemia Virus, Murine Lymphoma, B-Cell - complications Lymphoma, B-Cell - immunology Male Mice Mice, Inbred C57BL Microbiology Murine Acquired Immunodeficiency Syndrome - complications Murine Acquired Immunodeficiency Syndrome - immunology murine leukemia virus Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains T-Lymphocytes, Cytotoxic - immunology Virology |
| title | Cytotoxic T Lymphocytes Directed against MAIDS-Associated Tumors and Cells from Mice Infected by the LP-BM5 MAIDS Defective Retrovirus |
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