Cardiovascular Effects of Nicardipine in Anesthetized Open-Chest Dogs in the Absence and Presence of β-Adrenergic Receptor Blockade: A Comparison with Nifedipine and Verapamil

Nicardipine, a new 1,4-dihydropyridine calcium-entry blocker, was assessed for cardiovascular effects against nifedipine and verapamil in anesthetized open-chest beagle dogs, in the absence and presence of β-adrenoceptor blockade (propranolol 1 mg/kg i.v.). In control conditions, intravenous nicardi...

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