Comparison of activity of alpha-adrenoceptor agonists and antagonists in dog and rabbit saphenous vein
The alpha adrenoceptors present on the saphenous vein of the dog and rabbit were characterised in vitro using the selective alpha 1 antagonist prazosin and the alpha 2 antagonists rauwolscine and yohimbine. In the dog saphenous vein, prazosin and rauwolscine competitively antagonised contractile res...
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| Veröffentlicht in: | Naunyn-Schmiedeberg's archives of pharmacology 1985-07, Vol.330 (1), p.33-36 |
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| creator | Alabaster, V A Keir, R F Peters, C J |
| description | The alpha adrenoceptors present on the saphenous vein of the dog and rabbit were characterised in vitro using the selective alpha 1 antagonist prazosin and the alpha 2 antagonists rauwolscine and yohimbine. In the dog saphenous vein, prazosin and rauwolscine competitively antagonised contractile responses to phenylephrine and UK-14,304 respectively. Noradrenaline was competitively blocked by prazosin only. In contrast, phenylephrine and methoxamine-induced responses in the rabbit saphenous vein were insensitive to prazosin and corynanthine. Rauwolscine competitively blocked responses to UK-14,304, noradrenaline and phenylephrine and pA2 values were similar against each agonist. Noradrenaline and UK-14,304 were equipotent agonists on the rabbit saphenous vein while in the dog vein noradrenaline has a lower potency than UK-14,304. These results suggest that the dog saphenous vein has a mixed population of alpha adrenoceptors, while the alpha adrenoceptors on the rabbit vein are homogeneous, with characteristics of the alpha 2 subtype. |
| doi_str_mv | 10.1007/BF00586706 |
| format | Article |
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In the dog saphenous vein, prazosin and rauwolscine competitively antagonised contractile responses to phenylephrine and UK-14,304 respectively. Noradrenaline was competitively blocked by prazosin only. In contrast, phenylephrine and methoxamine-induced responses in the rabbit saphenous vein were insensitive to prazosin and corynanthine. Rauwolscine competitively blocked responses to UK-14,304, noradrenaline and phenylephrine and pA2 values were similar against each agonist. Noradrenaline and UK-14,304 were equipotent agonists on the rabbit saphenous vein while in the dog vein noradrenaline has a lower potency than UK-14,304. These results suggest that the dog saphenous vein has a mixed population of alpha adrenoceptors, while the alpha adrenoceptors on the rabbit vein are homogeneous, with characteristics of the alpha 2 subtype.</description><identifier>ISSN: 0028-1298</identifier><identifier>EISSN: 1432-1912</identifier><identifier>DOI: 10.1007/BF00586706</identifier><identifier>PMID: 2864638</identifier><language>eng</language><publisher>Germany</publisher><subject>Adrenergic alpha-Agonists - pharmacology ; Adrenergic alpha-Antagonists - pharmacology ; Animals ; Male ; Muscle Contraction - drug effects ; Muscle, Smooth, Vascular - drug effects ; Norepinephrine - pharmacology ; Phenylephrine - pharmacology ; Prazosin - pharmacology ; Rabbits ; Saphenous Vein - drug effects ; Species Specificity ; Yohimbine - pharmacology</subject><ispartof>Naunyn-Schmiedeberg's archives of pharmacology, 1985-07, Vol.330 (1), p.33-36</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c313t-4c7bfb1e22105d3500dcddf2393d1870d33dbddb5ca52861deff59188abe035e3</citedby><cites>FETCH-LOGICAL-c313t-4c7bfb1e22105d3500dcddf2393d1870d33dbddb5ca52861deff59188abe035e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2864638$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alabaster, V A</creatorcontrib><creatorcontrib>Keir, R F</creatorcontrib><creatorcontrib>Peters, C J</creatorcontrib><title>Comparison of activity of alpha-adrenoceptor agonists and antagonists in dog and rabbit saphenous vein</title><title>Naunyn-Schmiedeberg's archives of pharmacology</title><addtitle>Naunyn Schmiedebergs Arch Pharmacol</addtitle><description>The alpha adrenoceptors present on the saphenous vein of the dog and rabbit were characterised in vitro using the selective alpha 1 antagonist prazosin and the alpha 2 antagonists rauwolscine and yohimbine. In the dog saphenous vein, prazosin and rauwolscine competitively antagonised contractile responses to phenylephrine and UK-14,304 respectively. Noradrenaline was competitively blocked by prazosin only. In contrast, phenylephrine and methoxamine-induced responses in the rabbit saphenous vein were insensitive to prazosin and corynanthine. Rauwolscine competitively blocked responses to UK-14,304, noradrenaline and phenylephrine and pA2 values were similar against each agonist. Noradrenaline and UK-14,304 were equipotent agonists on the rabbit saphenous vein while in the dog vein noradrenaline has a lower potency than UK-14,304. These results suggest that the dog saphenous vein has a mixed population of alpha adrenoceptors, while the alpha adrenoceptors on the rabbit vein are homogeneous, with characteristics of the alpha 2 subtype.</description><subject>Adrenergic alpha-Agonists - pharmacology</subject><subject>Adrenergic alpha-Antagonists - pharmacology</subject><subject>Animals</subject><subject>Male</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle, Smooth, Vascular - drug effects</subject><subject>Norepinephrine - pharmacology</subject><subject>Phenylephrine - pharmacology</subject><subject>Prazosin - pharmacology</subject><subject>Rabbits</subject><subject>Saphenous Vein - drug effects</subject><subject>Species Specificity</subject><subject>Yohimbine - pharmacology</subject><issn>0028-1298</issn><issn>1432-1912</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDtPwzAQgC0EKqWwsCNlYkAKnO06cUaoKCBVYoE58rM1SuJgu0j996QPlZHBOt_pu9Pdh9A1hnsMUD48zQEYL0ooTtAYTynJcYXJKRoDEJ5jUvFzdBHjFwAUmLERGhFeTAvKx8jOfNuL4KLvMm8zoZL7cWmz-zf9SuRCB9N5ZfrkQyaWvnMxxUx0enjpmLsu0365KwchpUtZFP1qaFzH7Me47hKdWdFEc3WIE_Q5f_6YveaL95e32eMiVxTTlE9VKa3EhhAMTFMGoJXWltCKasxL0JRqqbVkSrDhBKyNtazCnAtpgDJDJ-h2P7cP_nttYqpbF5VpGtGZYZe6LGhFeFn9C24tDmrZAN7tQRV8jMHYug-uFWFTY6i39us_-wN8c5i6lq3RR_Sgm_4CaaGAig</recordid><startdate>198507</startdate><enddate>198507</enddate><creator>Alabaster, V A</creator><creator>Keir, R F</creator><creator>Peters, C J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>198507</creationdate><title>Comparison of activity of alpha-adrenoceptor agonists and antagonists in dog and rabbit saphenous vein</title><author>Alabaster, V A ; Keir, R F ; Peters, C J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c313t-4c7bfb1e22105d3500dcddf2393d1870d33dbddb5ca52861deff59188abe035e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adrenergic alpha-Agonists - pharmacology</topic><topic>Adrenergic alpha-Antagonists - pharmacology</topic><topic>Animals</topic><topic>Male</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle, Smooth, Vascular - drug effects</topic><topic>Norepinephrine - pharmacology</topic><topic>Phenylephrine - pharmacology</topic><topic>Prazosin - pharmacology</topic><topic>Rabbits</topic><topic>Saphenous Vein - drug effects</topic><topic>Species Specificity</topic><topic>Yohimbine - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alabaster, V A</creatorcontrib><creatorcontrib>Keir, R F</creatorcontrib><creatorcontrib>Peters, C J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Naunyn-Schmiedeberg's archives of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alabaster, V A</au><au>Keir, R F</au><au>Peters, C J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of activity of alpha-adrenoceptor agonists and antagonists in dog and rabbit saphenous vein</atitle><jtitle>Naunyn-Schmiedeberg's archives of pharmacology</jtitle><addtitle>Naunyn Schmiedebergs Arch Pharmacol</addtitle><date>1985-07</date><risdate>1985</risdate><volume>330</volume><issue>1</issue><spage>33</spage><epage>36</epage><pages>33-36</pages><issn>0028-1298</issn><eissn>1432-1912</eissn><abstract>The alpha adrenoceptors present on the saphenous vein of the dog and rabbit were characterised in vitro using the selective alpha 1 antagonist prazosin and the alpha 2 antagonists rauwolscine and yohimbine. 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| ispartof | Naunyn-Schmiedeberg's archives of pharmacology, 1985-07, Vol.330 (1), p.33-36 |
| issn | 0028-1298 1432-1912 |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adrenergic alpha-Agonists - pharmacology Adrenergic alpha-Antagonists - pharmacology Animals Male Muscle Contraction - drug effects Muscle, Smooth, Vascular - drug effects Norepinephrine - pharmacology Phenylephrine - pharmacology Prazosin - pharmacology Rabbits Saphenous Vein - drug effects Species Specificity Yohimbine - pharmacology |
| title | Comparison of activity of alpha-adrenoceptor agonists and antagonists in dog and rabbit saphenous vein |
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