Impaired immune and acute-phase responses in interleukin-6-deficient mice

Interleukin-6 (IL-6) is a multifunctional cytokine that regulates various aspects of the immune response, acute-phase reaction and haematopoiesis (for reviews see refs 1, 2). In vitro, leukaemia inhibitory factor, oncostatin M, ciliary neurotrophic factor and interleukin-11 display overlapping activ...

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Veröffentlicht in:	Nature (London) 1994-03, Vol.368 (6469), p.339-342
Hauptverfasser:	KOPF, M, BAUMANN, H, FREER, G, FREUDENBERG, M, LAMERS, M, KISHIMOTO, T, ZINKERNAGEL, R, BLUETHMANN, H, KÖHLER, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute-Phase Reaction - immunology Analysis of the immune response. Humoral and cellular immunity Animals B-Lymphocytes - immunology Biochemistry Biological and medical sciences Fundamental and applied biological sciences. Psychology Fundamental immunology Genes Immune response Immune system Immunity (Disease) Immunity - immunology Immunity - physiology Immunobiology Interleukin-6 - deficiency Interleukin-6 - genetics Interleukin-6 - physiology Leukemia Listeria monocytogenes Listeriosis - immunology Lymphocytes Lymphoid Tissue - embryology Lymphoid Tissue - immunology Lymphokines, interleukins ( function, expression) Mice Mice, Inbred C57BL Regulatory factors and their cellular receptors Rhabdoviridae Infections - immunology RNA, Messenger - metabolism Rodents T-Lymphocytes - immunology Vaccinia virus Vesicular stomatitis Indiana virus - immunology Vesicular stomatitis virus
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