Impaired immune and acute-phase responses in interleukin-6-deficient mice
Interleukin-6 (IL-6) is a multifunctional cytokine that regulates various aspects of the immune response, acute-phase reaction and haematopoiesis (for reviews see refs 1, 2). In vitro, leukaemia inhibitory factor, oncostatin M, ciliary neurotrophic factor and interleukin-11 display overlapping activ...
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| Veröffentlicht in: | Nature (London) 1994-03, Vol.368 (6469), p.339-342 |
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| creator | KOPF, M BAUMANN, H FREER, G FREUDENBERG, M LAMERS, M KISHIMOTO, T ZINKERNAGEL, R BLUETHMANN, H KÖHLER, G |
| description | Interleukin-6 (IL-6) is a multifunctional cytokine that regulates various aspects of the immune response, acute-phase reaction and haematopoiesis (for reviews see refs 1, 2). In vitro, leukaemia inhibitory factor, oncostatin M, ciliary neurotrophic factor and interleukin-11 display overlapping activities with IL-6. This functional redundancy may be explained by the interactions of specific binding receptors with a common signal-transducing receptor (gp130) (for reviews see refs 3, 4). To elucidate the unique function of IL-6 in vivo, we have disrupted the IL-6 gene by homologous recombination. IL-6-deficient mice develop normally. They fail to control efficiently vaccinia virus and infection with Listeria monocytogenes, a facultative intracellular bacterium. The T-cell-dependent antibody response against vesicular stomatitis virus is impaired. Further, the inflammatory acute-phase response after tissue damage or infection is severely compromised, whereas it is only moderately affected after challenge with lipopolysaccharide. We conclude that IL-6 production induced by injury or infection is an important in vivo SOS signal which coordinates activities of liver cells, macrophages and lymphocytes. |
| doi_str_mv | 10.1038/368339a0 |
| format | Article |
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In vitro, leukaemia inhibitory factor, oncostatin M, ciliary neurotrophic factor and interleukin-11 display overlapping activities with IL-6. This functional redundancy may be explained by the interactions of specific binding receptors with a common signal-transducing receptor (gp130) (for reviews see refs 3, 4). To elucidate the unique function of IL-6 in vivo, we have disrupted the IL-6 gene by homologous recombination. IL-6-deficient mice develop normally. They fail to control efficiently vaccinia virus and infection with Listeria monocytogenes, a facultative intracellular bacterium. The T-cell-dependent antibody response against vesicular stomatitis virus is impaired. Further, the inflammatory acute-phase response after tissue damage or infection is severely compromised, whereas it is only moderately affected after challenge with lipopolysaccharide. We conclude that IL-6 production induced by injury or infection is an important in vivo SOS signal which coordinates activities of liver cells, macrophages and lymphocytes.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/368339a0</identifier><identifier>PMID: 8127368</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing</publisher><subject>Acute-Phase Reaction - immunology ; Analysis of the immune response. Humoral and cellular immunity ; Animals ; B-Lymphocytes - immunology ; Biochemistry ; Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Genes ; Immune response ; Immune system ; Immunity (Disease) ; Immunity - immunology ; Immunity - physiology ; Immunobiology ; Interleukin-6 - deficiency ; Interleukin-6 - genetics ; Interleukin-6 - physiology ; Leukemia ; Listeria monocytogenes ; Listeriosis - immunology ; Lymphocytes ; Lymphoid Tissue - embryology ; Lymphoid Tissue - immunology ; Lymphokines, interleukins ( function, expression) ; Mice ; Mice, Inbred C57BL ; Regulatory factors and their cellular receptors ; Rhabdoviridae Infections - immunology ; RNA, Messenger - metabolism ; Rodents ; T-Lymphocytes - immunology ; Vaccinia virus ; Vesicular stomatitis Indiana virus - immunology ; Vesicular stomatitis virus</subject><ispartof>Nature (London), 1994-03, Vol.368 (6469), p.339-342</ispartof><rights>1994 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. 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In vitro, leukaemia inhibitory factor, oncostatin M, ciliary neurotrophic factor and interleukin-11 display overlapping activities with IL-6. This functional redundancy may be explained by the interactions of specific binding receptors with a common signal-transducing receptor (gp130) (for reviews see refs 3, 4). To elucidate the unique function of IL-6 in vivo, we have disrupted the IL-6 gene by homologous recombination. IL-6-deficient mice develop normally. They fail to control efficiently vaccinia virus and infection with Listeria monocytogenes, a facultative intracellular bacterium. The T-cell-dependent antibody response against vesicular stomatitis virus is impaired. Further, the inflammatory acute-phase response after tissue damage or infection is severely compromised, whereas it is only moderately affected after challenge with lipopolysaccharide. We conclude that IL-6 production induced by injury or infection is an important in vivo SOS signal which coordinates activities of liver cells, macrophages and lymphocytes.</description><subject>Acute-Phase Reaction - immunology</subject><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>Animals</subject><subject>B-Lymphocytes - immunology</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Genes</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunity (Disease)</subject><subject>Immunity - immunology</subject><subject>Immunity - physiology</subject><subject>Immunobiology</subject><subject>Interleukin-6 - deficiency</subject><subject>Interleukin-6 - genetics</subject><subject>Interleukin-6 - physiology</subject><subject>Leukemia</subject><subject>Listeria monocytogenes</subject><subject>Listeriosis - immunology</subject><subject>Lymphocytes</subject><subject>Lymphoid Tissue - embryology</subject><subject>Lymphoid Tissue - immunology</subject><subject>Lymphokines, interleukins ( function, expression)</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Regulatory factors and their cellular receptors</subject><subject>Rhabdoviridae Infections - immunology</subject><subject>RNA, Messenger - metabolism</subject><subject>Rodents</subject><subject>T-Lymphocytes - immunology</subject><subject>Vaccinia virus</subject><subject>Vesicular stomatitis Indiana virus - immunology</subject><subject>Vesicular stomatitis virus</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkUtLxTAQhYMo1-sD_ANCERE31WmSJulSLj4uCG7clzSZYLRNa9Iu_PdWvCq4UBiYxfnmDIdDyFEBFwUwdcmEYqzSsEWWBZci50LJbbIEoCoHxcQu2UvpGQDKQvIFWaiCyvlmSdbrbtA-os18100BMx1sps00Yj486YRZxDT0IWHKfJhnxNji9OJDLnKLzhuPYcw6b_CA7DjdJjzc7H3yeHP9uLrL7x9u16ur-9xwRse8rCqunDIaQTon0UldMskUR0lt4xi3YJSzjbYUWGWV4QCuUbyRXEqgbJ-cfdoOsX-dMI1155PBttUB-ynVUjClyvIDPP8TLKQUogTO-L-ehVBUUFrO4Mkv8LmfYpjj1hQ4l5Ry9vPYxD6liK4eou90fKsLqD_aqr_amtHjjd_UdGi_wU09s3660XUyunVRB-PTN8aqCkBV7B2qw5m6</recordid><startdate>19940324</startdate><enddate>19940324</enddate><creator>KOPF, M</creator><creator>BAUMANN, H</creator><creator>FREER, G</creator><creator>FREUDENBERG, M</creator><creator>LAMERS, M</creator><creator>KISHIMOTO, T</creator><creator>ZINKERNAGEL, R</creator><creator>BLUETHMANN, H</creator><creator>KÖHLER, G</creator><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7TG</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>S0X</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>19940324</creationdate><title>Impaired immune and acute-phase responses in interleukin-6-deficient mice</title><author>KOPF, M ; BAUMANN, H ; FREER, G ; FREUDENBERG, M ; LAMERS, M ; KISHIMOTO, T ; ZINKERNAGEL, R ; BLUETHMANN, H ; KÖHLER, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-59948f8cae07ff7ef7a537384e72dbf34d0c8fdbad2039d8c400fb84b7477023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Acute-Phase Reaction - immunology</topic><topic>Analysis of the immune response. Humoral and cellular immunity</topic><topic>Animals</topic><topic>B-Lymphocytes - immunology</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Genes</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunity (Disease)</topic><topic>Immunity - immunology</topic><topic>Immunity - physiology</topic><topic>Immunobiology</topic><topic>Interleukin-6 - deficiency</topic><topic>Interleukin-6 - genetics</topic><topic>Interleukin-6 - physiology</topic><topic>Leukemia</topic><topic>Listeria monocytogenes</topic><topic>Listeriosis - immunology</topic><topic>Lymphocytes</topic><topic>Lymphoid Tissue - embryology</topic><topic>Lymphoid Tissue - immunology</topic><topic>Lymphokines, interleukins ( function, expression)</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Regulatory factors and their cellular receptors</topic><topic>Rhabdoviridae Infections - immunology</topic><topic>RNA, Messenger - metabolism</topic><topic>Rodents</topic><topic>T-Lymphocytes - immunology</topic><topic>Vaccinia virus</topic><topic>Vesicular stomatitis Indiana virus - 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We conclude that IL-6 production induced by injury or infection is an important in vivo SOS signal which coordinates activities of liver cells, macrophages and lymphocytes.</abstract><cop>London</cop><pub>Nature Publishing</pub><pmid>8127368</pmid><doi>10.1038/368339a0</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Nature (London), 1994-03, Vol.368 (6469), p.339-342 |
| issn | 0028-0836 1476-4687 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online |
| subjects | Acute-Phase Reaction - immunology Analysis of the immune response. Humoral and cellular immunity Animals B-Lymphocytes - immunology Biochemistry Biological and medical sciences Fundamental and applied biological sciences. Psychology Fundamental immunology Genes Immune response Immune system Immunity (Disease) Immunity - immunology Immunity - physiology Immunobiology Interleukin-6 - deficiency Interleukin-6 - genetics Interleukin-6 - physiology Leukemia Listeria monocytogenes Listeriosis - immunology Lymphocytes Lymphoid Tissue - embryology Lymphoid Tissue - immunology Lymphokines, interleukins ( function, expression) Mice Mice, Inbred C57BL Regulatory factors and their cellular receptors Rhabdoviridae Infections - immunology RNA, Messenger - metabolism Rodents T-Lymphocytes - immunology Vaccinia virus Vesicular stomatitis Indiana virus - immunology Vesicular stomatitis virus |
| title | Impaired immune and acute-phase responses in interleukin-6-deficient mice |
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