Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: Implications for the Cori cycle

Lactate and pyruvate cross cell membranes via a monocarboxylate transporter (MCT) with well-defined properties but undefined molecular structure. We report the cloning of a cDNA encoding MCT1, a monocarboxylate transporter whose properties resemble those of the erythrocyte MCT, including proton symp...

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Veröffentlicht in:	Cell 1994-03, Vol.76 (5), p.865-873
Hauptverfasser:	Garcia, Christine Kim, Goldstein, Joseph L., Pathak, Ravindra K., Anderson, Richard G.W., Brown, Michael S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Base Sequence Binding and carrier proteins Biological and medical sciences Biological Transport Carboxylic Acids - metabolism Carrier Proteins - genetics Carrier Proteins - metabolism Cell Membrane - metabolism Cloning, Molecular Cricetinae Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Hydrogen-Ion Concentration Male Mevalonic Acid - metabolism Molecular Sequence Data Muscles - metabolism Proteins Pyruvates - metabolism Spermatozoa - metabolism
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