STUDIES ON ANTIVIRAL AGENTS: II. SYNTHESIS AND IN VITRO ANTIVIRAL ACTIVITY ON NEW KANAMYCIN A DERIVATIVES HAVING HIGHER ACYL GROUP AT N-1 POSITION

The synthesis and antiviral activity of 3''-N-trifluoroacetylkanamycin A derivatives (6) having higher acyl group at the N-1 position are described. On the basis of the structureactivity relationships between antiviral activity and alkyl chain length in an acyl group at the N-1 position, a...

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Veröffentlicht in:	Journal of antibiotics 1985, Vol.38(8), pp.1050-1060
Hauptverfasser:	MATSUDA, KEIJI, YASUDA, NOBUYOSHI, TSUTSUMI, HIDEO, TAKAYA, TAKAO
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - chemical synthesis Antiviral Agents - pharmacology Biological and medical sciences General pharmacology Kanamycin - chemical synthesis Kanamycin - pharmacology Medical sciences Orthomyxoviridae - drug effects Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Simplexvirus - drug effects Structure-Activity Relationship
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