Stoichiometry and kinetics of the interaction of prostaglandin H synthase with anti-inflammatory agents

We have examined the kinetics, stoichiometry, and chemical nature of the interaction of three anti-inflammatory agents (indomethacin, flurbiprofen, and meclofenamic acid) with pure ovine prostaglandin H synthase. The kinetics of the interaction with the synthase for each of the three agents, monitor...

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Veröffentlicht in:	The Journal of biological chemistry 1985-10, Vol.260 (23), p.12572-12578
Hauptverfasser:	Kulmacz, R J, Lands, W E
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Arachidonic Acid Arachidonic Acids - metabolism Biological and medical sciences Cyclooxygenase Inhibitors Enzymes and enzyme inhibitors Flurbiprofen - metabolism Flurbiprofen - pharmacology Fundamental and applied biological sciences. Psychology Indomethacin - metabolism Indomethacin - pharmacology Kinetics Lyases Macromolecular Substances Male Meclofenamic Acid - metabolism Meclofenamic Acid - pharmacology ortho-Aminobenzoates - metabolism Oxygen Consumption Propionates - metabolism Prostaglandin-Endoperoxide Synthases - metabolism Protein Conformation - drug effects Seminal Vesicles - enzymology Sheep Spectrophotometry
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