Dyslipidemia and ischemic heart disease mortality among men and women with diabetes
We investigated whether the greater increased risk of ischemic heart disease mortality associated with diabetes among women compared with men could be explained by their more pronounced lipoprotein abnormalities. Seventy-six men and 45 women with diabetes and 327 men and 496 women without diabetes w...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 1994-03, Vol.89 (3), p.991-997 |
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| container_title | Circulation (New York, N.Y.) |
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| creator | GOLDSCHMID, M. G BARRETT-CONNOR, E EDELSTEIN, S. L WINGARD, D. L COHN, B. A HERMAN, W. H |
| description | We investigated whether the greater increased risk of ischemic heart disease mortality associated with diabetes among women compared with men could be explained by their more pronounced lipoprotein abnormalities.
Seventy-six men and 45 women with diabetes and 327 men and 496 women without diabetes were followed for an average of 16 years in a population-based study. Cox proportional hazards models were used to determine the relative hazard of ischemic heart disease mortality for changes in lipoprotein subfractions after adjustment for age, hypertension, obesity, smoking, exercise, alcohol consumption, and estrogen use (among women). The relative hazard of ischemic heart disease mortality among diabetic women was 1.76 (P = .10) for a 10-mg/dL decrement in high-density lipoprotein cholesterol (HDL-C) and 3.13 (P = .01) for a 1-U increment in log very-low-density lipoprotein cholesterol (VLDL-C). The risk of ischemic heart disease mortality among diabetic women relative to nondiabetic women for an HDL-C level of 50 mg/dL and a log(e) VLDL-C of 3 (about 20 mg/dL) were 4.1 and 3.4, respectively (P < .05). These lipoprotein changes were not associated with ischemic heart disease mortality among men or among nondiabetic women.
Excess ischemic heart disease mortality among diabetic women is partially explained by deleterious levels of HDL-C and VLDL-C. HDL-C levels of < or = 50 mg/dL and VLDL-C levels of > or = 20 mg/dL appear to predict ischemic heart disease mortality among these women and may help identify women who would benefit most from intervention. |
| doi_str_mv | 10.1161/01.CIR.89.3.991 |
| format | Article |
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Seventy-six men and 45 women with diabetes and 327 men and 496 women without diabetes were followed for an average of 16 years in a population-based study. Cox proportional hazards models were used to determine the relative hazard of ischemic heart disease mortality for changes in lipoprotein subfractions after adjustment for age, hypertension, obesity, smoking, exercise, alcohol consumption, and estrogen use (among women). The relative hazard of ischemic heart disease mortality among diabetic women was 1.76 (P = .10) for a 10-mg/dL decrement in high-density lipoprotein cholesterol (HDL-C) and 3.13 (P = .01) for a 1-U increment in log very-low-density lipoprotein cholesterol (VLDL-C). The risk of ischemic heart disease mortality among diabetic women relative to nondiabetic women for an HDL-C level of 50 mg/dL and a log(e) VLDL-C of 3 (about 20 mg/dL) were 4.1 and 3.4, respectively (P < .05). These lipoprotein changes were not associated with ischemic heart disease mortality among men or among nondiabetic women.
Excess ischemic heart disease mortality among diabetic women is partially explained by deleterious levels of HDL-C and VLDL-C. HDL-C levels of < or = 50 mg/dL and VLDL-C levels of > or = 20 mg/dL appear to predict ischemic heart disease mortality among these women and may help identify women who would benefit most from intervention.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.CIR.89.3.991</identifier><identifier>PMID: 8124839</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Associated diseases and complications ; Biological and medical sciences ; California - epidemiology ; Cholesterol, HDL - blood ; Cholesterol, VLDL - blood ; Cohort Studies ; Diabetes Mellitus - blood ; Diabetes Mellitus - epidemiology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Female ; Follow-Up Studies ; Humans ; Male ; Medical sciences ; Middle Aged ; Myocardial Ischemia - mortality ; Proportional Hazards Models ; Risk Factors ; Sex Factors ; Time Factors</subject><ispartof>Circulation (New York, N.Y.), 1994-03, Vol.89 (3), p.991-997</ispartof><rights>1994 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Mar 1994</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-6511d7252592de30775e951f287f98cb4dacc8d01e5dd6fb931486db49a2d6ce3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4094782$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8124839$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GOLDSCHMID, M. G</creatorcontrib><creatorcontrib>BARRETT-CONNOR, E</creatorcontrib><creatorcontrib>EDELSTEIN, S. L</creatorcontrib><creatorcontrib>WINGARD, D. L</creatorcontrib><creatorcontrib>COHN, B. A</creatorcontrib><creatorcontrib>HERMAN, W. H</creatorcontrib><title>Dyslipidemia and ischemic heart disease mortality among men and women with diabetes</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>We investigated whether the greater increased risk of ischemic heart disease mortality associated with diabetes among women compared with men could be explained by their more pronounced lipoprotein abnormalities.
Seventy-six men and 45 women with diabetes and 327 men and 496 women without diabetes were followed for an average of 16 years in a population-based study. Cox proportional hazards models were used to determine the relative hazard of ischemic heart disease mortality for changes in lipoprotein subfractions after adjustment for age, hypertension, obesity, smoking, exercise, alcohol consumption, and estrogen use (among women). The relative hazard of ischemic heart disease mortality among diabetic women was 1.76 (P = .10) for a 10-mg/dL decrement in high-density lipoprotein cholesterol (HDL-C) and 3.13 (P = .01) for a 1-U increment in log very-low-density lipoprotein cholesterol (VLDL-C). The risk of ischemic heart disease mortality among diabetic women relative to nondiabetic women for an HDL-C level of 50 mg/dL and a log(e) VLDL-C of 3 (about 20 mg/dL) were 4.1 and 3.4, respectively (P < .05). These lipoprotein changes were not associated with ischemic heart disease mortality among men or among nondiabetic women.
Excess ischemic heart disease mortality among diabetic women is partially explained by deleterious levels of HDL-C and VLDL-C. HDL-C levels of < or = 50 mg/dL and VLDL-C levels of > or = 20 mg/dL appear to predict ischemic heart disease mortality among these women and may help identify women who would benefit most from intervention.</description><subject>Associated diseases and complications</subject><subject>Biological and medical sciences</subject><subject>California - epidemiology</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, VLDL - blood</subject><subject>Cohort Studies</subject><subject>Diabetes Mellitus - blood</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Ischemia - mortality</subject><subject>Proportional Hazards Models</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Time Factors</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtLJDEQgIMo7jh69rTQyOKt2zw7yVFmfYEg-DiHdFLtRPoxJj3I_HujDnPwVFXUV0XVh9ApwRUhNbnApFrcPVZKV6zSmuyhGRGUl1wwvY9mGGNdSkbpH3SU0lsuaybFITpUhHLF9Aw9_d-kLqyChz7Ywg6-CMktc-GKJdg4FT4ksAmKfoyT7cK0KWw_Dq9FD8M3_jF-ZR9hWmbUNjBBOkYHre0SnGzjHL1cXz0vbsv7h5u7xeV96TjVU1kLQrykggpNPTAspQAtSEuVbLVyDffWOeUxAeF93TaaEa5q33Btqa8dsDk6_9m7iuP7GtJk-nw8dJ0dYFwnI2uWf1Qqg2e_wLdxHYd8m6GE1kzL7GWOLn4gF8eUIrRmFUNv48YQbL5cG0xMdm2UNsxk13ni73btuunB7_it3Nz_t-3b5GzXRju4kHYYx5pLRdknX9CGSA</recordid><startdate>19940301</startdate><enddate>19940301</enddate><creator>GOLDSCHMID, M. G</creator><creator>BARRETT-CONNOR, E</creator><creator>EDELSTEIN, S. L</creator><creator>WINGARD, D. L</creator><creator>COHN, B. A</creator><creator>HERMAN, W. H</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>19940301</creationdate><title>Dyslipidemia and ischemic heart disease mortality among men and women with diabetes</title><author>GOLDSCHMID, M. G ; BARRETT-CONNOR, E ; EDELSTEIN, S. L ; WINGARD, D. L ; COHN, B. A ; HERMAN, W. H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-6511d7252592de30775e951f287f98cb4dacc8d01e5dd6fb931486db49a2d6ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Associated diseases and complications</topic><topic>Biological and medical sciences</topic><topic>California - epidemiology</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, VLDL - blood</topic><topic>Cohort Studies</topic><topic>Diabetes Mellitus - blood</topic><topic>Diabetes Mellitus - epidemiology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Ischemia - mortality</topic><topic>Proportional Hazards Models</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GOLDSCHMID, M. G</creatorcontrib><creatorcontrib>BARRETT-CONNOR, E</creatorcontrib><creatorcontrib>EDELSTEIN, S. L</creatorcontrib><creatorcontrib>WINGARD, D. L</creatorcontrib><creatorcontrib>COHN, B. A</creatorcontrib><creatorcontrib>HERMAN, W. 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H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dyslipidemia and ischemic heart disease mortality among men and women with diabetes</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>1994-03-01</date><risdate>1994</risdate><volume>89</volume><issue>3</issue><spage>991</spage><epage>997</epage><pages>991-997</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>We investigated whether the greater increased risk of ischemic heart disease mortality associated with diabetes among women compared with men could be explained by their more pronounced lipoprotein abnormalities.
Seventy-six men and 45 women with diabetes and 327 men and 496 women without diabetes were followed for an average of 16 years in a population-based study. Cox proportional hazards models were used to determine the relative hazard of ischemic heart disease mortality for changes in lipoprotein subfractions after adjustment for age, hypertension, obesity, smoking, exercise, alcohol consumption, and estrogen use (among women). The relative hazard of ischemic heart disease mortality among diabetic women was 1.76 (P = .10) for a 10-mg/dL decrement in high-density lipoprotein cholesterol (HDL-C) and 3.13 (P = .01) for a 1-U increment in log very-low-density lipoprotein cholesterol (VLDL-C). The risk of ischemic heart disease mortality among diabetic women relative to nondiabetic women for an HDL-C level of 50 mg/dL and a log(e) VLDL-C of 3 (about 20 mg/dL) were 4.1 and 3.4, respectively (P < .05). These lipoprotein changes were not associated with ischemic heart disease mortality among men or among nondiabetic women.
Excess ischemic heart disease mortality among diabetic women is partially explained by deleterious levels of HDL-C and VLDL-C. HDL-C levels of < or = 50 mg/dL and VLDL-C levels of > or = 20 mg/dL appear to predict ischemic heart disease mortality among these women and may help identify women who would benefit most from intervention.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>8124839</pmid><doi>10.1161/01.CIR.89.3.991</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Associated diseases and complications Biological and medical sciences California - epidemiology Cholesterol, HDL - blood Cholesterol, VLDL - blood Cohort Studies Diabetes Mellitus - blood Diabetes Mellitus - epidemiology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Female Follow-Up Studies Humans Male Medical sciences Middle Aged Myocardial Ischemia - mortality Proportional Hazards Models Risk Factors Sex Factors Time Factors |
| title | Dyslipidemia and ischemic heart disease mortality among men and women with diabetes |
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