DNA and Protein Studies of HLA Class II Molecules: Their Relationship to T Cell Recognition
Great advances have been made in our understanding of this region in recent years utilizing both the tools of molecular genetics and studies of protein encoded by HLA-D genes. A critical bridge that has not yet been completed concerns the relationship of class II genes and protein products to determ...
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| Veröffentlicht in: | Immunological reviews 1985-06, Vol.85 (1), p.129-148 |
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| creator | Segall, Miriam Cairns, J. Scott Dahl, Carol A. Curtsinger, Julie M. Freeman, Scott Nelson, Peter J. Cohen, Oded Wu, Shaokee Nicklas, Janice N. Noreen, Harriet J. Linner, Kristin M. Saunders, Thomas L. Choong, Stephana A. Ohta, Nobuo Reinsmoen, Nancy L. Alter, Barbara J. Bach, Fritz H. |
| description | Great advances have been made in our understanding of this region in recent years utilizing both the tools of molecular genetics and studies of protein encoded by HLA-D genes. A critical bridge that has not yet been completed concerns the relationship of class II genes and protein products to determinants recognized by T-lymphocytes, i.e. the cells responding in MLC. Although the emphasis in this review will be on studies of proteins and of DNA, an introduction to this article also includes the current state of knowledge regarding definition of class II products with I lymphocytes. |
| doi_str_mv | 10.1111/j.1600-065X.1985.tb01133.x |
| format | Article |
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Scott ; Dahl, Carol A. ; Curtsinger, Julie M. ; Freeman, Scott ; Nelson, Peter J. ; Cohen, Oded ; Wu, Shaokee ; Nicklas, Janice N. ; Noreen, Harriet J. ; Linner, Kristin M. ; Saunders, Thomas L. ; Choong, Stephana A. ; Ohta, Nobuo ; Reinsmoen, Nancy L. ; Alter, Barbara J. ; Bach, Fritz H.</creator><creatorcontrib>Segall, Miriam ; Cairns, J. Scott ; Dahl, Carol A. ; Curtsinger, Julie M. ; Freeman, Scott ; Nelson, Peter J. ; Cohen, Oded ; Wu, Shaokee ; Nicklas, Janice N. ; Noreen, Harriet J. ; Linner, Kristin M. ; Saunders, Thomas L. ; Choong, Stephana A. ; Ohta, Nobuo ; Reinsmoen, Nancy L. ; Alter, Barbara J. ; Bach, Fritz H.</creatorcontrib><description>Great advances have been made in our understanding of this region in recent years utilizing both the tools of molecular genetics and studies of protein encoded by HLA-D genes. A critical bridge that has not yet been completed concerns the relationship of class II genes and protein products to determinants recognized by T-lymphocytes, i.e. the cells responding in MLC. 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A critical bridge that has not yet been completed concerns the relationship of class II genes and protein products to determinants recognized by T-lymphocytes, i.e. the cells responding in MLC. Although the emphasis in this review will be on studies of proteins and of DNA, an introduction to this article also includes the current state of knowledge regarding definition of class II products with I lymphocytes.</description><subject>Base Sequence</subject><subject>Clone Cells - immunology</subject><subject>DNA - genetics</subject><subject>Histocompatibility Antigens Class II - classification</subject><subject>Histocompatibility Antigens Class II - genetics</subject><subject>Histocompatibility Antigens Class II - immunology</subject><subject>Histocompatibility Testing</subject><subject>Humans</subject><subject>Isoantibodies - immunology</subject><subject>Phenotype</subject><subject>Polymorphism, Genetic</subject><subject>Protein Conformation</subject><subject>T-Lymphocytes - immunology</subject><issn>0105-2896</issn><issn>1600-065X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkV1v0zAYhS3ENMrgJyBZXHCXzF-J7V0gVYVtFe2GtiKQuLCc-A1zSeMSJ1r370nUqrfTfGPJ57yP7XMQ-khJSod1vk5pTkhC8uxXSrXK0q4glHKe7l6hyVF6jSaEkixhSudv0NsY14RQyZk4Radcaa2pmKDfX26m2DYOf29DB77B913vPEQcKny9mOJZbWPE8zlehhrKvoZ4gVcP4Ft8B7XtfGjig9_iLuAVnkFdD8dl-NP4UXmHTipbR3h_2M_Qj8uvq9l1sri9ms-mi6QUguiEk6piVaHAKQZKShBl5pzkQlvBVOFIqWQmtZaVZLx0mRAw_ENZV_CCSaD8DH3ac7dt-NdD7MzGx3J4jG0g9NHInCvO8_xZIxVCSyb5YLzYG8s2xNhCZbat39j2yVBixgrM2ow5mzFnM1ZgDhWY3TD84XBLX2zAHUcPmQ_6573-6Gt4egHZzJd3lOkBkOwBPnawOwJs-9fkksvM_Ly5Mqvlpebf-L1R_D8PIaQI</recordid><startdate>198506</startdate><enddate>198506</enddate><creator>Segall, Miriam</creator><creator>Cairns, J. 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| fulltext | fulltext |
| identifier | ISSN: 0105-2896 |
| ispartof | Immunological reviews, 1985-06, Vol.85 (1), p.129-148 |
| issn | 0105-2896 1600-065X |
| language | eng |
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| source | MEDLINE; Wiley Journals |
| subjects | Base Sequence Clone Cells - immunology DNA - genetics Histocompatibility Antigens Class II - classification Histocompatibility Antigens Class II - genetics Histocompatibility Antigens Class II - immunology Histocompatibility Testing Humans Isoantibodies - immunology Phenotype Polymorphism, Genetic Protein Conformation T-Lymphocytes - immunology |
| title | DNA and Protein Studies of HLA Class II Molecules: Their Relationship to T Cell Recognition |
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