Detection of C-Type Natriuretic Peptide in Human Circulation and Marked Increase of Plasma CNP Level in Septic Shock Patients
We have previously reported that C-type natriuretic peptide (CNP), the third member of natriuretic family, was produced in vascular endothelial cells and hypothesized that CNP might be a local regulator of vascular tone and/or growth from endothelial cells. In order to clarify the pathophysiological...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1994-02, Vol.198 (3), p.1177-1182 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Hama, N. Itoh, H. Shirakami, G. Suga, S. Komatsu, Y. Yoshimasa, T. Tanaka, I. Mori, K. Nakao, K. |
| description | We have previously reported that C-type natriuretic peptide (CNP), the third member of natriuretic family, was produced in vascular endothelial cells and hypothesized that CNP might be a local regulator of vascular tone and/or growth from endothelial cells. In order to clarify the pathophysiological significance of CNP in humans, we examined the presence of CNP in human circulation and determined plasma levels of CNP in patients with various cardiovascular disorders. The plasma level of CNP in healthy persons was 1.4 ± 0.6 fmol/ml (n=13). The plasma level of CNP was markedly increased in patients with septic shock (13.2 ± 10.1 fmol/ml, n=11), while there was no alteration in patients with congestive heart failure or hypertension. There was two-fold increase of the plasma CNP level in patients with chronic renal failure. These results indicate that CNP, which can be considered as an endothelium-derived relaxing peptide, is detectable in human circulation and suggest the pathophysiological significance of endothelial CNP in humans. |
| doi_str_mv | 10.1006/bbrc.1994.1166 |
| format | Article |
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In order to clarify the pathophysiological significance of CNP in humans, we examined the presence of CNP in human circulation and determined plasma levels of CNP in patients with various cardiovascular disorders. The plasma level of CNP in healthy persons was 1.4 ± 0.6 fmol/ml (n=13). The plasma level of CNP was markedly increased in patients with septic shock (13.2 ± 10.1 fmol/ml, n=11), while there was no alteration in patients with congestive heart failure or hypertension. There was two-fold increase of the plasma CNP level in patients with chronic renal failure. These results indicate that CNP, which can be considered as an endothelium-derived relaxing peptide, is detectable in human circulation and suggest the pathophysiological significance of endothelial CNP in humans.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1006/bbrc.1994.1166</identifier><identifier>PMID: 8117275</identifier><identifier>CODEN: BBRCA9</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Atrial Natriuretic Factor - analysis ; Biological and medical sciences ; Biomarkers - blood ; Chromatography, Gel ; Chromatography, High Pressure Liquid ; Cross Reactions ; Emergency and intensive care: infection, septic shock ; Heart Failure - blood ; Humans ; Hypertension - blood ; Intensive care medicine ; Kidney Failure, Chronic - blood ; Medical sciences ; Middle Aged ; Natriuretic Peptide, Brain ; Natriuretic Peptide, C-Type ; Nerve Tissue Proteins - blood ; Reference Values ; Shock, Septic - blood</subject><ispartof>Biochemical and biophysical research communications, 1994-02, Vol.198 (3), p.1177-1182</ispartof><rights>1994 Academic Press</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-60ba37e80d846d1f652888a175c752932099c24de2eb77fdbae45588e50965263</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006291X84711661$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3949979$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8117275$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hama, N.</creatorcontrib><creatorcontrib>Itoh, H.</creatorcontrib><creatorcontrib>Shirakami, G.</creatorcontrib><creatorcontrib>Suga, S.</creatorcontrib><creatorcontrib>Komatsu, Y.</creatorcontrib><creatorcontrib>Yoshimasa, T.</creatorcontrib><creatorcontrib>Tanaka, I.</creatorcontrib><creatorcontrib>Mori, K.</creatorcontrib><creatorcontrib>Nakao, K.</creatorcontrib><title>Detection of C-Type Natriuretic Peptide in Human Circulation and Marked Increase of Plasma CNP Level in Septic Shock Patients</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>We have previously reported that C-type natriuretic peptide (CNP), the third member of natriuretic family, was produced in vascular endothelial cells and hypothesized that CNP might be a local regulator of vascular tone and/or growth from endothelial cells. In order to clarify the pathophysiological significance of CNP in humans, we examined the presence of CNP in human circulation and determined plasma levels of CNP in patients with various cardiovascular disorders. The plasma level of CNP in healthy persons was 1.4 ± 0.6 fmol/ml (n=13). The plasma level of CNP was markedly increased in patients with septic shock (13.2 ± 10.1 fmol/ml, n=11), while there was no alteration in patients with congestive heart failure or hypertension. There was two-fold increase of the plasma CNP level in patients with chronic renal failure. These results indicate that CNP, which can be considered as an endothelium-derived relaxing peptide, is detectable in human circulation and suggest the pathophysiological significance of endothelial CNP in humans.</description><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Atrial Natriuretic Factor - analysis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Chromatography, Gel</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cross Reactions</subject><subject>Emergency and intensive care: infection, septic shock</subject><subject>Heart Failure - blood</subject><subject>Humans</subject><subject>Hypertension - blood</subject><subject>Intensive care medicine</subject><subject>Kidney Failure, Chronic - blood</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Natriuretic Peptide, Brain</subject><subject>Natriuretic Peptide, C-Type</subject><subject>Nerve Tissue Proteins - blood</subject><subject>Reference Values</subject><subject>Shock, Septic - blood</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kTtPHDEURq2ICBaSNh2SC5RuNrbH40eJJg-QNmQliJTO8th3hGEeiz2DRJH_Hg-7okt1i3u-T1fnIvSJkjUlRHxpmujWVGu-plSId2hFiSYFo4QfoRXJRME0_XOCTlN6IIRSLvQxOlaUSiarFfr7FSZwUxgHPLa4Lu5edoBv7BTDHGEKDm9hNwUPOAz4au7tgOsQ3dzZ14gdPP5p4yN4fD24CDbBUrPtbOotrm-2eAPP0C3h26XH4dv70T3ibY7DMKUP6H1ruwQfD_MM_f7-7a6-Kja_flzXl5vC8ZJPhSCNLSUo4hUXnraiYkopS2XlZMV0yYjWjnEPDBopW99Y4FWlFFREZ1aUZ-jzvncXx6cZ0mT6kBx0nR1gnJORolSMSpXB9R50cUwpQmt2MfQ2vhhKzOLbLL7N4tssvnPg_NA8Nz34N_wgOO8vDnubnO3aaAcX0htWaq611BlTewyyhecA0SSXDTnwIeb3GD-G_13wD0Jcmto</recordid><startdate>19940215</startdate><enddate>19940215</enddate><creator>Hama, N.</creator><creator>Itoh, H.</creator><creator>Shirakami, G.</creator><creator>Suga, S.</creator><creator>Komatsu, Y.</creator><creator>Yoshimasa, T.</creator><creator>Tanaka, I.</creator><creator>Mori, K.</creator><creator>Nakao, K.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940215</creationdate><title>Detection of C-Type Natriuretic Peptide in Human Circulation and Marked Increase of Plasma CNP Level in Septic Shock Patients</title><author>Hama, N. ; Itoh, H. ; Shirakami, G. ; Suga, S. ; Komatsu, Y. ; Yoshimasa, T. ; Tanaka, I. ; Mori, K. ; Nakao, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-60ba37e80d846d1f652888a175c752932099c24de2eb77fdbae45588e50965263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Atrial Natriuretic Factor - analysis</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Chromatography, Gel</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Cross Reactions</topic><topic>Emergency and intensive care: infection, septic shock</topic><topic>Heart Failure - blood</topic><topic>Humans</topic><topic>Hypertension - blood</topic><topic>Intensive care medicine</topic><topic>Kidney Failure, Chronic - blood</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Natriuretic Peptide, Brain</topic><topic>Natriuretic Peptide, C-Type</topic><topic>Nerve Tissue Proteins - blood</topic><topic>Reference Values</topic><topic>Shock, Septic - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hama, N.</creatorcontrib><creatorcontrib>Itoh, H.</creatorcontrib><creatorcontrib>Shirakami, G.</creatorcontrib><creatorcontrib>Suga, S.</creatorcontrib><creatorcontrib>Komatsu, Y.</creatorcontrib><creatorcontrib>Yoshimasa, T.</creatorcontrib><creatorcontrib>Tanaka, I.</creatorcontrib><creatorcontrib>Mori, K.</creatorcontrib><creatorcontrib>Nakao, K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hama, N.</au><au>Itoh, H.</au><au>Shirakami, G.</au><au>Suga, S.</au><au>Komatsu, Y.</au><au>Yoshimasa, T.</au><au>Tanaka, I.</au><au>Mori, K.</au><au>Nakao, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of C-Type Natriuretic Peptide in Human Circulation and Marked Increase of Plasma CNP Level in Septic Shock Patients</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1994-02-15</date><risdate>1994</risdate><volume>198</volume><issue>3</issue><spage>1177</spage><epage>1182</epage><pages>1177-1182</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><coden>BBRCA9</coden><abstract>We have previously reported that C-type natriuretic peptide (CNP), the third member of natriuretic family, was produced in vascular endothelial cells and hypothesized that CNP might be a local regulator of vascular tone and/or growth from endothelial cells. In order to clarify the pathophysiological significance of CNP in humans, we examined the presence of CNP in human circulation and determined plasma levels of CNP in patients with various cardiovascular disorders. The plasma level of CNP in healthy persons was 1.4 ± 0.6 fmol/ml (n=13). The plasma level of CNP was markedly increased in patients with septic shock (13.2 ± 10.1 fmol/ml, n=11), while there was no alteration in patients with congestive heart failure or hypertension. There was two-fold increase of the plasma CNP level in patients with chronic renal failure. These results indicate that CNP, which can be considered as an endothelium-derived relaxing peptide, is detectable in human circulation and suggest the pathophysiological significance of endothelial CNP in humans.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>8117275</pmid><doi>10.1006/bbrc.1994.1166</doi><tpages>6</tpages></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 1994-02, Vol.198 (3), p.1177-1182 |
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| subjects | Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Atrial Natriuretic Factor - analysis Biological and medical sciences Biomarkers - blood Chromatography, Gel Chromatography, High Pressure Liquid Cross Reactions Emergency and intensive care: infection, septic shock Heart Failure - blood Humans Hypertension - blood Intensive care medicine Kidney Failure, Chronic - blood Medical sciences Middle Aged Natriuretic Peptide, Brain Natriuretic Peptide, C-Type Nerve Tissue Proteins - blood Reference Values Shock, Septic - blood |
| title | Detection of C-Type Natriuretic Peptide in Human Circulation and Marked Increase of Plasma CNP Level in Septic Shock Patients |
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