Effects of cytokines on synthesis and function of the hepatic asialoglycoprotein receptor

In this study we have investigated whether cytokines, critical mediators of the immune response, might have a direct effect on the expression and/or function of the human hepatic asialoglycoprotein receptor (ASGPR). Binding and uptake of asialoglycoproteins by the human hepatoma cell line, HepG2, an...

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Veröffentlicht in:	Journal of cellular physiology 1994-03, Vol.158 (3), p.527-534
Hauptverfasser:	Treichel, Ulrich, Paietta, Elisabeth, Poralla, Thomas, Meyer zum Büschenfelde, Karl-Hermann, Stockert, Richard J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Antibody Formation Asialoglycoprotein Receptor Asialoglycoproteins - metabolism Biological and medical sciences Carcinoma, Hepatocellular - chemistry Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - ultrastructure Cytokines - pharmacology Down-Regulation Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Interferon-alpha - pharmacology Interferon-gamma - pharmacology Interleukin-2 - pharmacology Liver Neoplasms - chemistry Liver Neoplasms - pathology Liver Neoplasms - ultrastructure Lymphokines, interleukins ( function, expression) Phosphorylation Receptors, Cell Surface - analysis Receptors, Cell Surface - metabolism Receptors, Cell Surface - physiology Receptors, Interleukin-2 - analysis Regulatory factors and their cellular receptors Time Factors Transcription, Genetic Tumor Cells, Cultured Tumor Necrosis Factor-alpha - pharmacology
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