γ‐glutamyltranspeptidase expression regulates the growth‐inhibitory activity of the anti‐tumor prodrug γ‐L‐glutaminyl‐4‐hydroxy‐3‐iodobenzene

γ‐L‐glutaminyl‐4‐hydroxy‐3‐iodobenzene (I‐GHB), a novel iodinated analog of γ‐L‐glutaminyl‐4‐hydrpxybenzene (GHB), demonstrates greater anti‐tumor activity in human and in murine melanoma cell lines. These phenolic amides are substrates for γ‐glutamyltranspeptidase (GGTP; E.G. 2.3.2.2), a cell‐membr...

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