Acute indomethacin-induced jejunal injury in the rat: Early morphological and biochemical changes

Background/Aims: Gastrointestinal injury induced by nonsteroidal anti-inflammatory drugs includes smooth muscle contraction, endothelial cell injury, and neutrophil infiltration. The aim of this study was to correlate early morphological changes with those in the metabolism of arachidonic acid. Meth...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1994-03, Vol.106 (3), p.567-575
Hauptverfasser:	Nygård, Gunilla, Anthony, Andrew, Piasecki, Christopher, Trevethick, Michael A., Hudson, Mark, Dhillon, Amar P., Pounder, Roy E., Wakefield, Andrew J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Movement Dinoprostone - metabolism Drug toxicity and drugs side effects treatment Indomethacin - pharmacology Jejunum - drug effects Jejunum - metabolism Jejunum - pathology Leukotriene B4 - metabolism Male Medical sciences Neutrophils - physiology Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Thromboxanes - blood Toxicity: digestive system
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