Auer rod-like inclusions in adult common acute lymphoblastic leukemia
We report a case of adult common acute lymphoblastic leukemia, defined by enzyme histochemistry and immunophenotypic analysis, which had rod-shaped cytoplasmic inclusions that on Wright's-stained peripheral blood smear resembled Auer rods. Electron microscopic analysis of a buffy coat preparati...
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| Veröffentlicht in: | Human pathology 1994-02, Vol.25 (2), p.211-214 |
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| container_title | Human pathology |
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| creator | Dunphy, Cherie H. Chung, David Dunphy, Frank R. |
| description | We report a case of adult common acute lymphoblastic leukemia, defined by enzyme histochemistry and immunophenotypic analysis, which had rod-shaped cytoplasmic inclusions that on Wright's-stained peripheral blood smear resembled Auer rods. Electron microscopic analysis of a buffy coat preparation revealed that the inclusions were not characteristic of Auer rods, but rather that they were composed of concentric lamellar structures with no limiting membrane and were closely associated with the nuclear membrane. Therefore, the presence of Auer rod-like inclusions in blasts on a Wright's-stained peripheral blood smear does not preclude a diagnosis of acute lymphoblastic leukemia. |
| doi_str_mv | 10.1016/0046-8177(94)90281-X |
| format | Article |
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Electron microscopic analysis of a buffy coat preparation revealed that the inclusions were not characteristic of Auer rods, but rather that they were composed of concentric lamellar structures with no limiting membrane and were closely associated with the nuclear membrane. Therefore, the presence of Auer rod-like inclusions in blasts on a Wright's-stained peripheral blood smear does not preclude a diagnosis of acute lymphoblastic leukemia.</description><subject>acute lymphoblastic leukemia</subject><subject>Adult</subject><subject>Auer rod-like inclusions</subject><subject>Biological and medical sciences</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematopoietic Stem Cells - ultrastructure</subject><subject>Humans</subject><subject>Inclusion Bodies - ultrastructure</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. 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Myelofibrosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dunphy, Cherie H.</creatorcontrib><creatorcontrib>Chung, David</creatorcontrib><creatorcontrib>Dunphy, Frank R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dunphy, Cherie H.</au><au>Chung, David</au><au>Dunphy, Frank R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Auer rod-like inclusions in adult common acute lymphoblastic leukemia</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>1994-02-01</date><risdate>1994</risdate><volume>25</volume><issue>2</issue><spage>211</spage><epage>214</epage><pages>211-214</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>We report a case of adult common acute lymphoblastic leukemia, defined by enzyme histochemistry and immunophenotypic analysis, which had rod-shaped cytoplasmic inclusions that on Wright's-stained peripheral blood smear resembled Auer rods. 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| subjects | acute lymphoblastic leukemia Adult Auer rod-like inclusions Biological and medical sciences Hematologic and hematopoietic diseases Hematopoietic Stem Cells - ultrastructure Humans Inclusion Bodies - ultrastructure Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology |
| title | Auer rod-like inclusions in adult common acute lymphoblastic leukemia |
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