Intact cell binding properties of cells expressing altered beta-adrenergic receptors

During the course of equilibrium competition binding assays with intact cells, agonists induce conversion of beta-adrenergic receptors (BARs) from a native form with high affinity for agonists to a form with a markedly lower apparent affinity. The roles of receptor internalization, receptor-Gs coupl...

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Veröffentlicht in:	Molecular pharmacology 1994-02, Vol.45 (2), p.255-261
Hauptverfasser:	SI-JIA ZHU, TOEWS, M. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Agonists - metabolism Adrenergic beta-Agonists - pharmacology Adrenergic beta-Antagonists - metabolism Adrenergic beta-Antagonists - pharmacology Animals beta-Adrenergic Receptor Kinases Binding, Competitive Biological and medical sciences Cell Line Cell receptors Cell structures and functions Cricetinae Cricetulus Cyclic AMP-Dependent Protein Kinases - metabolism Fundamental and applied biological sciences. Psychology Isoproterenol - metabolism L Cells (Cell Line) Metoprolol - metabolism Metoprolol - pharmacology Mice Molecular and cellular biology Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine) Mutation Phosphorylation Pindolol - analogs & derivatives Pindolol - metabolism Receptors, Adrenergic, beta - genetics Receptors, Adrenergic, beta - metabolism Transfection
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