Characterization of unique human TCR V beta specificities for a family of streptococcal superantigens represented by rheumatogenic serotypes of M protein

The M protein of Streptococcus pyogenes plays a major role in the virulence of these bacteria. Members of the M protein superfamily are characterized by the presence of tandem segments of repeated amino acid sequences. The NH2-terminal end of the M proteins is a hypervariable region that harbors the...

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Veröffentlicht in:	The Journal of immunology (1950) 1994-02, Vol.152 (4), p.2066-2073
Hauptverfasser:	Watanabe-Ohnishi, R, Aelion, J, LeGros, L, Tomai, MA, Sokurenko, EV, Newton, D, Takahara, J, Irino, S, Rashed, S, Kotb, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antigens, Bacterial Bacterial Outer Membrane Proteins Bacterial Proteins - immunology Base Sequence Biological and medical sciences Carrier Proteins Exotoxins - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Lymphocyte Activation Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Membrane Proteins Molecular Sequence Data Receptors, Antigen, T-Cell, alpha-beta - genetics Receptors, Antigen, T-Cell, alpha-beta - physiology Rheumatic Fever - etiology Sensitivity and Specificity Sequence Alignment Streptococcus - immunology Streptococcus pyogenes Superantigens - immunology T-Lymphocytes - immunology
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