C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2
The activity of the C. elegans gene ced-9 is required to protect cells that normally survive from undergoing programmed cell death. Here we describe the cloning and molecular characterization of this gene. ced-9 is an element of a polycistronic locus that also contains the gene cyt-1, which encodes...
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| Veröffentlicht in: | Cell 1994-02, Vol.76 (4), p.665-676 |
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| creator | Hengartner, Michael O. Horvitz, H.Robert |
| description | The activity of the C. elegans gene
ced-9 is required to protect cells that normally survive from undergoing programmed cell death. Here we describe the cloning and molecular characterization of this gene.
ced-9 is an element of a polycistronic locus that also contains the gene
cyt-1, which encodes a protein similar to cytochrome b
560 of complex II of the mitochondrial respiratory chain.
ced-9 encodes a 280 amino acid protein showing sequence and structural similarities to the mammalian proto-oncogene
bcl-2. Overexpression of
bcl-2 can mimic the protective effect of
ced-9 on C. elegans cell death and can prevent the ectopic cell deaths that occur in
ced-9 loss-of-function mutants. These results suggest that
ced-9 and
bcl-2 are homologs and that the molecular mechanism of programmed cell death has been conserved from nematodes to mammals. |
| doi_str_mv | 10.1016/0092-8674(94)90506-1 |
| format | Article |
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ced-9 is required to protect cells that normally survive from undergoing programmed cell death. Here we describe the cloning and molecular characterization of this gene.
ced-9 is an element of a polycistronic locus that also contains the gene
cyt-1, which encodes a protein similar to cytochrome b
560 of complex II of the mitochondrial respiratory chain.
ced-9 encodes a 280 amino acid protein showing sequence and structural similarities to the mammalian proto-oncogene
bcl-2. Overexpression of
bcl-2 can mimic the protective effect of
ced-9 on C. elegans cell death and can prevent the ectopic cell deaths that occur in
ced-9 loss-of-function mutants. These results suggest that
ced-9 and
bcl-2 are homologs and that the molecular mechanism of programmed cell death has been conserved from nematodes to mammals.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/0092-8674(94)90506-1</identifier><identifier>PMID: 7907274</identifier><identifier>CODEN: CELLB5</identifier><language>eng</language><publisher>Cambridge, MA: Elsevier Inc</publisher><subject>Ageing, cell death ; Amino Acid Sequence ; Animals ; Animals, Genetically Modified ; Apoptosis ; Base Sequence ; Biological and medical sciences ; Caenorhabditis - genetics ; Caenorhabditis elegans ; Caenorhabditis elegans - genetics ; Caenorhabditis elegans - growth & development ; Cell physiology ; Cell Survival ; Cloning, Molecular ; Consensus Sequence ; DNA Primers - chemistry ; Fundamental and applied biological sciences. Psychology ; Gene Expression ; Genes, Helminth ; Molecular and cellular biology ; Molecular Sequence Data ; Polymorphism, Restriction Fragment Length ; Proto-Oncogene Proteins - genetics ; Proto-Oncogene Proteins c-bcl-2 ; Restriction Mapping ; RNA, Messenger - genetics ; Sequence Alignment ; Sequence Homology, Amino Acid</subject><ispartof>Cell, 1994-02, Vol.76 (4), p.665-676</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-a2ba84f770235b20cecfd4abfb0d21f0eb9f7cbbe4b9451b713b623a73bd21f3</citedby><cites>FETCH-LOGICAL-c332t-a2ba84f770235b20cecfd4abfb0d21f0eb9f7cbbe4b9451b713b623a73bd21f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0092-8674(94)90506-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3944050$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7907274$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hengartner, Michael O.</creatorcontrib><creatorcontrib>Horvitz, H.Robert</creatorcontrib><title>C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2</title><title>Cell</title><addtitle>Cell</addtitle><description>The activity of the C. elegans gene
ced-9 is required to protect cells that normally survive from undergoing programmed cell death. Here we describe the cloning and molecular characterization of this gene.
ced-9 is an element of a polycistronic locus that also contains the gene
cyt-1, which encodes a protein similar to cytochrome b
560 of complex II of the mitochondrial respiratory chain.
ced-9 encodes a 280 amino acid protein showing sequence and structural similarities to the mammalian proto-oncogene
bcl-2. Overexpression of
bcl-2 can mimic the protective effect of
ced-9 on C. elegans cell death and can prevent the ectopic cell deaths that occur in
ced-9 loss-of-function mutants. These results suggest that
ced-9 and
bcl-2 are homologs and that the molecular mechanism of programmed cell death has been conserved from nematodes to mammals.</description><subject>Ageing, cell death</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Animals, Genetically Modified</subject><subject>Apoptosis</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Caenorhabditis - genetics</subject><subject>Caenorhabditis elegans</subject><subject>Caenorhabditis elegans - genetics</subject><subject>Caenorhabditis elegans - growth & development</subject><subject>Cell physiology</subject><subject>Cell Survival</subject><subject>Cloning, Molecular</subject><subject>Consensus Sequence</subject><subject>DNA Primers - chemistry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression</subject><subject>Genes, Helminth</subject><subject>Molecular and cellular biology</subject><subject>Molecular Sequence Data</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Proto-Oncogene Proteins - genetics</subject><subject>Proto-Oncogene Proteins c-bcl-2</subject><subject>Restriction Mapping</subject><subject>RNA, Messenger - genetics</subject><subject>Sequence Alignment</subject><subject>Sequence Homology, Amino Acid</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuLFDEUhYMoYzv6DxSyENFFxryqUtkMSOMLBtzMPiSpm55IqjImVQ3-e1N200uFQCDnu4ebcxB6zegNo6z_SKnmZOiVfK_lB0072hP2BO0Y1YpIpvhTtLsgz9GLWn9SSoeu667QldJUcSV3KOxvMCQ42LliDynhupZjPNqEDzBDexqJxjD7PELFFod19kvMc9Mf8pRTPuAc8PIAeLLTZFO0M34seckkt5m_Fs4nwl-iZ8GmCq_O9zW6__L5fv-N3P34-n3_6Y54IfhCLHd2kEEpykXnOPXgwyitC46OnAUKTgflnQPptOyYU0y4ngurhNt0cY3enWzbDr9WqIuZYt2-ZWfIazWqF2roBvFfkPWDZFz3DZQn0Jdca4FgHkucbPltGDVbDWbL2GwZG93OVoNhbezN2X91E4yXoXPuTX971m31NoViZx_rBRNayubUsNsTBi2zY4Riqo-tDRhjAb-YMcd_7_EHkHejuA</recordid><startdate>19940225</startdate><enddate>19940225</enddate><creator>Hengartner, Michael O.</creator><creator>Horvitz, H.Robert</creator><general>Elsevier Inc</general><general>Cell Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19940225</creationdate><title>C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2</title><author>Hengartner, Michael O. ; Horvitz, H.Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-a2ba84f770235b20cecfd4abfb0d21f0eb9f7cbbe4b9451b713b623a73bd21f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Ageing, cell death</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Animals, Genetically Modified</topic><topic>Apoptosis</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Caenorhabditis - genetics</topic><topic>Caenorhabditis elegans</topic><topic>Caenorhabditis elegans - genetics</topic><topic>Caenorhabditis elegans - growth & development</topic><topic>Cell physiology</topic><topic>Cell Survival</topic><topic>Cloning, Molecular</topic><topic>Consensus Sequence</topic><topic>DNA Primers - chemistry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression</topic><topic>Genes, Helminth</topic><topic>Molecular and cellular biology</topic><topic>Molecular Sequence Data</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Proto-Oncogene Proteins - genetics</topic><topic>Proto-Oncogene Proteins c-bcl-2</topic><topic>Restriction Mapping</topic><topic>RNA, Messenger - genetics</topic><topic>Sequence Alignment</topic><topic>Sequence Homology, Amino Acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hengartner, Michael O.</creatorcontrib><creatorcontrib>Horvitz, H.Robert</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hengartner, Michael O.</au><au>Horvitz, H.Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>1994-02-25</date><risdate>1994</risdate><volume>76</volume><issue>4</issue><spage>665</spage><epage>676</epage><pages>665-676</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><coden>CELLB5</coden><abstract>The activity of the C. elegans gene
ced-9 is required to protect cells that normally survive from undergoing programmed cell death. Here we describe the cloning and molecular characterization of this gene.
ced-9 is an element of a polycistronic locus that also contains the gene
cyt-1, which encodes a protein similar to cytochrome b
560 of complex II of the mitochondrial respiratory chain.
ced-9 encodes a 280 amino acid protein showing sequence and structural similarities to the mammalian proto-oncogene
bcl-2. Overexpression of
bcl-2 can mimic the protective effect of
ced-9 on C. elegans cell death and can prevent the ectopic cell deaths that occur in
ced-9 loss-of-function mutants. These results suggest that
ced-9 and
bcl-2 are homologs and that the molecular mechanism of programmed cell death has been conserved from nematodes to mammals.</abstract><cop>Cambridge, MA</cop><pub>Elsevier Inc</pub><pmid>7907274</pmid><doi>10.1016/0092-8674(94)90506-1</doi><tpages>12</tpages></addata></record> |
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| ispartof | Cell, 1994-02, Vol.76 (4), p.665-676 |
| issn | 0092-8674 1097-4172 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Ageing, cell death Amino Acid Sequence Animals Animals, Genetically Modified Apoptosis Base Sequence Biological and medical sciences Caenorhabditis - genetics Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - growth & development Cell physiology Cell Survival Cloning, Molecular Consensus Sequence DNA Primers - chemistry Fundamental and applied biological sciences. Psychology Gene Expression Genes, Helminth Molecular and cellular biology Molecular Sequence Data Polymorphism, Restriction Fragment Length Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-bcl-2 Restriction Mapping RNA, Messenger - genetics Sequence Alignment Sequence Homology, Amino Acid |
| title | C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2 |
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