Inhibition of interferon-γ-induced major histocompatibility complex class I expression by certain oligodeoxynucleotides
We report that certain oligonucleotides are capable of inhibiting cell surface induction of the major histocompatibility complex class I (MHC-I) proteins by interferon-gamma in K562 cells. The inhibition by oligodeoxy-nucleotide I 5' GGG GTT GGT TGT GTT GGG TGT TGT GT-RNH2 is dose-dependent, wi...
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| Veröffentlicht in: | Transplantation 1994-02, Vol.57 (4), p.612-615 |
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| container_title | Transplantation |
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| creator | MURALI RAMANATHAN LANTZ, M MACGREGOR, R. D BING HUEY TAM, S YING LI GAROVOY, M. R HUNT, C. A |
| description | We report that certain oligonucleotides are capable of inhibiting cell surface induction of the major histocompatibility complex class I (MHC-I) proteins by interferon-gamma in K562 cells. The inhibition by oligodeoxy-nucleotide I 5' GGG GTT GGT TGT GTT GGG TGT TGT GT-RNH2 is dose-dependent, with an EC50 24 hr after dosing of approximately 4 microM for 800 U/ml interferon-gamma. The reverse complement II 5' AC ACA ACA CCC AAC ACA ACC AAC CCC-RNH2 did not show activity. Oligodeoxynucleotide I inhibits induction of MHC-I by interferon-gamma, but does not inhibit induction by either interferon-alpha or interferon-beta. Four other oligodeoxynucleotides were also evaluated, and three showed activity against interferon-gamma at 25 microM. |
| doi_str_mv | 10.1097/00007890-199402270-00023 |
| format | Article |
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D ; BING HUEY ; TAM, S ; YING LI ; GAROVOY, M. R ; HUNT, C. A</creator><creatorcontrib>MURALI RAMANATHAN ; LANTZ, M ; MACGREGOR, R. D ; BING HUEY ; TAM, S ; YING LI ; GAROVOY, M. R ; HUNT, C. A</creatorcontrib><description>We report that certain oligonucleotides are capable of inhibiting cell surface induction of the major histocompatibility complex class I (MHC-I) proteins by interferon-gamma in K562 cells. The inhibition by oligodeoxy-nucleotide I 5' GGG GTT GGT TGT GTT GGG TGT TGT GT-RNH2 is dose-dependent, with an EC50 24 hr after dosing of approximately 4 microM for 800 U/ml interferon-gamma. The reverse complement II 5' AC ACA ACA CCC AAC ACA ACC AAC CCC-RNH2 did not show activity. Oligodeoxynucleotide I inhibits induction of MHC-I by interferon-gamma, but does not inhibit induction by either interferon-alpha or interferon-beta. Four other oligodeoxynucleotides were also evaluated, and three showed activity against interferon-gamma at 25 microM.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/00007890-199402270-00023</identifier><identifier>PMID: 7906905</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Base Sequence ; Biological and medical sciences ; Cell Adhesion Molecules - genetics ; Cell Line ; Gene Expression - drug effects ; Genes, MHC Class I ; Histocompatibility Antigens Class I - genetics ; Histocompatibility Antigens Class I - metabolism ; Humans ; Immunomodulators ; In Vitro Techniques ; Intercellular Adhesion Molecule-1 ; Interferon-gamma - antagonists & inhibitors ; Medical sciences ; Molecular Sequence Data ; Oligodeoxyribonucleotides - chemistry ; Oligodeoxyribonucleotides - pharmacology ; Pharmacology. Drug treatments ; Promoter Regions, Genetic ; Receptors, Transferrin - metabolism ; RNA, Messenger - genetics</subject><ispartof>Transplantation, 1994-02, Vol.57 (4), p.612-615</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-b65d4c6b52516052b7906c2d93892fc85ddc3c8d5ca61154288b1ff99549713a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,23930,23931,25140,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3956615$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7906905$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MURALI RAMANATHAN</creatorcontrib><creatorcontrib>LANTZ, M</creatorcontrib><creatorcontrib>MACGREGOR, R. D</creatorcontrib><creatorcontrib>BING HUEY</creatorcontrib><creatorcontrib>TAM, S</creatorcontrib><creatorcontrib>YING LI</creatorcontrib><creatorcontrib>GAROVOY, M. R</creatorcontrib><creatorcontrib>HUNT, C. A</creatorcontrib><title>Inhibition of interferon-γ-induced major histocompatibility complex class I expression by certain oligodeoxynucleotides</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>We report that certain oligonucleotides are capable of inhibiting cell surface induction of the major histocompatibility complex class I (MHC-I) proteins by interferon-gamma in K562 cells. The inhibition by oligodeoxy-nucleotide I 5' GGG GTT GGT TGT GTT GGG TGT TGT GT-RNH2 is dose-dependent, with an EC50 24 hr after dosing of approximately 4 microM for 800 U/ml interferon-gamma. The reverse complement II 5' AC ACA ACA CCC AAC ACA ACC AAC CCC-RNH2 did not show activity. Oligodeoxynucleotide I inhibits induction of MHC-I by interferon-gamma, but does not inhibit induction by either interferon-alpha or interferon-beta. Four other oligodeoxynucleotides were also evaluated, and three showed activity against interferon-gamma at 25 microM.</description><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cell Adhesion Molecules - genetics</subject><subject>Cell Line</subject><subject>Gene Expression - drug effects</subject><subject>Genes, MHC Class I</subject><subject>Histocompatibility Antigens Class I - genetics</subject><subject>Histocompatibility Antigens Class I - metabolism</subject><subject>Humans</subject><subject>Immunomodulators</subject><subject>In Vitro Techniques</subject><subject>Intercellular Adhesion Molecule-1</subject><subject>Interferon-gamma - antagonists & inhibitors</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Oligodeoxyribonucleotides - chemistry</subject><subject>Oligodeoxyribonucleotides - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Promoter Regions, Genetic</subject><subject>Receptors, Transferrin - metabolism</subject><subject>RNA, Messenger - genetics</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtuGyEYx1HVKHGcHqESi6o7Uh7Da1lFSWopUjfNesQAkxAxgwOMZJ8r9-iZihvX27JB8H98iB8AkOBrgrX8htuSSmNEtO4wpRKjdkPZB7AinHVIYIU_ghXGHUGEMXkBLkt5aRbOpDwH51JjoTFfgd1mfg5DqCHNMI0wzNXn0ec0o99vKMxusd7BybykDJ9DqcmmaWtqS8RQ9_Bwin4HbTSlwA30u232pRzKhqb6XE1ovTE8JefTbj8vNvpUg_PlCpyNJhb_6bivwePd7a-bH-jh5_3m5vsDsp3GFQ2Cu86KgVNOBOZ0OLzcUqeZ0nS0ijtnmVWOWyMI4R1VaiDjqDXvtCTMsDX4-t67zel18aX2UyjWx2hmn5bSS8Gkwu2P_mckQmGqKG1G9W60OZWS_dhvc5hM3vcE9wc6_T86_YlO_5dOi34-zliGybtT8Iij6V-OuinWxDGb2YZysjHNhWh8_wB1-poh</recordid><startdate>19940227</startdate><enddate>19940227</enddate><creator>MURALI RAMANATHAN</creator><creator>LANTZ, M</creator><creator>MACGREGOR, R. 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A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-b65d4c6b52516052b7906c2d93892fc85ddc3c8d5ca61154288b1ff99549713a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Cell Adhesion Molecules - genetics</topic><topic>Cell Line</topic><topic>Gene Expression - drug effects</topic><topic>Genes, MHC Class I</topic><topic>Histocompatibility Antigens Class I - genetics</topic><topic>Histocompatibility Antigens Class I - metabolism</topic><topic>Humans</topic><topic>Immunomodulators</topic><topic>In Vitro Techniques</topic><topic>Intercellular Adhesion Molecule-1</topic><topic>Interferon-gamma - antagonists & inhibitors</topic><topic>Medical sciences</topic><topic>Molecular Sequence Data</topic><topic>Oligodeoxyribonucleotides - chemistry</topic><topic>Oligodeoxyribonucleotides - pharmacology</topic><topic>Pharmacology. 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A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of interferon-γ-induced major histocompatibility complex class I expression by certain oligodeoxynucleotides</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>1994-02-27</date><risdate>1994</risdate><volume>57</volume><issue>4</issue><spage>612</spage><epage>615</epage><pages>612-615</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>We report that certain oligonucleotides are capable of inhibiting cell surface induction of the major histocompatibility complex class I (MHC-I) proteins by interferon-gamma in K562 cells. The inhibition by oligodeoxy-nucleotide I 5' GGG GTT GGT TGT GTT GGG TGT TGT GT-RNH2 is dose-dependent, with an EC50 24 hr after dosing of approximately 4 microM for 800 U/ml interferon-gamma. The reverse complement II 5' AC ACA ACA CCC AAC ACA ACC AAC CCC-RNH2 did not show activity. Oligodeoxynucleotide I inhibits induction of MHC-I by interferon-gamma, but does not inhibit induction by either interferon-alpha or interferon-beta. Four other oligodeoxynucleotides were also evaluated, and three showed activity against interferon-gamma at 25 microM.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>7906905</pmid><doi>10.1097/00007890-199402270-00023</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Transplantation, 1994-02, Vol.57 (4), p.612-615 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Base Sequence Biological and medical sciences Cell Adhesion Molecules - genetics Cell Line Gene Expression - drug effects Genes, MHC Class I Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - metabolism Humans Immunomodulators In Vitro Techniques Intercellular Adhesion Molecule-1 Interferon-gamma - antagonists & inhibitors Medical sciences Molecular Sequence Data Oligodeoxyribonucleotides - chemistry Oligodeoxyribonucleotides - pharmacology Pharmacology. Drug treatments Promoter Regions, Genetic Receptors, Transferrin - metabolism RNA, Messenger - genetics |
| title | Inhibition of interferon-γ-induced major histocompatibility complex class I expression by certain oligodeoxynucleotides |
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