Pyrido[2,3-d]pyrimidine Angiotensin II Antagonists

A series of pyrido[2,3-d]pyrimidine angiotensin II (A II) antagonists was synthesized and tested for antagonism of A II. Compounds with a biphenylyltetrazole pharmacophore and small alkyl groups at the 2- and 4-positions of the pyridopyrimidine ring were found to be the most potent in an AT1 recepto...

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Veröffentlicht in:	Journal of medicinal chemistry 1994-02, Vol.37 (4), p.542-550
Hauptverfasser:	Ellingboe, John W, Antane, Madelene, Nguyen, Thomas T, Collini, Michael D, Antane, Schuyler, Bender, Reinhold, Hartupee, Dale, White, Valerie, McCallum, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Pressure - drug effects Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Liver - drug effects Liver - metabolism Male Organic chemistry Preparations and properties Pressoreceptors - drug effects Pyridines - chemical synthesis Pyridines - pharmacokinetics Pyridines - pharmacology Pyrimidines - chemical synthesis Pyrimidines - pharmacokinetics Pyrimidines - pharmacology Rats Rats, Sprague-Dawley Structure-Activity Relationship Tetrazoles - chemical synthesis Tetrazoles - pharmacokinetics Tetrazoles - pharmacology
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