Endothelin-1 promotes mitogenesis in airway smooth muscle cells

Endothelin exists as three isoforms (ET-1, ET-2, and ET-3) and exhibits vasoconstricting, bronchoconstricting, and growth-promoting properties in vascular smooth muscle. In the airways, ET-1 immunoreactivity and mRNA have been detected and localized to the epithelium, smooth muscle, and endothelium...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 1994-03, Vol.10 (3), p.316-321
Hauptverfasser:	Glassberg, MK, Ergul, A, Wanner, A, Puett, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Biological and medical sciences Cell Division - drug effects Cell physiology Cells, Cultured Endothelins - metabolism Endothelins - pharmacology Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Genes, fos Hormonal regulation Mitogens - pharmacology Molecular and cellular biology Muscle, Smooth - cytology Muscle, Smooth - drug effects Muscle, Smooth - metabolism RNA, Messenger - metabolism Sheep Staining and Labeling Trachea - cytology Trachea - drug effects Trachea - metabolism
Online-Zugang:	Volltext
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