Fetal Weight at Term Influenced by H-2-Associated Loci
Abstract Pregnant mice which in theory differ only in the region of the major histocompatibility complex (MHC) on chromosome 17 (C57BL/10, the inbred partner [host strain], and B10.D2, B10.BR, B10.A, B10.A[2R], B10.A[5R], B10.A[15R] and B10.A[18R]) were sacrificed on the 11th and 18th days of gestat...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1994-01, Vol.205 (1), p.85-88 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
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| creator | Tyan, Marvin L. |
| description | Abstract
Pregnant mice which in theory differ only in the region of the major histocompatibility complex (MHC) on chromosome 17 (C57BL/10, the inbred partner [host strain], and B10.D2, B10.BR, B10.A, B10.A[2R], B10.A[5R], B10.A[15R] and B10.A[18R]) were sacrificed on the 11th and 18th days of gestation, and the fetuses were sexed and weighed. Fetuses from reciprocal crosses between B10.A and B10.BR, B10.D2 and C57BL/10 were weighed and sexed on the 18th day of gestation. It was found that (i) fetal weights were not significantly different among the strains examined on day 11 (B10.BR, B10.A[15R] and B10.A[18R]), (ii) B10.BR fetuses of both sexes weighed significantly less than fetuses from the other strains on day 18, (iii) B10.D2 18-day-old male but not female fetuses were heavier than the males from the other strains (this difference was not present when corrections for litter size were made), (iv) the fetuses from the B10.A x B10.BR cross were the smallest, those from the B10.D2 x B10.A cross the largest, and those from the B10.A x C57BL/10 crosses intermediate, and (v) maternal effects were noted in the B10.A x B10.BR and B10.A x B10.D2 but not the B10.A x C57BL/10 crosses. The results suggest that there are two or more MHC associated loci that influence growth rate in late gestation. Among the candidate genes are Ped and Igfr II. |
| doi_str_mv | 10.3181/00379727-205-43682 |
| format | Article |
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Pregnant mice which in theory differ only in the region of the major histocompatibility complex (MHC) on chromosome 17 (C57BL/10, the inbred partner [host strain], and B10.D2, B10.BR, B10.A, B10.A[2R], B10.A[5R], B10.A[15R] and B10.A[18R]) were sacrificed on the 11th and 18th days of gestation, and the fetuses were sexed and weighed. Fetuses from reciprocal crosses between B10.A and B10.BR, B10.D2 and C57BL/10 were weighed and sexed on the 18th day of gestation. It was found that (i) fetal weights were not significantly different among the strains examined on day 11 (B10.BR, B10.A[15R] and B10.A[18R]), (ii) B10.BR fetuses of both sexes weighed significantly less than fetuses from the other strains on day 18, (iii) B10.D2 18-day-old male but not female fetuses were heavier than the males from the other strains (this difference was not present when corrections for litter size were made), (iv) the fetuses from the B10.A x B10.BR cross were the smallest, those from the B10.D2 x B10.A cross the largest, and those from the B10.A x C57BL/10 crosses intermediate, and (v) maternal effects were noted in the B10.A x B10.BR and B10.A x B10.D2 but not the B10.A x C57BL/10 crosses. The results suggest that there are two or more MHC associated loci that influence growth rate in late gestation. Among the candidate genes are Ped and Igfr II.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-205-43682</identifier><identifier>PMID: 8115355</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Alleles ; Animals ; BIOLOGY AND MEDICINE, BASIC STUDIES ; Body Weight - immunology ; Chromosome Mapping ; CHROMOSOMES ; Female ; Fetus - anatomy & histology ; FETUSES ; GENES ; GENETIC MAPPING ; Gestational Age ; H-2 Antigens - genetics ; HISTOCOMPATIBILITY COMPLEX ; HUMAN CHROMOSOME 17 ; Litter Size ; Male ; MICE ; Mice, Inbred C57BL ; Mice, Inbred Strains ; ONTOGENESIS ; Pregnancy ; WEIGHT</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1994-01, Vol.205 (1), p.85-88</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,885,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8115355$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/283144$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Tyan, Marvin L.</creatorcontrib><title>Fetal Weight at Term Influenced by H-2-Associated Loci</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Abstract
Pregnant mice which in theory differ only in the region of the major histocompatibility complex (MHC) on chromosome 17 (C57BL/10, the inbred partner [host strain], and B10.D2, B10.BR, B10.A, B10.A[2R], B10.A[5R], B10.A[15R] and B10.A[18R]) were sacrificed on the 11th and 18th days of gestation, and the fetuses were sexed and weighed. Fetuses from reciprocal crosses between B10.A and B10.BR, B10.D2 and C57BL/10 were weighed and sexed on the 18th day of gestation. It was found that (i) fetal weights were not significantly different among the strains examined on day 11 (B10.BR, B10.A[15R] and B10.A[18R]), (ii) B10.BR fetuses of both sexes weighed significantly less than fetuses from the other strains on day 18, (iii) B10.D2 18-day-old male but not female fetuses were heavier than the males from the other strains (this difference was not present when corrections for litter size were made), (iv) the fetuses from the B10.A x B10.BR cross were the smallest, those from the B10.D2 x B10.A cross the largest, and those from the B10.A x C57BL/10 crosses intermediate, and (v) maternal effects were noted in the B10.A x B10.BR and B10.A x B10.D2 but not the B10.A x C57BL/10 crosses. The results suggest that there are two or more MHC associated loci that influence growth rate in late gestation. Among the candidate genes are Ped and Igfr II.</description><subject>Alleles</subject><subject>Animals</subject><subject>BIOLOGY AND MEDICINE, BASIC STUDIES</subject><subject>Body Weight - immunology</subject><subject>Chromosome Mapping</subject><subject>CHROMOSOMES</subject><subject>Female</subject><subject>Fetus - anatomy & histology</subject><subject>FETUSES</subject><subject>GENES</subject><subject>GENETIC MAPPING</subject><subject>Gestational Age</subject><subject>H-2 Antigens - genetics</subject><subject>HISTOCOMPATIBILITY COMPLEX</subject><subject>HUMAN CHROMOSOME 17</subject><subject>Litter Size</subject><subject>Male</subject><subject>MICE</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred Strains</subject><subject>ONTOGENESIS</subject><subject>Pregnancy</subject><subject>WEIGHT</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi0EKqXwB5CQwsJm6o_YScaqohSpEksRo2U7lzZVPkrsDP33OKQwMt3p3ufe4UHonpJnTlM6J4QnWcISzIjAMZcpu0BTKrjAXGbZJZoOAB6Ia3Tj3IEQKhImJ2iS0gETUyRX4HUVfUK52_tI-2gLXR29NUXVQ2Mhj8wpWmOGF861ttQ-XDZhuUVXha4c3J3nDH2sXrbLNd68v74tFxtsORUeZ7nhtIhJZtI0TxkIIxk3RLMcuOBpYmKZsyKnoIvMQmZsbFkhmMmllNpKzmfocextnS-Vs6UHu7dt04D1iqWcxnFgnkbm2LVfPTiv6tJZqCrdQNs7lUie8ISSALIRtF3rXAeFOnZlrbuTokQNQtWvUBWEqh-h4enh3N6bGvK_l7PBkM_H3OkdqEPbd00Q8l_jN1L2e_4</recordid><startdate>199401</startdate><enddate>199401</enddate><creator>Tyan, Marvin L.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>199401</creationdate><title>Fetal Weight at Term Influenced by H-2-Associated Loci</title><author>Tyan, Marvin L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c315t-9db31f409b88d82e5b623b0a2de35387b46d2fd1eaf9ce9bc4c2f52bd666ac633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Alleles</topic><topic>Animals</topic><topic>BIOLOGY AND MEDICINE, BASIC STUDIES</topic><topic>Body Weight - immunology</topic><topic>Chromosome Mapping</topic><topic>CHROMOSOMES</topic><topic>Female</topic><topic>Fetus - anatomy & histology</topic><topic>FETUSES</topic><topic>GENES</topic><topic>GENETIC MAPPING</topic><topic>Gestational Age</topic><topic>H-2 Antigens - genetics</topic><topic>HISTOCOMPATIBILITY COMPLEX</topic><topic>HUMAN CHROMOSOME 17</topic><topic>Litter Size</topic><topic>Male</topic><topic>MICE</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred Strains</topic><topic>ONTOGENESIS</topic><topic>Pregnancy</topic><topic>WEIGHT</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tyan, Marvin L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tyan, Marvin L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fetal Weight at Term Influenced by H-2-Associated Loci</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1994-01</date><risdate>1994</risdate><volume>205</volume><issue>1</issue><spage>85</spage><epage>88</epage><pages>85-88</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Abstract
Pregnant mice which in theory differ only in the region of the major histocompatibility complex (MHC) on chromosome 17 (C57BL/10, the inbred partner [host strain], and B10.D2, B10.BR, B10.A, B10.A[2R], B10.A[5R], B10.A[15R] and B10.A[18R]) were sacrificed on the 11th and 18th days of gestation, and the fetuses were sexed and weighed. Fetuses from reciprocal crosses between B10.A and B10.BR, B10.D2 and C57BL/10 were weighed and sexed on the 18th day of gestation. It was found that (i) fetal weights were not significantly different among the strains examined on day 11 (B10.BR, B10.A[15R] and B10.A[18R]), (ii) B10.BR fetuses of both sexes weighed significantly less than fetuses from the other strains on day 18, (iii) B10.D2 18-day-old male but not female fetuses were heavier than the males from the other strains (this difference was not present when corrections for litter size were made), (iv) the fetuses from the B10.A x B10.BR cross were the smallest, those from the B10.D2 x B10.A cross the largest, and those from the B10.A x C57BL/10 crosses intermediate, and (v) maternal effects were noted in the B10.A x B10.BR and B10.A x B10.D2 but not the B10.A x C57BL/10 crosses. The results suggest that there are two or more MHC associated loci that influence growth rate in late gestation. Among the candidate genes are Ped and Igfr II.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>8115355</pmid><doi>10.3181/00379727-205-43682</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Alleles Animals BIOLOGY AND MEDICINE, BASIC STUDIES Body Weight - immunology Chromosome Mapping CHROMOSOMES Female Fetus - anatomy & histology FETUSES GENES GENETIC MAPPING Gestational Age H-2 Antigens - genetics HISTOCOMPATIBILITY COMPLEX HUMAN CHROMOSOME 17 Litter Size Male MICE Mice, Inbred C57BL Mice, Inbred Strains ONTOGENESIS Pregnancy WEIGHT |
| title | Fetal Weight at Term Influenced by H-2-Associated Loci |
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