Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion
The number of neurotrophic factors found in the central nervous system is rapidly growing, but their functions in vivo are largely unknown. In the peripheral nervous system they promote the survival of developing and lesioned neurons and enhance nerve fibre growth and regeneration. Here we study the...
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| Veröffentlicht in: | Nature (London) 1994-01, Vol.367 (6459), p.170-173 |
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| creator | Schnell, Lisa Schneider, Regula Kolbeck, Roland Barde, Yves-Alain Schwab, Martin E |
| description | The number of neurotrophic factors found in the central nervous system is rapidly growing, but their functions in vivo are largely unknown. In the peripheral nervous system they promote the survival of developing and lesioned neurons and enhance nerve fibre growth and regeneration. Here we study the effects of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) on the largest tract system leading from the brain to the spinal cord, the corticospinal tract (CST). The developing CST grows down the spinal cord during the first postnatal days and innervates its targets after a waiting period by collateral sprouting. We find that NT-3 injected locally specifically enhances this sprouting, whereas BDNF has no effect. In adult rats, injection of NT-3 (but not BDNF) into the lesioned spinal cord increases the regenerative sprouting of the transected CST. The distance of growth of the sprouts is very restricted, but application of an antibody that neutralizes myelin-associated neurite growth inhibitory proteins results in long-distance regeneration of CST fibres. |
| doi_str_mv | 10.1038/367170a0 |
| format | Article |
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In the peripheral nervous system they promote the survival of developing and lesioned neurons and enhance nerve fibre growth and regeneration. Here we study the effects of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) on the largest tract system leading from the brain to the spinal cord, the corticospinal tract (CST). The developing CST grows down the spinal cord during the first postnatal days and innervates its targets after a waiting period by collateral sprouting. We find that NT-3 injected locally specifically enhances this sprouting, whereas BDNF has no effect. In adult rats, injection of NT-3 (but not BDNF) into the lesioned spinal cord increases the regenerative sprouting of the transected CST. The distance of growth of the sprouts is very restricted, but application of an antibody that neutralizes myelin-associated neurite growth inhibitory proteins results in long-distance regeneration of CST fibres.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/367170a0</identifier><identifier>PMID: 8114912</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing</publisher><subject>Animals ; Animals, Newborn ; Biological and medical sciences ; Brain-Derived Neurotrophic Factor ; Development. Senescence. Regeneration. Transplantation ; Fundamental and applied biological sciences. Psychology ; Nerve Growth Factors - pharmacology ; Nerve Regeneration - drug effects ; Nerve Tissue Proteins - pharmacology ; Neurology ; Neurotrophin 3 ; Physical growth ; Pyramidal Tracts - drug effects ; Pyramidal Tracts - growth & development ; Rats ; Rats, Inbred Lew ; Spinal Cord Injuries - drug therapy ; Spinal Cord Injuries - physiopathology ; Spine ; Vertebrates: nervous system and sense organs</subject><ispartof>Nature (London), 1994-01, Vol.367 (6459), p.170-173</ispartof><rights>1994 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. 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In the peripheral nervous system they promote the survival of developing and lesioned neurons and enhance nerve fibre growth and regeneration. Here we study the effects of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) on the largest tract system leading from the brain to the spinal cord, the corticospinal tract (CST). The developing CST grows down the spinal cord during the first postnatal days and innervates its targets after a waiting period by collateral sprouting. We find that NT-3 injected locally specifically enhances this sprouting, whereas BDNF has no effect. In adult rats, injection of NT-3 (but not BDNF) into the lesioned spinal cord increases the regenerative sprouting of the transected CST. 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Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schnell, Lisa</au><au>Schneider, Regula</au><au>Kolbeck, Roland</au><au>Barde, Yves-Alain</au><au>Schwab, Martin E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion</atitle><jtitle>Nature (London)</jtitle><addtitle>Nature</addtitle><date>1994-01-13</date><risdate>1994</risdate><volume>367</volume><issue>6459</issue><spage>170</spage><epage>173</epage><pages>170-173</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>The number of neurotrophic factors found in the central nervous system is rapidly growing, but their functions in vivo are largely unknown. In the peripheral nervous system they promote the survival of developing and lesioned neurons and enhance nerve fibre growth and regeneration. Here we study the effects of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) on the largest tract system leading from the brain to the spinal cord, the corticospinal tract (CST). The developing CST grows down the spinal cord during the first postnatal days and innervates its targets after a waiting period by collateral sprouting. We find that NT-3 injected locally specifically enhances this sprouting, whereas BDNF has no effect. In adult rats, injection of NT-3 (but not BDNF) into the lesioned spinal cord increases the regenerative sprouting of the transected CST. The distance of growth of the sprouts is very restricted, but application of an antibody that neutralizes myelin-associated neurite growth inhibitory proteins results in long-distance regeneration of CST fibres.</abstract><cop>London</cop><pub>Nature Publishing</pub><pmid>8114912</pmid><doi>10.1038/367170a0</doi><tpages>4</tpages></addata></record> |
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| ispartof | Nature (London), 1994-01, Vol.367 (6459), p.170-173 |
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| subjects | Animals Animals, Newborn Biological and medical sciences Brain-Derived Neurotrophic Factor Development. Senescence. Regeneration. Transplantation Fundamental and applied biological sciences. Psychology Nerve Growth Factors - pharmacology Nerve Regeneration - drug effects Nerve Tissue Proteins - pharmacology Neurology Neurotrophin 3 Physical growth Pyramidal Tracts - drug effects Pyramidal Tracts - growth & development Rats Rats, Inbred Lew Spinal Cord Injuries - drug therapy Spinal Cord Injuries - physiopathology Spine Vertebrates: nervous system and sense organs |
| title | Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion |
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