Prediction of Available Surface Area of Powdered Particles of Flufenamic Acid in Tablets
A theoretical method was developed to describe the time course of the available surface area (S (t)) in the dissolution process of solid dosage forms. In general, dissolution of solid dosage forms includes disintegration and deaggregation (dispersion of disintegrated granules and powders), and since...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1985/04/25, Vol.33(4), pp.1641-1651 |
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| container_title | Chemical & pharmaceutical bulletin |
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| creator | KOUCHIWA, SHOZO NEMOTO, MASAMI ITAI, SHIGERU MURAYAMA, HIROSHI NAGAI, TSUNEJI |
| description | A theoretical method was developed to describe the time course of the available surface area (S (t)) in the dissolution process of solid dosage forms. In general, dissolution of solid dosage forms includes disintegration and deaggregation (dispersion of disintegrated granules and powders), and since the mechanism is very complex, S (t) in the dissolution medium cannot be determined by numerical calculation. However, the integrated value of S (t), which can be considered to be the available surface area generated during the dissolution time course, can be calculated from the dissolved amount and the dissolution parameters. In addition, the ratio of the available surface area generated by time t to the total available surface generated can be regarded as a cumulative probability distribution. By the regression of this ratio (F(t)) to the probability distribution, the time course of S (t) was able to be determined numerically. The application of this theory to the dissolution of flufenamic acid in tablets is described. |
| doi_str_mv | 10.1248/cpb.33.1641 |
| format | Article |
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In general, dissolution of solid dosage forms includes disintegration and deaggregation (dispersion of disintegrated granules and powders), and since the mechanism is very complex, S (t) in the dissolution medium cannot be determined by numerical calculation. However, the integrated value of S (t), which can be considered to be the available surface area generated during the dissolution time course, can be calculated from the dissolved amount and the dissolution parameters. In addition, the ratio of the available surface area generated by time t to the total available surface generated can be regarded as a cumulative probability distribution. By the regression of this ratio (F(t)) to the probability distribution, the time course of S (t) was able to be determined numerically. The application of this theory to the dissolution of flufenamic acid in tablets is described.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.33.1641</identifier><identifier>PMID: 4042240</identifier><identifier>CODEN: CPBTAL</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Biological and medical sciences ; flufenamic acid ; Flufenamic Acid - administration & dosage ; Flufenamic Acid - analysis ; General pharmacology ; Medical sciences ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Powders ; Surface Properties ; Tablets</subject><ispartof>Chemical and Pharmaceutical Bulletin, 1985/04/25, Vol.33(4), pp.1641-1651</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>1986 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 1985</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4841-653b637e63679c72bd91fad764f782131534b9f966fe51242ef9dda72323ff863</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8602312$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4042240$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KOUCHIWA, SHOZO</creatorcontrib><creatorcontrib>NEMOTO, MASAMI</creatorcontrib><creatorcontrib>ITAI, SHIGERU</creatorcontrib><creatorcontrib>MURAYAMA, HIROSHI</creatorcontrib><creatorcontrib>NAGAI, TSUNEJI</creatorcontrib><title>Prediction of Available Surface Area of Powdered Particles of Flufenamic Acid in Tablets</title><title>Chemical & pharmaceutical bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>A theoretical method was developed to describe the time course of the available surface area (S (t)) in the dissolution process of solid dosage forms. In general, dissolution of solid dosage forms includes disintegration and deaggregation (dispersion of disintegrated granules and powders), and since the mechanism is very complex, S (t) in the dissolution medium cannot be determined by numerical calculation. However, the integrated value of S (t), which can be considered to be the available surface area generated during the dissolution time course, can be calculated from the dissolved amount and the dissolution parameters. In addition, the ratio of the available surface area generated by time t to the total available surface generated can be regarded as a cumulative probability distribution. By the regression of this ratio (F(t)) to the probability distribution, the time course of S (t) was able to be determined numerically. The application of this theory to the dissolution of flufenamic acid in tablets is described.</description><subject>Biological and medical sciences</subject><subject>flufenamic acid</subject><subject>Flufenamic Acid - administration & dosage</subject><subject>Flufenamic Acid - analysis</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Powders</subject><subject>Surface Properties</subject><subject>Tablets</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkFFrFDEUhUOptGv1qc-FgYovMtskN5NkHpdqVSi4YAXfQiZzo1lmZ9ZkRvHfN8MOK_iSCznfPSc5hFwzumZc6Dt3aNYAayYFOyMrBkKVFedwTlaU0rrkIOGSvExpRymvqIILciGo4FzQFfm-jdgGN4ahLwZfbH7b0Nmmw-LrFL11WGwi2lnZDn9azGyxtXEMrsM03z50k8fe7oMrNi60ReiLp3l9TK_IC2-7hK-XeUW-PXx4uv9UPn75-Pl-81g6oQUrZQWNBIUSpKqd4k1bM29bJYVXmjNgFYim9rWUHqv8W46-blurOHDwXku4Im-Pvoc4_JowjWYfksOusz0OUzIquzNViwze_gfuhin2-W2GCUmp0FrTTL07Ui4OKUX05hDD3sa_hlEzt21y2wbAzG1n-mbxnJo9tid2qTfrbxbdJmc7H23vQjphWlIOjGfs_RHbpdH-wJO-ND1HsrrSc6w4HnP6P_mnjQZ7eAZt3Jx9</recordid><startdate>1985</startdate><enddate>1985</enddate><creator>KOUCHIWA, SHOZO</creator><creator>NEMOTO, MASAMI</creator><creator>ITAI, SHIGERU</creator><creator>MURAYAMA, HIROSHI</creator><creator>NAGAI, TSUNEJI</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1985</creationdate><title>Prediction of Available Surface Area of Powdered Particles of Flufenamic Acid in Tablets</title><author>KOUCHIWA, SHOZO ; NEMOTO, MASAMI ; ITAI, SHIGERU ; MURAYAMA, HIROSHI ; NAGAI, TSUNEJI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4841-653b637e63679c72bd91fad764f782131534b9f966fe51242ef9dda72323ff863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Biological and medical sciences</topic><topic>flufenamic acid</topic><topic>Flufenamic Acid - administration & dosage</topic><topic>Flufenamic Acid - analysis</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Powders</topic><topic>Surface Properties</topic><topic>Tablets</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KOUCHIWA, SHOZO</creatorcontrib><creatorcontrib>NEMOTO, MASAMI</creatorcontrib><creatorcontrib>ITAI, SHIGERU</creatorcontrib><creatorcontrib>MURAYAMA, HIROSHI</creatorcontrib><creatorcontrib>NAGAI, TSUNEJI</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KOUCHIWA, SHOZO</au><au>NEMOTO, MASAMI</au><au>ITAI, SHIGERU</au><au>MURAYAMA, HIROSHI</au><au>NAGAI, TSUNEJI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prediction of Available Surface Area of Powdered Particles of Flufenamic Acid in Tablets</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>1985</date><risdate>1985</risdate><volume>33</volume><issue>4</issue><spage>1641</spage><epage>1651</epage><pages>1641-1651</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><coden>CPBTAL</coden><abstract>A theoretical method was developed to describe the time course of the available surface area (S (t)) in the dissolution process of solid dosage forms. In general, dissolution of solid dosage forms includes disintegration and deaggregation (dispersion of disintegrated granules and powders), and since the mechanism is very complex, S (t) in the dissolution medium cannot be determined by numerical calculation. However, the integrated value of S (t), which can be considered to be the available surface area generated during the dissolution time course, can be calculated from the dissolved amount and the dissolution parameters. In addition, the ratio of the available surface area generated by time t to the total available surface generated can be regarded as a cumulative probability distribution. By the regression of this ratio (F(t)) to the probability distribution, the time course of S (t) was able to be determined numerically. The application of this theory to the dissolution of flufenamic acid in tablets is described.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>4042240</pmid><doi>10.1248/cpb.33.1641</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Biological and medical sciences flufenamic acid Flufenamic Acid - administration & dosage Flufenamic Acid - analysis General pharmacology Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Powders Surface Properties Tablets |
| title | Prediction of Available Surface Area of Powdered Particles of Flufenamic Acid in Tablets |
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