Vasopressin induced production of inositol trisphosphate and calcium efflux in a smooth muscle cell line
Phosphatidylinositol metabolism and 45Ca 2+ efflux were examined in a vascular smooth muscle cell line (A 7r 5). [Arg 8]Vasopressin stimulated the rapid formation (measurable at 1 sec) of inositol phosphates in a concentration-dependent manner. The time course for formation of inositol phosphates wa...
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| Veröffentlicht in: | Biochem. Biophys. Res. Commun.; (United States) 1985-08, Vol.131 (1), p.469-476 |
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| creator | Doyle, Valerie M. Rüegg, Urs T. |
| description | Phosphatidylinositol metabolism and
45Ca
2+ efflux were examined in a vascular smooth muscle cell line (A
7r
5). [Arg
8]Vasopressin stimulated the rapid formation (measurable at 1 sec) of inositol phosphates in a concentration-dependent manner. The time course for formation of inositol phosphates was similar to that for
45Ca
2+ efflux from preloaded cells. The efflux of
45Ca
2+ in response to [Arg
8]vasopressin could be inhibited by a vasopressin antagonist. This supports the hypothesis that inositol 1,4,5-trisphosphate plays a role in vasopressin stimulated calcium mobilisation from an intracellular source in cultured vascular smooth muscle cells. |
| doi_str_mv | 10.1016/0006-291X(85)91826-1 |
| format | Article |
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45Ca
2+ efflux were examined in a vascular smooth muscle cell line (A
7r
5). [Arg
8]Vasopressin stimulated the rapid formation (measurable at 1 sec) of inositol phosphates in a concentration-dependent manner. The time course for formation of inositol phosphates was similar to that for
45Ca
2+ efflux from preloaded cells. The efflux of
45Ca
2+ in response to [Arg
8]vasopressin could be inhibited by a vasopressin antagonist. This supports the hypothesis that inositol 1,4,5-trisphosphate plays a role in vasopressin stimulated calcium mobilisation from an intracellular source in cultured vascular smooth muscle cells.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/0006-291X(85)91826-1</identifier><identifier>PMID: 2994663</identifier><identifier>CODEN: BBRCA9</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>560171 - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987) ; ALKALINE EARTH ISOTOPES ; ANIMALS ; Applied sciences ; Arginine Vasopressin - analogs & derivatives ; Arginine Vasopressin - antagonists & inhibitors ; Arginine Vasopressin - pharmacology ; BETA DECAY RADIOISOTOPES ; BETA-MINUS DECAY RADIOISOTOPES ; BIOCHEMICAL REACTION KINETICS ; BIOLOGICAL EFFECTS ; calcium ; Calcium - metabolism ; CALCIUM 45 ; CALCIUM ISOTOPES ; Calcium Radioisotopes - metabolism ; CARBOHYDRATES ; CATIONS ; Cell Line ; CHARGED PARTICLES ; Chlorides - pharmacology ; DAYS LIVING RADIOISOTOPES ; EVEN-ODD NUCLEI ; Exact sciences and technology ; HORMONES ; INOSITOL ; Inositol 1,4,5-Trisphosphate ; Inositol Phosphates - biosynthesis ; INOSITOLS ; INTERMEDIATE MASS NUCLEI ; IONS ; ISOTOPES ; KINETICS ; Lithium - pharmacology ; Lithium Chloride ; MAMMALS ; MEMBRANE TRANSPORT ; METABOLISM ; MONOSACCHARIDES ; Muscle, Smooth, Vascular - drug effects ; Muscle, Smooth, Vascular - metabolism ; MUSCLES ; NUCLEI ; ORGANIC COMPOUNDS ; Other techniques and industries ; PEPTIDE HORMONES ; PITUITARY HORMONES ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RADIOISOTOPES ; RATS ; REACTION KINETICS ; RODENTS ; SACCHARIDES ; smooth muscle ; Sugar Phosphates - biosynthesis ; VASOPRESSIN ; VERTEBRATES</subject><ispartof>Biochem. Biophys. Res. Commun.; (United States), 1985-08, Vol.131 (1), p.469-476</ispartof><rights>1985</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-85e42355f7f53845afc2053779c222b2b419e9d963f4b9e6488e2a3114e3ffb83</citedby><cites>FETCH-LOGICAL-c444t-85e42355f7f53845afc2053779c222b2b419e9d963f4b9e6488e2a3114e3ffb83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-291X(85)91826-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7974108$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2994663$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/6378361$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Doyle, Valerie M.</creatorcontrib><creatorcontrib>Rüegg, Urs T.</creatorcontrib><creatorcontrib>Sandoz Ltd., Basel, Switzerland</creatorcontrib><title>Vasopressin induced production of inositol trisphosphate and calcium efflux in a smooth muscle cell line</title><title>Biochem. Biophys. Res. Commun.; (United States)</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Phosphatidylinositol metabolism and
45Ca
2+ efflux were examined in a vascular smooth muscle cell line (A
7r
5). [Arg
8]Vasopressin stimulated the rapid formation (measurable at 1 sec) of inositol phosphates in a concentration-dependent manner. The time course for formation of inositol phosphates was similar to that for
45Ca
2+ efflux from preloaded cells. The efflux of
45Ca
2+ in response to [Arg
8]vasopressin could be inhibited by a vasopressin antagonist. This supports the hypothesis that inositol 1,4,5-trisphosphate plays a role in vasopressin stimulated calcium mobilisation from an intracellular source in cultured vascular smooth muscle cells.</description><subject>560171 - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987)</subject><subject>ALKALINE EARTH ISOTOPES</subject><subject>ANIMALS</subject><subject>Applied sciences</subject><subject>Arginine Vasopressin - analogs & derivatives</subject><subject>Arginine Vasopressin - antagonists & inhibitors</subject><subject>Arginine Vasopressin - pharmacology</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>BETA-MINUS DECAY RADIOISOTOPES</subject><subject>BIOCHEMICAL REACTION KINETICS</subject><subject>BIOLOGICAL EFFECTS</subject><subject>calcium</subject><subject>Calcium - metabolism</subject><subject>CALCIUM 45</subject><subject>CALCIUM ISOTOPES</subject><subject>Calcium Radioisotopes - metabolism</subject><subject>CARBOHYDRATES</subject><subject>CATIONS</subject><subject>Cell Line</subject><subject>CHARGED PARTICLES</subject><subject>Chlorides - pharmacology</subject><subject>DAYS LIVING RADIOISOTOPES</subject><subject>EVEN-ODD NUCLEI</subject><subject>Exact sciences and technology</subject><subject>HORMONES</subject><subject>INOSITOL</subject><subject>Inositol 1,4,5-Trisphosphate</subject><subject>Inositol Phosphates - biosynthesis</subject><subject>INOSITOLS</subject><subject>INTERMEDIATE MASS NUCLEI</subject><subject>IONS</subject><subject>ISOTOPES</subject><subject>KINETICS</subject><subject>Lithium - pharmacology</subject><subject>Lithium Chloride</subject><subject>MAMMALS</subject><subject>MEMBRANE TRANSPORT</subject><subject>METABOLISM</subject><subject>MONOSACCHARIDES</subject><subject>Muscle, Smooth, Vascular - drug effects</subject><subject>Muscle, Smooth, Vascular - metabolism</subject><subject>MUSCLES</subject><subject>NUCLEI</subject><subject>ORGANIC COMPOUNDS</subject><subject>Other techniques and industries</subject><subject>PEPTIDE HORMONES</subject><subject>PITUITARY HORMONES</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RADIOISOTOPES</subject><subject>RATS</subject><subject>REACTION KINETICS</subject><subject>RODENTS</subject><subject>SACCHARIDES</subject><subject>smooth muscle</subject><subject>Sugar Phosphates - biosynthesis</subject><subject>VASOPRESSIN</subject><subject>VERTEBRATES</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuLFDEUhYMoY8_oP1AIIqKL0rwqqWwGZBgfMOBGxV1IpW7oSFXSJinRf2_Kbnqpi5CQ-93DPfcg9ISS15RQ-YYQIjum6beXQ_9K04HJjt5DO0o06Rgl4j7anZGH6LKU74RQKqS-QBdMayEl36H9V1vSIUMpIeIQp9XBhA85tUcNKeLk228qoaYZ1xzKYZ_asRWwjRN2dnZhXTB4P6-_GoktLktKdY-XtbgZsIN5xnOI8Ag98HYu8Ph0X6Ev724_33zo7j69_3jz9q5zQojaDT0IxvveK9_zQfTWO0Z6rpR2jLGRjYJq0JOW3ItRgxTDAMzy5gu49-PAr9Czo24qNZjiQgW3dylGcNVIrgYuaYNeHKHm9McKpZollG1UGyGtxagGEkXlf0EqRK-l2hTFEXQ5lZLBm0MOi82_DSVmi8tsWZgtCzP05m9cZmt7etJfxwWmc9Mpn1Z_fqrb0pbts40ulDOmtBKUbKavjxi0zf4MkDfjEFuWIW--pxT-PccfkvCxMQ</recordid><startdate>19850830</startdate><enddate>19850830</enddate><creator>Doyle, Valerie M.</creator><creator>Rüegg, Urs T.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>19850830</creationdate><title>Vasopressin induced production of inositol trisphosphate and calcium efflux in a smooth muscle cell line</title><author>Doyle, Valerie M. ; Rüegg, Urs T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-85e42355f7f53845afc2053779c222b2b419e9d963f4b9e6488e2a3114e3ffb83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>560171 - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987)</topic><topic>ALKALINE EARTH ISOTOPES</topic><topic>ANIMALS</topic><topic>Applied sciences</topic><topic>Arginine Vasopressin - analogs & derivatives</topic><topic>Arginine Vasopressin - antagonists & inhibitors</topic><topic>Arginine Vasopressin - pharmacology</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>BETA-MINUS DECAY RADIOISOTOPES</topic><topic>BIOCHEMICAL REACTION KINETICS</topic><topic>BIOLOGICAL EFFECTS</topic><topic>calcium</topic><topic>Calcium - metabolism</topic><topic>CALCIUM 45</topic><topic>CALCIUM ISOTOPES</topic><topic>Calcium Radioisotopes - metabolism</topic><topic>CARBOHYDRATES</topic><topic>CATIONS</topic><topic>Cell Line</topic><topic>CHARGED PARTICLES</topic><topic>Chlorides - pharmacology</topic><topic>DAYS LIVING RADIOISOTOPES</topic><topic>EVEN-ODD NUCLEI</topic><topic>Exact sciences and technology</topic><topic>HORMONES</topic><topic>INOSITOL</topic><topic>Inositol 1,4,5-Trisphosphate</topic><topic>Inositol Phosphates - biosynthesis</topic><topic>INOSITOLS</topic><topic>INTERMEDIATE MASS NUCLEI</topic><topic>IONS</topic><topic>ISOTOPES</topic><topic>KINETICS</topic><topic>Lithium - pharmacology</topic><topic>Lithium Chloride</topic><topic>MAMMALS</topic><topic>MEMBRANE TRANSPORT</topic><topic>METABOLISM</topic><topic>MONOSACCHARIDES</topic><topic>Muscle, Smooth, Vascular - drug effects</topic><topic>Muscle, Smooth, Vascular - metabolism</topic><topic>MUSCLES</topic><topic>NUCLEI</topic><topic>ORGANIC COMPOUNDS</topic><topic>Other techniques and industries</topic><topic>PEPTIDE HORMONES</topic><topic>PITUITARY HORMONES</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RADIOISOTOPES</topic><topic>RATS</topic><topic>REACTION KINETICS</topic><topic>RODENTS</topic><topic>SACCHARIDES</topic><topic>smooth muscle</topic><topic>Sugar Phosphates - biosynthesis</topic><topic>VASOPRESSIN</topic><topic>VERTEBRATES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Doyle, Valerie M.</creatorcontrib><creatorcontrib>Rüegg, Urs T.</creatorcontrib><creatorcontrib>Sandoz Ltd., Basel, Switzerland</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Biochem. Biophys. Res. Commun.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Doyle, Valerie M.</au><au>Rüegg, Urs T.</au><aucorp>Sandoz Ltd., Basel, Switzerland</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vasopressin induced production of inositol trisphosphate and calcium efflux in a smooth muscle cell line</atitle><jtitle>Biochem. Biophys. Res. Commun.; (United States)</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1985-08-30</date><risdate>1985</risdate><volume>131</volume><issue>1</issue><spage>469</spage><epage>476</epage><pages>469-476</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><coden>BBRCA9</coden><abstract>Phosphatidylinositol metabolism and
45Ca
2+ efflux were examined in a vascular smooth muscle cell line (A
7r
5). [Arg
8]Vasopressin stimulated the rapid formation (measurable at 1 sec) of inositol phosphates in a concentration-dependent manner. The time course for formation of inositol phosphates was similar to that for
45Ca
2+ efflux from preloaded cells. The efflux of
45Ca
2+ in response to [Arg
8]vasopressin could be inhibited by a vasopressin antagonist. This supports the hypothesis that inositol 1,4,5-trisphosphate plays a role in vasopressin stimulated calcium mobilisation from an intracellular source in cultured vascular smooth muscle cells.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>2994663</pmid><doi>10.1016/0006-291X(85)91826-1</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-291X |
| ispartof | Biochem. Biophys. Res. Commun.; (United States), 1985-08, Vol.131 (1), p.469-476 |
| issn | 0006-291X 1090-2104 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76370716 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | 560171 - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987) ALKALINE EARTH ISOTOPES ANIMALS Applied sciences Arginine Vasopressin - analogs & derivatives Arginine Vasopressin - antagonists & inhibitors Arginine Vasopressin - pharmacology BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES BIOCHEMICAL REACTION KINETICS BIOLOGICAL EFFECTS calcium Calcium - metabolism CALCIUM 45 CALCIUM ISOTOPES Calcium Radioisotopes - metabolism CARBOHYDRATES CATIONS Cell Line CHARGED PARTICLES Chlorides - pharmacology DAYS LIVING RADIOISOTOPES EVEN-ODD NUCLEI Exact sciences and technology HORMONES INOSITOL Inositol 1,4,5-Trisphosphate Inositol Phosphates - biosynthesis INOSITOLS INTERMEDIATE MASS NUCLEI IONS ISOTOPES KINETICS Lithium - pharmacology Lithium Chloride MAMMALS MEMBRANE TRANSPORT METABOLISM MONOSACCHARIDES Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism MUSCLES NUCLEI ORGANIC COMPOUNDS Other techniques and industries PEPTIDE HORMONES PITUITARY HORMONES RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOISOTOPES RATS REACTION KINETICS RODENTS SACCHARIDES smooth muscle Sugar Phosphates - biosynthesis VASOPRESSIN VERTEBRATES |
| title | Vasopressin induced production of inositol trisphosphate and calcium efflux in a smooth muscle cell line |
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