Persistence of Type-Specific Human Papillomavirus Infection among Cytologically Normal Women
Determinants of genital human papillomavirus (HPV) persistence in 393 women initially cytologically normal were investigated by testing them for HPV DNA twice over a median interval of 14.9 months. At each visit, interview information was obtained and a cervicovaginal lavage sample was collected for...
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| Veröffentlicht in: | The Journal of infectious diseases 1994-02, Vol.169 (2), p.235-240 |
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| creator | Hildesheim, Allan Schiffman, Mark H. Gravitt, Patti E. Glass, Andrew G. Greer, Catherine E. Zhang, Tracy Scott, David R. Rush, Brenda B. Lawler, Patricia Sherman, Mark E. Kurman, Robert J. Manos, M. Michele |
| description | Determinants of genital human papillomavirus (HPV) persistence in 393 women initially cytologically normal were investigated by testing them for HPV DNA twice over a median interval of 14.9 months. At each visit, interview information was obtained and a cervicovaginal lavage sample was collected for polymerase chain reaction-based HPV testing. Twenty-six percent of the women were HPV-positive at the first sampling. Data on HPV type was available for 86 HPV-positive women (84%); 35 of these women (41%) had persistent type-specific HPV detection. Persistence decreased with time between samplings. Women aged 2A7E;30 years had a higher percentage of persistence (65%) than those 2A7D;24 years (32%, P = .02). The percentage of persistence was higher among women infected with HPV types known to be cancer-associated (45%) than among those infected with other types (24%, P = .11). These findings were independent of each other and of timing between samplings. Although based on a prevalent cohort, these results are concordant with previous suggestions that HPV infection is usually transient and that cervical cancer may arise from within the subset of women with persistent HPV infection. |
| doi_str_mv | 10.1093/infdis/169.2.235 |
| format | Article |
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Michele</creator><creatorcontrib>Hildesheim, Allan ; Schiffman, Mark H. ; Gravitt, Patti E. ; Glass, Andrew G. ; Greer, Catherine E. ; Zhang, Tracy ; Scott, David R. ; Rush, Brenda B. ; Lawler, Patricia ; Sherman, Mark E. ; Kurman, Robert J. ; Manos, M. Michele</creatorcontrib><description>Determinants of genital human papillomavirus (HPV) persistence in 393 women initially cytologically normal were investigated by testing them for HPV DNA twice over a median interval of 14.9 months. At each visit, interview information was obtained and a cervicovaginal lavage sample was collected for polymerase chain reaction-based HPV testing. Twenty-six percent of the women were HPV-positive at the first sampling. Data on HPV type was available for 86 HPV-positive women (84%); 35 of these women (41%) had persistent type-specific HPV detection. Persistence decreased with time between samplings. Women aged 2A7E;30 years had a higher percentage of persistence (65%) than those 2A7D;24 years (32%, P = .02). The percentage of persistence was higher among women infected with HPV types known to be cancer-associated (45%) than among those infected with other types (24%, P = .11). These findings were independent of each other and of timing between samplings. Although based on a prevalent cohort, these results are concordant with previous suggestions that HPV infection is usually transient and that cervical cancer may arise from within the subset of women with persistent HPV infection.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/169.2.235</identifier><identifier>PMID: 8106758</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adolescent ; Adult ; Age Factors ; Aged ; Base Sequence ; Biological and medical sciences ; Cervical cancer ; Cervix Uteri - virology ; DNA Primers - chemistry ; DNA Probes, HPV ; Epidemiology ; Female ; Genitalia ; Human viral diseases ; Humans ; Infections ; Infectious diseases ; Major Articles ; Medical sciences ; Middle Aged ; Molecular Sequence Data ; Neoplasia ; Oligonucleotide Probes - chemistry ; Papillomaviridae ; Papillomavirus infections ; Papillomavirus Infections - pathology ; Papillomavirus Infections - virology ; Polymerase chain reaction ; Therapeutic irrigation ; Time Factors ; Tobacco smoking ; Tumor Virus Infections - pathology ; Tumor Virus Infections - virology ; Viral diseases ; Viral diseases of the genital and urinary system ; Viruses</subject><ispartof>The Journal of infectious diseases, 1994-02, Vol.169 (2), p.235-240</ispartof><rights>Copyright 1994 The University of Chicago</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-b6fd353f4111bce38dd2621cbc1c3170060cbe38a04c2ed7434952bd6e4daffa3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30113898$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30113898$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4071674$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8106758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hildesheim, Allan</creatorcontrib><creatorcontrib>Schiffman, Mark H.</creatorcontrib><creatorcontrib>Gravitt, Patti E.</creatorcontrib><creatorcontrib>Glass, Andrew G.</creatorcontrib><creatorcontrib>Greer, Catherine E.</creatorcontrib><creatorcontrib>Zhang, Tracy</creatorcontrib><creatorcontrib>Scott, David R.</creatorcontrib><creatorcontrib>Rush, Brenda B.</creatorcontrib><creatorcontrib>Lawler, Patricia</creatorcontrib><creatorcontrib>Sherman, Mark E.</creatorcontrib><creatorcontrib>Kurman, Robert J.</creatorcontrib><creatorcontrib>Manos, M. Michele</creatorcontrib><title>Persistence of Type-Specific Human Papillomavirus Infection among Cytologically Normal Women</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Determinants of genital human papillomavirus (HPV) persistence in 393 women initially cytologically normal were investigated by testing them for HPV DNA twice over a median interval of 14.9 months. At each visit, interview information was obtained and a cervicovaginal lavage sample was collected for polymerase chain reaction-based HPV testing. Twenty-six percent of the women were HPV-positive at the first sampling. Data on HPV type was available for 86 HPV-positive women (84%); 35 of these women (41%) had persistent type-specific HPV detection. Persistence decreased with time between samplings. Women aged 2A7E;30 years had a higher percentage of persistence (65%) than those 2A7D;24 years (32%, P = .02). The percentage of persistence was higher among women infected with HPV types known to be cancer-associated (45%) than among those infected with other types (24%, P = .11). These findings were independent of each other and of timing between samplings. Although based on a prevalent cohort, these results are concordant with previous suggestions that HPV infection is usually transient and that cervical cancer may arise from within the subset of women with persistent HPV infection.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cervical cancer</subject><subject>Cervix Uteri - virology</subject><subject>DNA Primers - chemistry</subject><subject>DNA Probes, HPV</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Genitalia</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Major Articles</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular Sequence Data</subject><subject>Neoplasia</subject><subject>Oligonucleotide Probes - chemistry</subject><subject>Papillomaviridae</subject><subject>Papillomavirus infections</subject><subject>Papillomavirus Infections - pathology</subject><subject>Papillomavirus Infections - virology</subject><subject>Polymerase chain reaction</subject><subject>Therapeutic irrigation</subject><subject>Time Factors</subject><subject>Tobacco smoking</subject><subject>Tumor Virus Infections - pathology</subject><subject>Tumor Virus Infections - virology</subject><subject>Viral diseases</subject><subject>Viral diseases of the genital and urinary system</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9v0zAYhi0EGt3gzgUpB8QtnT_bsZMj6mAdqmDSyg8hJMtx7MnDsYOdTPS_J1VLr5ws-XnfV_JjhF4BXgJu6KULtnP5EnizJEtCqydoARUVJedAn6IFxoSUUDfNc3Se8wPGmFEuztBZDZiLql6gn7cmZZdHE7Qpoi22u8GUd4PRzjpdrKdeheJWDc772KtHl6Zc3ARr9OhiKFQfw32x2o3Rx3unlfe74lNMvfLFt9ib8AI9s8pn8_J4XqAvH95vV-ty8_n6ZvVuU2oGbCxbbjtaUcsAoNWG1l1HOAHdatAUBMYc63a-VphpYjrBKGsq0nbcsE5Zq-gFenvYHVL8PZk8yt5lbbxXwcQpS8Fp1VRA_hsEXjNRk2oO4kNQp5hzMlYOyfUq7SRguTcvD-bnRiOJnM3PldfH7antTXcqHFXP_M2RqzyrskkFPQ_8izEsgM9PO8085DGmE6YYgNbNfqY88P2n_TlxlX5JLqio5Pr7D7m5Fncfv26vJKd_Aa68pzQ</recordid><startdate>19940201</startdate><enddate>19940201</enddate><creator>Hildesheim, Allan</creator><creator>Schiffman, Mark H.</creator><creator>Gravitt, Patti E.</creator><creator>Glass, Andrew G.</creator><creator>Greer, Catherine E.</creator><creator>Zhang, Tracy</creator><creator>Scott, David R.</creator><creator>Rush, Brenda B.</creator><creator>Lawler, Patricia</creator><creator>Sherman, Mark E.</creator><creator>Kurman, Robert J.</creator><creator>Manos, M. 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Michele</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Persistence of Type-Specific Human Papillomavirus Infection among Cytologically Normal Women</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1994-02-01</date><risdate>1994</risdate><volume>169</volume><issue>2</issue><spage>235</spage><epage>240</epage><pages>235-240</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Determinants of genital human papillomavirus (HPV) persistence in 393 women initially cytologically normal were investigated by testing them for HPV DNA twice over a median interval of 14.9 months. At each visit, interview information was obtained and a cervicovaginal lavage sample was collected for polymerase chain reaction-based HPV testing. Twenty-six percent of the women were HPV-positive at the first sampling. Data on HPV type was available for 86 HPV-positive women (84%); 35 of these women (41%) had persistent type-specific HPV detection. Persistence decreased with time between samplings. Women aged 2A7E;30 years had a higher percentage of persistence (65%) than those 2A7D;24 years (32%, P = .02). The percentage of persistence was higher among women infected with HPV types known to be cancer-associated (45%) than among those infected with other types (24%, P = .11). These findings were independent of each other and of timing between samplings. Although based on a prevalent cohort, these results are concordant with previous suggestions that HPV infection is usually transient and that cervical cancer may arise from within the subset of women with persistent HPV infection.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>8106758</pmid><doi>10.1093/infdis/169.2.235</doi><tpages>6</tpages></addata></record> |
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| ispartof | The Journal of infectious diseases, 1994-02, Vol.169 (2), p.235-240 |
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| source | Jstor Complete Legacy; MEDLINE |
| subjects | Adolescent Adult Age Factors Aged Base Sequence Biological and medical sciences Cervical cancer Cervix Uteri - virology DNA Primers - chemistry DNA Probes, HPV Epidemiology Female Genitalia Human viral diseases Humans Infections Infectious diseases Major Articles Medical sciences Middle Aged Molecular Sequence Data Neoplasia Oligonucleotide Probes - chemistry Papillomaviridae Papillomavirus infections Papillomavirus Infections - pathology Papillomavirus Infections - virology Polymerase chain reaction Therapeutic irrigation Time Factors Tobacco smoking Tumor Virus Infections - pathology Tumor Virus Infections - virology Viral diseases Viral diseases of the genital and urinary system Viruses |
| title | Persistence of Type-Specific Human Papillomavirus Infection among Cytologically Normal Women |
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