Mitochondrial respiratory chain inhibitors induce apoptosis
In this paper the specific mitochondrial respiratory chain inhibitors rotenone and antimycin A and the highly specific mitochondrial ATP-synthase inhibitor oligomycin are shown to induce an apoptotic suicide response in cultured human lymphoblastoid and other mammalian cells within 12–18 h. The mito...
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| Veröffentlicht in: | FEBS letters 1994-02, Vol.339 (1-2), p.40-44 |
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| container_title | FEBS letters |
| container_volume | 339 |
| creator | Wolvetang, Ernst J. Johnson, Karina L. Krauer, Kenia Ralph, Steve J. Linnane, Anthony W. |
| description | In this paper the specific mitochondrial respiratory chain inhibitors rotenone and antimycin A and the highly specific mitochondrial ATP-synthase inhibitor oligomycin are shown to induce an apoptotic suicide response in cultured human lymphoblastoid and other mammalian cells within 12–18 h. The mitochondrial inhibitors do not induce apoptosis in cells depleted of mitochondrial DNA and thus lacking an intact mitochondrial respiratory chain. Apoptosis induced by respiratory chain inhibitors is not inhibited by the presence of Bcl-2. We discuss the possible role of mitochondrial induced apoptosis in the ageing process and age-associated diseases. |
| doi_str_mv | 10.1016/0014-5793(94)80380-3 |
| format | Article |
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The mitochondrial inhibitors do not induce apoptosis in cells depleted of mitochondrial DNA and thus lacking an intact mitochondrial respiratory chain. Apoptosis induced by respiratory chain inhibitors is not inhibited by the presence of Bcl-2. We discuss the possible role of mitochondrial induced apoptosis in the ageing process and age-associated diseases.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/0014-5793(94)80380-3</identifier><identifier>PMID: 8313978</identifier><identifier>CODEN: FEBLAL</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Ageing, cell death ; Animals ; Antimycin A - pharmacology ; Apoptosis - drug effects ; Biological and medical sciences ; Cell Nucleus - drug effects ; Cell physiology ; Culture Media ; DNA - drug effects ; Energy Metabolism - drug effects ; Fundamental and applied biological sciences. 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The mitochondrial inhibitors do not induce apoptosis in cells depleted of mitochondrial DNA and thus lacking an intact mitochondrial respiratory chain. Apoptosis induced by respiratory chain inhibitors is not inhibited by the presence of Bcl-2. We discuss the possible role of mitochondrial induced apoptosis in the ageing process and age-associated diseases.</description><subject>Ageing, cell death</subject><subject>Animals</subject><subject>Antimycin A - pharmacology</subject><subject>Apoptosis - drug effects</subject><subject>Biological and medical sciences</subject><subject>Cell Nucleus - drug effects</subject><subject>Cell physiology</subject><subject>Culture Media</subject><subject>DNA - drug effects</subject><subject>Energy Metabolism - drug effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human Lymphoblastoid cell</subject><subject>Humans</subject><subject>Leukemia</subject><subject>Melanoma</subject><subject>Melanoma cell</subject><subject>Mice</subject><subject>Molecular and cellular biology</subject><subject>Oligomycins - pharmacology</subject><subject>Proto-oncogene product Bcl-2</subject><subject>Proto-Oncogene Proteins - metabolism</subject><subject>Proto-Oncogene Proteins c-bcl-2</subject><subject>Rotenone - pharmacology</subject><subject>Tumor Cells, Cultured</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE9rGzEQxUVpSJyk36ABH0poDttIO7uShkIhDXETSOmlPQtZf7DCerWR1i3-9tHGxse2J0nzfvNm9Ah5z-gnRhm_ppQ1VSsQPmJzJSlIWsEbMmNSQAUNl2_J7ICckNOcn2h5S4bH5FgCAxRyRj5_D2M0q9jbFHQ3Ty4PIekxpu3crHTo56FfhWVhUi5XuzFuroc4jDGHfE6OvO6ye7c_z8ivxd3P2_vq8ce3h9ubx8q0WEPlgda0XoIQDbWotaydxxapQ1EErZFLjcYaq7lfomS-9iiEb8GytgZO4Yxc7nyHFJ83Lo9qHbJxXad7FzdZCQ4tp2XUv0DGsWFciAI2O9CkmHNyXg0prHXaKkbVFK6aklNTcgob9RqugtJ2sfffLNfOHpr2aRb9w17X2ejOJ92bkA8YoGw5TNMXO-xP6Nz2v0arxd3XehKmOjav1WmfLzsjV9L_HVxS2QTXG2dDcmZUNoa_f-gFrlun_w</recordid><startdate>19940214</startdate><enddate>19940214</enddate><creator>Wolvetang, Ernst J.</creator><creator>Johnson, Karina L.</creator><creator>Krauer, Kenia</creator><creator>Ralph, Steve J.</creator><creator>Linnane, Anthony W.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>19940214</creationdate><title>Mitochondrial respiratory chain inhibitors induce apoptosis</title><author>Wolvetang, Ernst J. ; Johnson, Karina L. ; Krauer, Kenia ; Ralph, Steve J. ; Linnane, Anthony W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5923-f30202b37740d9aa82ef9590e97020aa968a9cdcda6fb981f2f977f53d1523603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Ageing, cell death</topic><topic>Animals</topic><topic>Antimycin A - pharmacology</topic><topic>Apoptosis - drug effects</topic><topic>Biological and medical sciences</topic><topic>Cell Nucleus - drug effects</topic><topic>Cell physiology</topic><topic>Culture Media</topic><topic>DNA - drug effects</topic><topic>Energy Metabolism - drug effects</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human Lymphoblastoid cell</topic><topic>Humans</topic><topic>Leukemia</topic><topic>Melanoma</topic><topic>Melanoma cell</topic><topic>Mice</topic><topic>Molecular and cellular biology</topic><topic>Oligomycins - pharmacology</topic><topic>Proto-oncogene product Bcl-2</topic><topic>Proto-Oncogene Proteins - metabolism</topic><topic>Proto-Oncogene Proteins c-bcl-2</topic><topic>Rotenone - pharmacology</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wolvetang, Ernst J.</creatorcontrib><creatorcontrib>Johnson, Karina L.</creatorcontrib><creatorcontrib>Krauer, Kenia</creatorcontrib><creatorcontrib>Ralph, Steve J.</creatorcontrib><creatorcontrib>Linnane, Anthony W.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wolvetang, Ernst J.</au><au>Johnson, Karina L.</au><au>Krauer, Kenia</au><au>Ralph, Steve J.</au><au>Linnane, Anthony W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mitochondrial respiratory chain inhibitors induce apoptosis</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1994-02-14</date><risdate>1994</risdate><volume>339</volume><issue>1-2</issue><spage>40</spage><epage>44</epage><pages>40-44</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><coden>FEBLAL</coden><abstract>In this paper the specific mitochondrial respiratory chain inhibitors rotenone and antimycin A and the highly specific mitochondrial ATP-synthase inhibitor oligomycin are shown to induce an apoptotic suicide response in cultured human lymphoblastoid and other mammalian cells within 12–18 h. 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| ispartof | FEBS letters, 1994-02, Vol.339 (1-2), p.40-44 |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Ageing, cell death Animals Antimycin A - pharmacology Apoptosis - drug effects Biological and medical sciences Cell Nucleus - drug effects Cell physiology Culture Media DNA - drug effects Energy Metabolism - drug effects Fundamental and applied biological sciences. Psychology Human Lymphoblastoid cell Humans Leukemia Melanoma Melanoma cell Mice Molecular and cellular biology Oligomycins - pharmacology Proto-oncogene product Bcl-2 Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 Rotenone - pharmacology Tumor Cells, Cultured |
| title | Mitochondrial respiratory chain inhibitors induce apoptosis |
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