p135tyk2, an interferon-alpha-activated tyrosine kinase, is physically associated with an interferon-alpha receptor

Recent genetic studies have linked the tyk2 gene, which encodes a novel type of non-receptor tyrosine kinase, to the interferon-alpha intracellular signaling pathway. In this report, biochemical evidence is presented which supports this proposed function for the tyk2 tyrosine kinase and further defi...

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