Src family tyrosine kinase p53/56lyn, a serine kinase and Fc epsilon RI associate with alpha-galactosyl derivatives of ganglioside GD1b in rat basophilic leukemia RBL-2H3 cells

The monoclonal antibody (mAb) AA4 recognizes two alpha-galactosyl derivatives of the GD1b ganglioside on rat mast cells and on the rat basophilic leukemia RBL-2H3 cultured cell line. Here we demonstrate that mAb AA4 coprecipitated both protein tyrosine and serine kinases. In contrast, a monoclonal a...

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Veröffentlicht in:	The Journal of biological chemistry 1994-02, Vol.269 (7), p.5249-5254
Hauptverfasser:	MINOGUCHI, K, SWAIM, W. D, BERENSTEIN, E. H, SIRAGANIAN, R. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal Autoradiography Biological and medical sciences Cell Line Cell physiology Electrophoresis, Polyacrylamide Gel Fundamental and applied biological sciences. Psychology Galactosides - analysis Galactosides - metabolism Gangliosides - isolation & purification Gangliosides - metabolism Immunoblotting Leukemia, Basophilic, Acute Mast Cells - enzymology Molecular and cellular biology Molecular Weight Phosphorus Radioisotopes Protein-Serine-Threonine Kinases - isolation & purification Protein-Serine-Threonine Kinases - metabolism Protein-Tyrosine Kinases - isolation & purification Protein-Tyrosine Kinases - metabolism Rats Receptors, IgE - isolation & purification Receptors, IgE - metabolism Signal transduction src-Family Kinases Tumor Cells, Cultured
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