Benign-to-malignant B16 melanoma progression induced in two stages in vitro by exposure to hypoxia

Benign tumors apparently become malignant by generating a succession of variants with ever-greater growth potential and autonomy. Such stepwise progression has not been achieved in vitro under conditions likely to occur in developing tumors. Tumors initiated by clone G3.5 of the mouse B16 melanoma r...

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