Substance P increases neutrophil adhesion to bronchial epithelial cells

Polymorphonuclear neutrophils (PMNs) accumulate within the airways during acute and chronic bronchitis and can adhere to bronchial epithelium. Substance P (SP), a neuropeptide released from the primary afferent nerve endings, has been shown to have a proinflammatory effect on PMNs. To test the hypot...

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Veröffentlicht in:	The Journal of immunology (1950) 1994-02, Vol.152 (3), p.1339-1346
Hauptverfasser:	DeRose, V, Robbins, RA, Snider, RM, Spurzem, JR, Thiele, GM, Rennard, SI, Rubinstein, I
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biphenyl Compounds - pharmacology Bronchi - cytology Bronchi - immunology Cattle Cell Adhesion - drug effects Cell Adhesion Molecules - metabolism Epithelium - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology In Vitro Techniques Intercellular Adhesion Molecule-1 Lymphocyte Function-Associated Antigen-1 - metabolism Macrophage-1 Antigen - metabolism Myeloid cells: ontogeny, maturation, markers, receptors Neurokinin-1 Receptor Antagonists Neutrophils - cytology Peptide Fragments - pharmacology Polynuclears Rosette Formation Substance P - pharmacology Time Factors
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