Bile acids and lipid metabolism: II. Essential role of bile acids in bile phospholipid excretion
The isolated rat liver perfusion system has been used to study the release of bile phospholipid P 32 following the injection of inorganic P 32 into the perfusate. It was demonsrtated that in the absence of added bile salt very little PLP 32 was excreted into bile, but when bile salt was added to the...
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| Veröffentlicht in: | Archives of biochemistry and biophysics 1969-03, Vol.130 (1), p.253-256 |
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| container_title | Archives of biochemistry and biophysics |
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| creator | Entenman, Cecil Holloway, Roy J. Albright, M.L. Leong, George F. |
| description | The isolated rat liver perfusion system has been used to study the release of bile phospholipid P
32 following the injection of inorganic P
32 into the perfusate. It was demonsrtated that in the absence of added bile salt very little PLP
32 was excreted into bile, but when bile salt was added to the perfusate the PLP
32 excretion increased markedly. At the start of bile salt infusion, the specific activity of the bile phospholipids was lower than that of the liver, but at later times the specific activity of bile phospholipids was greater than liver PL specific activity. It is suggested that bile acids play an essential role in the transport of phospholipid from liver to bile. |
| doi_str_mv | 10.1016/0003-9861(69)90031-9 |
| format | Article |
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32 following the injection of inorganic P
32 into the perfusate. It was demonsrtated that in the absence of added bile salt very little PLP
32 was excreted into bile, but when bile salt was added to the perfusate the PLP
32 excretion increased markedly. At the start of bile salt infusion, the specific activity of the bile phospholipids was lower than that of the liver, but at later times the specific activity of bile phospholipids was greater than liver PL specific activity. It is suggested that bile acids play an essential role in the transport of phospholipid from liver to bile.</description><identifier>ISSN: 0003-9861</identifier><identifier>EISSN: 1096-0384</identifier><identifier>DOI: 10.1016/0003-9861(69)90031-9</identifier><identifier>PMID: 5778640</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Bile - metabolism ; Bile Acids and Salts - physiology ; In Vitro Techniques ; Liver - metabolism ; Male ; Perfusion ; Phospholipids - blood ; Phospholipids - metabolism ; Phosphorus Isotopes ; Rats ; Time Factors</subject><ispartof>Archives of biochemistry and biophysics, 1969-03, Vol.130 (1), p.253-256</ispartof><rights>1969</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0003986169900319$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5778640$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Entenman, Cecil</creatorcontrib><creatorcontrib>Holloway, Roy J.</creatorcontrib><creatorcontrib>Albright, M.L.</creatorcontrib><creatorcontrib>Leong, George F.</creatorcontrib><title>Bile acids and lipid metabolism: II. Essential role of bile acids in bile phospholipid excretion</title><title>Archives of biochemistry and biophysics</title><addtitle>Arch Biochem Biophys</addtitle><description>The isolated rat liver perfusion system has been used to study the release of bile phospholipid P
32 following the injection of inorganic P
32 into the perfusate. It was demonsrtated that in the absence of added bile salt very little PLP
32 was excreted into bile, but when bile salt was added to the perfusate the PLP
32 excretion increased markedly. At the start of bile salt infusion, the specific activity of the bile phospholipids was lower than that of the liver, but at later times the specific activity of bile phospholipids was greater than liver PL specific activity. It is suggested that bile acids play an essential role in the transport of phospholipid from liver to bile.</description><subject>Animals</subject><subject>Bile - metabolism</subject><subject>Bile Acids and Salts - physiology</subject><subject>In Vitro Techniques</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Perfusion</subject><subject>Phospholipids - blood</subject><subject>Phospholipids - metabolism</subject><subject>Phosphorus Isotopes</subject><subject>Rats</subject><subject>Time Factors</subject><issn>0003-9861</issn><issn>1096-0384</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1969</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFUU1LxDAUDKKs6-o_UMhJ9NA1aZq08SDosurCghc9x3y8YqRtatMV_fd27aKHx2OYecNjBqFTSuaUUHFFCGGJLAS9EPJSDoAmcg9NKZEiIazI9tH0T3KIjmJ8J4TSTKQTNOF5XoiMTNHrna8Aa-tdxLpxuPKtd7iGXptQ-Vhf49VqjpcxQtN7XeEuDPJQYvN_5psRtW8hDjM6wJftoPehOUYHpa4inOz2DL3cL58Xj8n66WG1uF0nQHPRJ5BJkRMjLWO5I9LRwnKZSyqytGScWwPgZJqmRpZEayqMENywkhPDU5fTks3Q-ejbduFjA7FXtY8Wqko3EDZR5YJxmgo2CM92wo2pwam287XuvtUukoG_GXkYvv300KloPTQWnO_A9soFryhR2wrUNl-1zVcJqX4rUJL9AA3HdtA</recordid><startdate>196903</startdate><enddate>196903</enddate><creator>Entenman, Cecil</creator><creator>Holloway, Roy J.</creator><creator>Albright, M.L.</creator><creator>Leong, George F.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>196903</creationdate><title>Bile acids and lipid metabolism: II. Essential role of bile acids in bile phospholipid excretion</title><author>Entenman, Cecil ; Holloway, Roy J. ; Albright, M.L. ; Leong, George F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e176t-e49670b9c337d09d18c59791642f355cbeed9222b9f0aa16b665b3f50b52d71f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1969</creationdate><topic>Animals</topic><topic>Bile - metabolism</topic><topic>Bile Acids and Salts - physiology</topic><topic>In Vitro Techniques</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Perfusion</topic><topic>Phospholipids - blood</topic><topic>Phospholipids - metabolism</topic><topic>Phosphorus Isotopes</topic><topic>Rats</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Entenman, Cecil</creatorcontrib><creatorcontrib>Holloway, Roy J.</creatorcontrib><creatorcontrib>Albright, M.L.</creatorcontrib><creatorcontrib>Leong, George F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of biochemistry and biophysics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Entenman, Cecil</au><au>Holloway, Roy J.</au><au>Albright, M.L.</au><au>Leong, George F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bile acids and lipid metabolism: II. Essential role of bile acids in bile phospholipid excretion</atitle><jtitle>Archives of biochemistry and biophysics</jtitle><addtitle>Arch Biochem Biophys</addtitle><date>1969-03</date><risdate>1969</risdate><volume>130</volume><issue>1</issue><spage>253</spage><epage>256</epage><pages>253-256</pages><issn>0003-9861</issn><eissn>1096-0384</eissn><abstract>The isolated rat liver perfusion system has been used to study the release of bile phospholipid P
32 following the injection of inorganic P
32 into the perfusate. It was demonsrtated that in the absence of added bile salt very little PLP
32 was excreted into bile, but when bile salt was added to the perfusate the PLP
32 excretion increased markedly. At the start of bile salt infusion, the specific activity of the bile phospholipids was lower than that of the liver, but at later times the specific activity of bile phospholipids was greater than liver PL specific activity. It is suggested that bile acids play an essential role in the transport of phospholipid from liver to bile.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>5778640</pmid><doi>10.1016/0003-9861(69)90031-9</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-9861 |
| ispartof | Archives of biochemistry and biophysics, 1969-03, Vol.130 (1), p.253-256 |
| issn | 0003-9861 1096-0384 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76351263 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Bile - metabolism Bile Acids and Salts - physiology In Vitro Techniques Liver - metabolism Male Perfusion Phospholipids - blood Phospholipids - metabolism Phosphorus Isotopes Rats Time Factors |
| title | Bile acids and lipid metabolism: II. Essential role of bile acids in bile phospholipid excretion |
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